Melatonin reduced endometrial hyperplasia induced by estradiol in female albino rats

Abdel-Hamid, Heba A.; Zenhom, Nagwa M.; Toni, Nisreen D. M.

doi:10.4149/gpb_2018035

Cited by 9 publications

(4 citation statements)

References 33 publications

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“…Consistent with the current study, previous reports [ 29 , 49 ] demonstrated similar findings in connection with the ability of EB to decrease cleaved caspase 3, an apoptosis marker, in EB-induced EH in rats. On the other hand, the EH+IRB-treated rats showed higher uterine cleaved caspase 3 compared to EH untreated rats.…”

Section: Discussionsupporting

confidence: 93%

Protective Effects of Irbesartan, an Angiotensin Receptor Blocker with PPARγ Agonistic Activity, against Estradiol Benzoate-Induced Endometrial Hyperplasia and Atypia in Female Rats via Modulation of TNFα/Survivin Pathway

et al. 2021

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Endometrial hyperplasia (EH) is a common gynecological problem and may progress to carcinoma. Early detection and management of EH are mandatory for the prevention of endometrial cancer. Activation of the renin–angiotensin system and angiotensin II signaling are involved in the progression of precancerous and cancerous lesions. However, no studies have evaluated the role of this system in estradiol benzoate (EB)-induced EH and atypia. Irbesartan (IRB), an angiotensin II receptor blocker with peroxisome proliferator-activated receptor gamma (PPARγ) agonistic activity was administered (30 mg/kg/d) in EB-treated (60 µg/100 g bodyweight, intramuscularly, three times per week) or untreated rats for 4 weeks. Uterine weight changes, malondialdehyde, superoxide dismutase (SOD), tumor necrosis factor-alpha (TNFα), survivin, cleaved caspase 3, interleukin-10 (IL10), and PPARγ were measured in addition to undergoing histopathological examination. Results showed that EB-induced EH and atypia significantly increased the uterine body weight, malondialdehyde, TNFα, and survivin, accompanied with significantly decreased SOD, cleaved caspase 3, IL10, and PPARγ, with typical histopathological changes of EH and atypia. Coadministration of IRB significantly prevented EB-induced biochemical and histopathological changes. The protective effects of IRB may be attributed to its anti-inflammatory and antioxidant properties, reduction of survivin, and increased levels of cleaved caspase 3.

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Section: Discussionsupporting

confidence: 93%

Protective Effects of Irbesartan, an Angiotensin Receptor Blocker with PPARγ Agonistic Activity, against Estradiol Benzoate-Induced Endometrial Hyperplasia and Atypia in Female Rats via Modulation of TNFα/Survivin Pathway

et al. 2021

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“…However, this relationship was not observed in the healthy and pregnant groups. On the other hand, it was also stated that there may be a relationship between endometrial hyperplasia and oxidative stress in women (Gomez‐Zubeldia et al., 2008; Pejic et al, 2015) and rats (Abdel‐Hamid et al., 2019). However, according to our best literature knowledge, no study has been conducted investigating the relationship between oxidative stress and asymptomatic CEH in dogs.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the usability of kisspeptin and oxidative stress parameters in the early diagnosis of asymptomatic cystic endometrial hyperplasia in dogs

Kurt

Eşki

Mıs

2021

Reprod Domestic Animals

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This study aimed to investigate the differences in oxidative stress index (OSI) and kisspeptin levels in clinically asymptomatic dogs with cystic endometrial hyperplasia (CEH) compared to healthy and pregnant dogs, and to determine the usability of the obtained results in the diagnosis of asymptomatic CEH. The study comprised three groups; a healthy (n = 8), a pregnant (n = 10) and a CEH (n = 10). All dogs in the three groups were included in the study at the 30 ± 3th day after estrus, and blood samples were collected for analysis of kisspeptin, total antioxidant status (TAS), total oxidant status (TOS), progesterone (P4), estradiol (E2) and some biochemical parameters (TSH; thyroid stimulating hormone, ALT; alanine aminotransferase, AST; aspartate aminotransferase, ALP; alkaline phosphatase, LDH; lactate dehydrogenase, CRE; creatine and BUN; blood urea nitrogen). In addition, OSI value was calculated. P4 and ALT and BUN levels were significantly lower and higher in CEH group than the pregnant group, respectively (p < .05). While kisspeptin and TAS levels were significantly lower in CEH group compared to the healthy and pregnant groups (p < .01), OSI level increased dramatically. In conclusion, it was confirmed that CEH clearly affected kisspeptin and OSI levels, and it is thought that these parameters may be an alternative diagnostic tool for the detection of CEH after further studies.

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“…Drugs including toremifene, genistin, daidzin, glycyrrhizae radix, glycyrrhizin, Juzen-taiho-to and Shimotsu-to inhibited the estrogen-related EC carcinogenesis by downregulating IL-1α ( 32 – 36 ). And the adverse histopathological changes in endometrium induced by estradiol benzoate can be reduced or prevented by diacerein via downregulating IL-1β ( 97 ), irbesartan via upregulating IL-10 ( 98 ) and melatonin via upregulating IL-2 ( 99 ).…”

Section: Roles Of Interleukins In Ecmentioning

confidence: 99%

The roles and clinical applications of interleukins in endometrial carcinoma

Zang

Liu

et al. 2022

Front. Oncol.

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As a common malignant tumor of the female reproductive system, endometrial carcinoma (EC) seriously endangers women’s health with an increasing incidence. The oncogenesis and progression of cancer are closely linked with immune microenvironment, of which interleukins are the important components. In order to illustrate the roles and clinical applications of interleukins in EC, literature of interleukins and EC were reviewed. Based on the present studies, interleukins play crucial roles in the oncogenesis and development of EC via regulating the proliferation, migration, invasion, angiogenesis, apoptosis, pyroptosis and autophagy of EC as well as the immune function against EC. And some of the interleukins seems to have prospective clinical applications in EC, such as evaluating the risk of tumorigenesis, discriminating the malignancy from benign disorders or normal condition, indicating cancer aggressiveness, predicting the prognosis of patients and serving as the novel therapy. However, there is still a long way to go before the clinical applications of interleukins in EC come into reality. Nevertheless, it is certain that the exploration of interleukins will definitely be of great benefit to the screening, diagnosis and treatment of EC in the future.

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Melatonin reduced endometrial hyperplasia induced by estradiol in female albino rats

Cited by 9 publications

References 33 publications

Protective Effects of Irbesartan, an Angiotensin Receptor Blocker with PPARγ Agonistic Activity, against Estradiol Benzoate-Induced Endometrial Hyperplasia and Atypia in Female Rats via Modulation of TNFα/Survivin Pathway

Protective Effects of Irbesartan, an Angiotensin Receptor Blocker with PPARγ Agonistic Activity, against Estradiol Benzoate-Induced Endometrial Hyperplasia and Atypia in Female Rats via Modulation of TNFα/Survivin Pathway

Investigation of the usability of kisspeptin and oxidative stress parameters in the early diagnosis of asymptomatic cystic endometrial hyperplasia in dogs

The roles and clinical applications of interleukins in endometrial carcinoma

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