Novel Approaches of Oxidative Stress Mechanisms in the Multiple Sclerosis Pathophysiology and Therapy

Adamczyk, Bożena; Niedziela, Natalia; Adamczyk-Sowa, Monika

doi:10.15586/codon.multiplesclerosis.2017.ch10

Cited by 7 publications

(6 citation statements)

References 106 publications

(127 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As mentioned above, mitochondrial dysfunction is one of the key factors in neurodegenerative process underlying MS progression. It contributes to increase oxidative stress levels, i.e., by overproduction of ROS, which further promotes formation of oxidized lipids [ 147 ]. Several studies suggest that oxidative stress is associated with increased levels of oxysterols produced by auto-oxidation (7-KC, 7β-OHC) as well as by enzymatic reaction, 24(S)-OHC [ 48 ]; all of which are indicators of neurodegeneration in MS [ 50 ].…”

Section: Ms Progressionmentioning

confidence: 99%

“…The 4-HNE, present in elevated concentrations in foamy macrophages and astrocytes in active demyelinating MS lesions [ 150 ], along with ROS, were found to be detrimental to CNS cell viability, as well as BBB integrity and functionality [ 152 ]. Several studies have indicated that increased levels of ROS and lipid peroxidation products in the CSF and plasma of MS patients, along with mitochondrial damage, strongly reiterates the importance of oxidative damage in MS progression [ 112 , 147 , 150 , 153 , 154 ].…”

Section: Ms Progressionmentioning

confidence: 99%

See 1 more Smart Citation

New Insights into Multiple Sclerosis Mechanisms: Lipids on the Track to Control Inflammation and Neurodegeneration

Podbielska

O’Keeffe

Pokryszko−Dragan

2021

IJMS

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a central nervous system disease with complex pathogenesis, including two main processes: immune-mediated inflammatory demyelination and progressive degeneration with axonal loss. Despite recent progress in our understanding and management of MS, availability of sensitive and specific biomarkers for these both processes, as well as neuroprotective therapeutic options targeted at progressive phase of disease, are still being sought. Given their abundance in the myelin sheath, lipids are believed to play a central role in underlying immunopathogenesis in MS and seem to be a promising subject of investigation in this field. On the basis of our previous research and a review of the literature, we discuss the current understanding of lipid-related mechanisms involved in active relapse, remission, and progression of MS. These insights highlight potential usefulness of lipid markers in prediction or monitoring the course of MS, particularly in its progressive stage, still insufficiently addressed. Furthermore, they raise hope for new, effective, and stage-specific treatment options, involving lipids as targets or carriers of therapeutic agents.

show abstract

Section: Ms Progressionmentioning

confidence: 99%

Section: Ms Progressionmentioning

confidence: 99%

New Insights into Multiple Sclerosis Mechanisms: Lipids on the Track to Control Inflammation and Neurodegeneration

Podbielska

O’Keeffe

Pokryszko−Dragan

2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Supplementary Figure S1: pilot experiments for the best study design. Different concentrations or different kinds of administration, i.e., (1) EAE+TEA: only the olive leaf tea ad libitum (oleuropein 1.5 mg/mL) (light blue line); (2) EAE +EXTRACT×3+TEA: olive leaf extract i.p. (45.96 mg/kg 3 times every second day) together with olive leaf tea ad libitum (yellow line); (3) EAE+EXTRACT×10: olive leaf extract i.p.…”

Section: Data Availabilitymentioning

confidence: 99%

“…A broad range of evidence suggests that oxidative stress plays a major role in the pathogenesis of neurodegenerative diseases, including multiple sclerosis (MS) [1,2]. Reactive oxygen species (ROS), which if produced in excess during inflammation lead to oxidative stress, have been implicated as mediators of demyelination and axonal damage in both MS and its animal models.…”

Section: Introductionmentioning

confidence: 99%

Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity

Giacometti

Grubić-Kezele

2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Numerous evidences suggest that plant polyphenols may have therapeutic benefits in regulating oxidative stress and providing neuroprotection in many neurodegenerative diseases, including multiple sclerosis (MS). However, these mechanisms are not yet completely understood. In this study, we investigated the effect of olive leaf polyphenols on oxidative stress through oxidation marker level and activity (TBARS, SOD, and GPX) and their protein expression (SOD1, SOD2, and GPX1), as well as the protein expression of Sirtuin 1 (SIRT1) and microglia markers (Iba-1, CD206, and iNOS) and myelin integrity (proteolipid protein expression) in the brain of rats with induced experimental autoimmune encephalomyelitis (EAE) and subjected to olive leaf therapy. Experiments were performed in male EAE DA rats, which were randomly divided into 2 main groups: EAE groups treated with the therapy of olive leaf (EAE+TOL) and untreated EAE control groups. The EAE treated groups consumed olive leaf tea instead of drinking water (ad libitum) from the beginning to the end of the experiment. In addition, olive leaf extract was injected intraperitoneally (i.p.) for the 10 continuous days and started on the 8th day after EAE induction. The clinical course was monitored in both groups until the 30th day after EAE induction. Our results demonstrated that TOL attenuated the clinical course of EAE; reduced the oxidative stress (by decreasing the concentration of MDA); upregulated antioxidant enzymes (SOD1, SOD2, and GPX1), SIRT1 (overall and microglial), and anti-inflammatory M2 microglia; downregulated proinflammatory M1 type; and preserved myelin integrity. These data support the idea that TOL may be an effective therapeutic approach for treating MS and other neurodegenerative diseases.

show abstract

“…Numerous studies reported that oxidative stress (OS) play a mayor role in pathophysiology of various diseases, including ADs (WEST, 2000;CILENŠEK et al, 2012;ADAMCZYK et al, 2017). OS is the result of an imbalance between the amount of reactive oxygen species (ROS) and the capacity of antioxidant defence systems (ALLEN and TRESINI, 2000).…”

Section: Introductionmentioning

confidence: 99%

Association of GSTT1 and GSTM1 gene polymorphisms with susceptibility to autoimmune diseases: A preliminary study

Grujičić¹,

Radović-Jakovljević²,

Mihaljevic³

et al. 2018

Kragujevac J Science

View full text Add to dashboard Cite

Autoimmune diseases (ADs) are chronic conditions initiated by the loss of immunological tolerance to self-antigens. The aim of this study was to detrmine how polymorphisms of glutathione S-transferases T1 and M1 (GSTT1 and GSTM1) genes influences on the occurrence of two autoimmune diseases: multiple sclerosis (MS) and Hashimoto's thyroditis (HT). A multiplex polymerase chain reaction (PCR) was used to detect the deletions in GSTT1 and GSTM1 genes. Our results showed that patients with ADs had significantly higher (p < 0.05) frequency of GSTM1 null genotype compared to controls (44.4% vs. 0.0%, respectively). However, the homozygous deletion of both analyzed genes (GSTT1 null/GSTM1 null) showed no significant differences between these genotypes in the patients and controls (11.1% vs 0.0%, respectively). Our results showed that observed differences in the distribution of GSTT1 and GSTM1 null genotype in patients depending on the diagnosis (MS or HT) when compared to the same frequency of genotypes in control, were not statistically significant (p > 0.05). This study suggests the potential role of GSTM1 deletion on ADs susceptibility, but on the other hand this study should be repeated in other patients with the same or similar diagnosis of ADs.

show abstract

Novel Approaches of Oxidative Stress Mechanisms in the Multiple Sclerosis Pathophysiology and Therapy

Cited by 7 publications

References 106 publications

New Insights into Multiple Sclerosis Mechanisms: Lipids on the Track to Control Inflammation and Neurodegeneration

New Insights into Multiple Sclerosis Mechanisms: Lipids on the Track to Control Inflammation and Neurodegeneration

Olive Leaf Polyphenols Attenuate the Clinical Course of Experimental Autoimmune Encephalomyelitis and Provide Neuroprotection by Reducing Oxidative Stress, Regulating Microglia and SIRT1, and Preserving Myelin Integrity

Association of GSTT1 and GSTM1 gene polymorphisms with susceptibility to autoimmune diseases: A preliminary study

Contact Info

Product

Resources

About