Melatonin membrane receptor (MT1R) expression and nitro-oxidative stress in testis of golden hamster, Mesocricetus auratus: An age-dependent study

Mukherjee, Arun; Haldar, Chandana

doi:10.1016/j.exger.2015.06.022

Cited by 22 publications

(11 citation statements)

References 67 publications

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“…Although certain mechanisms of aging have been proposed, theories linking aging and cellular oxidative stress have received more support (29,30). With the improvement of living standards all over the world, individuals are increasingly concerned about their appearance and health (3).…”

Section: Discussionmentioning

confidence: 99%

Effects of rhein lysinate on D-galactose-induced aging mice

Zhen

Lin

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the anti-aging effects of rhein lysinate (RHL), and to explore its mechanism of action in a D-galactose-induced aging mouse model. Aging was induced by D-galactose (100 mg/kg/day) that was subcutaneously injected to animals for 8 weeks. RHL was simultaneously administered once a day by intragastric gavage. The appetite, mental condition, body weight and organ index of the mice were monitored. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were determined, and the levels of malondialdehyde (MDA) in the liver, kidney and serum were measured by appropriate assay kits. Western blot analysis was used to detect proteins associated with age. The results indicated that RHL may improve the appetite, mental state and organ conditions of the model mice, improve the activities of SOD and GSH-Px, reduce MDA levels and modulate the expression of age-associated proteins (Sirtuin 1, p21 and p16) in D-galactose-induced mice. Therefore, RHL may be effective at suppressing the aging process through a combination of enhancing antioxidant activity, scavenging free radicals and modulating aging-associated gene expression.

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Section: Discussionmentioning

confidence: 99%

Effects of rhein lysinate on D-galactose-induced aging mice

Zhen

Lin

et al. 2015

Experimental and Therapeutic Medicine

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“…Interestingly, melatonin group showed normal spermatogenesis and preserved normal germ cell counts as well as nuclear and cytoplasmic features of the testicular cells. These results may be attributed to that melatonin is expressed in the testicular cells [ 79 ] and induce the spermatogonial differentiation to functional haploid germ cells [ 37 ]. Melatonin also increases the activity of plasminogen in ram sperms [ 80 ].…”

Section: Discussionmentioning

confidence: 99%

Lack of retinoid acid receptor-related orphan receptor alpha accelerates and melatonin supplementation prevents testicular aging

Sayed

Mokhtar

Fernández-Ortiz

et al. 2020

Aging

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The role of retinoid acid receptor-related orphan receptor alpha (RORα) on male reproductive functions during aging is unclear. Here, we analyze the morphological changes in the testis of both young and aged RORα-deficient mice, with and without melatonin supplementation. Young mutants showed vacuolation, degeneration and pyknosis of spermatogenic epithelium and Sertoli cells. Aged mutants showed atrophy of the seminiferous tubules and absence of mitotic spermatogenic cells. Absence of sperms in many tubules, loss of acrosomal cap, vacuolation and hypertrophy of Sertoli cells were detected in aged mice, with a significant reduction in the number of seminiferous tubules and a significant increase in the number of Leydig cells and telocytes. Repair in seminiferous tubules and interstitial tissues with enhancement of spermatogenesis was observed in melatonin-treated aged mice. Young mutants overexpressed VEGF that was weaker in aged animals and observed only in the spermatocytes, while melatonin increased VEGF expression in spermatocytes and spermatids. Caspase 3 increased in both young and aged mutant mice in all seminiferous tubules and interstitium; caspase 3 immunostaining in seminiferous tubules, however, showed a normal pattern of apoptosis with melatonin supplementation. The present study reports that age-dependent testicular changes in RORα mutant mice were recovered by melatonin treatment.

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“…All the other reagents used in this study were of analytical research grade. The doses of ampicillin sodium, melatonin and Vit-C were chosen based on the earlier studies [14][15][16][17].…”

Section: Drugsmentioning

confidence: 99%

Nephroprotective effect of melatonin and L-Ascorbic acid (Vitamin-C) against ampicillin- induced toxicity in Funambulus pennanti

Rastogi

Gupta

Haldar

et al. 2020

Egyptian Journal of Basic and Applied Sciences

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Ampicillin is one of the most commonly prescribed antibiotics against intrarenal infections. Prolonged use of ampicillin has been found to be associated with a high rate of free-radical generation and oxidative stress induced nephrotoxicity. In the present study, we report the comparative effects of melatonin and vitamin-C (Vit-C) in ameliorating the biochemical and structural alterations in renal tissues caused by ampicillin sodium. Biochemical parameters such as acid phosphatase (ACP), alkaline phosphatase (ALP), creatinine and urea levels in urine and serum as well as oxidative stress parameters such as superoxide dismutase (SOD) activity, catalase activity, total antioxidant status (TAS%) and lipid peroxidation in the renal cortical tissues were accessed upon treatment of melatonin and Vit-C following ampicillin sodium administration in Funambulus pennanti. Ampicillin treatment increased ACP, ALP, creatinine and urea levels in serum and urine, indicating renal damage. It also induced oxidative stress by increasing lipid peroxidation and decreasing the activity of antioxidative enzymes. However, the exogenous melatonin or Vit-C treatment inhibited ampicillin mediated renal damages. Melatonin or Vit-C pre-treatment significantly decreased ACP, ALP, creatinine, urea, TBARS level and increased SOD, catalase activity and TAS%. Our results suggest that the antibiotic induced nephrotoxicity can be ameliorated by melatonin or Vit-C via reduction of oxidative stress in renal tissues.

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Melatonin membrane receptor (MT1R) expression and nitro-oxidative stress in testis of golden hamster, Mesocricetus auratus: An age-dependent study

Cited by 22 publications

References 67 publications

Effects of rhein lysinate on D-galactose-induced aging mice

Effects of rhein lysinate on D-galactose-induced aging mice

Lack of retinoid acid receptor-related orphan receptor alpha accelerates and melatonin supplementation prevents testicular aging

Nephroprotective effect of melatonin and L-Ascorbic acid (Vitamin-C) against ampicillin- induced toxicity in Funambulus pennanti

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