Melatonin improves humoral and cell-mediated immune responses of male golden hamster following stress induced by dexamethasone

Melatonin prevents dexamethasone-induced testicular oxidative stress and germ cell apoptosis in golden hamster,Mesocricetus auratus

“…Immunosuppressive and anti‐inflammatory properties of acute and pharmacological doses of glucocorticoid have long been recognised (Guilpain & Le, ). Previous studies from our laboratory highlight the immunoenhancing activity of melatonin on Dex‐induced immune suppression (Gupta & Haldar, ; Vishwas et al ., ), but the ability of melatonin to prevent oxidative stress to testis induced by Dex has never been reported. The present study establishes the involvement of Dex in testicular oxidative stress that induced germ cell apoptosis and also the ameliorative potentials of melatonin through its antioxidative (Rodriguez et al ., ; Galano et al ., ) and anti‐apoptotic (Ji et al ., ) attributes.…”

Melatonin membrane receptor (MT1R) expression and nitro-oxidative stress in testis of golden hamster, Mesocricetus auratus: An age-dependent study

“…Therefore, it can be proposed that increased circulatory level of corticosterone and GR expression in testes of aged hamster suggest an altered stress response and might have contributed to the enhanced oxidative stress in testes. Previous reports suggest an inverse relationship between plasma level of corticosterone and melatonin (Gupta and Haldar, 2013;Vishwas et al, 2013b). Earlier reports suggest that diminished intra-testicular testosterone following treatment with ethane dimethane sulphonate (EDS) inhibit expression of testicular antioxidant enzymes including SOD, CAT, and GSH-Px (Zini and Schlegel, 2003).…”

Photoperiodic regulation of melatonin membrane receptor (MT1R) expression and steroidogenesis in testis of adult golden hamster, Mesocricetus auratus

“…The golden hamster, M. auratus is a long-day seasonal breeder with its neuroendocrine axis being highly sensitive to the changing photoperiod [25]. It is an excellent animal model for the study of photoperiodic modulation of reproduction [27] and immunity [28]. Testis is the prime source of circulatory level of testosterone and the unique site for spermatogenesis in mammals.…”