Melanotic neuroectodermal tumour of infancy: A report of two cases

Moussa, Shady Ahmed; Elsayed, MohamedA; Mansour, Soad; Mobarak, Fahmy A.

doi:10.1016/j.ijscr.2018.11.004

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…More than 500 cases of MNTI have been reported worldwide by Rachidi et al In addition to the 472 cases reported between 1918 and 2013 as a part of the largest retrospective study, [5] we found 49 cases reported between January 2014 and June 2021 by searching PubMed [3,4,9–32,36–38] . In a systematic review of 472 MNTI cases, [5] most cases developed within 1 year of age, with more than 90% of cases occurring in the craniofacial region, such as the maxilla (60.3%), skull (18.1%), and mandible (10.3%).…”

Section: Discussionmentioning

confidence: 75%

Melanotic neuroectodermal tumor of infancy in the mandible

et al. 2021

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Rationale: Melanocytic neuroectodermal tumor of infancy (MNTI) is a rare benign pigmented neoplasm that arises from the neural crest and has an aggressive growth pattern. It is predominantly seen in infants under 1 year of age, and the most common site of involvement is the maxilla. The currently accepted treatment is removal by surgical resection. Herein, we report a case of MNTI that involved the anterior alveolar ridge of the mandible in a 6-month-old infant. Patient concerns: A case of a 6-month-old male child with a huge mass in the anterior alveolar ridge of the mandible. Diagnosis: The tumor was diagnosed using histopathological and immunohistochemical techniques on the biopsy specimen obtained following incisional biopsy. Based on the findings, a final diagnosis of MNTI was established. Interventions: Radical resection of the tumor was performed, after determining the extent of resection by referring to the mandibular 3D model created using the pre-operative CT data. Outcomes: The postoperative course was uneventful, and no recurrence has been observed to date for more than 4 years after surgery. Lessons: This case emphasizes that early diagnosis and radical surgery are critical to the effective treatment, as MNTI exhibits rapid and destructive growth. It also requires careful and close follow-up because of high recurrence rates.

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Section: Discussionmentioning

confidence: 75%

Melanotic neuroectodermal tumor of infancy in the mandible

et al. 2021

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“…Radiographic examination is useful in determining the surgical design. 10,16,17 Histologically, the H&E stained specimen showed a biphasic population of cells forming nests, tubules, or alveolar structures within a fibro cellular connective stroma. The alveolar and tubular structures are lined by a cuboidal epithelioid cell with granules of melanin pigment.…”

Section: Discussionmentioning

confidence: 99%

Pigmented Neuroectodermal Tumor in Maxilla of an Infant : Report of a Rare Neoplasm in Bandung, Indonesia

Khamila

Oli'i

Hardianto

et al. 2022

IJMBS

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Introduction: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, locally invasive, fast-growing neoplasm with a high recurrence rate, which usually affecting children under 1 year of age. The tumor originated from the neural crest, most commonly found in the head and neck region, especially in the maxilla. Current standard for treatment is by surgical excision, but the high recurrency rate (10% - 60%) and the possiblity of malignant transformation makes the extent of excision debatable. Case report: An 8 -months-old boy was referred to our department with a rapidly growing mass in the anterior of the maxilla since two months prior. The mass was bluish in color, firm, and non-ulcerative. We treated the patient with excision under general anesthesia. Pathology examination was done and MNTI was confirmed. There is no recurrency at 2 years follow-up. Summary: Diagnosis and treatment of MNTI must be done meticulously due to the aggressive nature of the tumor. Wide surgical excision is the best treatment for this case, and routine follow-up must be done to detect any reccurency. Keywords: melanotic neuroectodermal tumor; infancy; maxilla, surgical excision

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“…(2) DISCUSSION OF MANAGEMENT Management of newly born haemangioma involved a wide range of treatment options starting from observation for spontaneous regression of the lesion and conservative propranolol treatment to surgical intervention with either conventional resection or with adjunctive laser therapy. (7,10) Immediately, the decision was taken to remove the lesion entirely under local anaesthesia, after performing full clinical examination, ultrasound, fine needle aspiration biopsy, (Fig. 2) and obtaining the consent of the patient's parents.…”

Section: Differential Diagnosismentioning

confidence: 99%

Large Intraoral Maxillary Haemangioma in a Newly Born Infant

Elsayed¹,

Atwa²,

Altaweel³

et al. 2019

Journal of Evolution of Medical and Dental Sciences

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Intraoral Haemangioma in newly born infants is rare worldwide. Here we report a new case of a large haemangioma mass extruding outside the oral cavity, present at the time of natural child birth, in January 2016, at Al-Zahraa University Hospital in Egypt. A new born female infant had a large lesion bulging from the oral cavity. It was soft sessile, filling the whole mouth of the baby and disturbing normal sucking and feeding process. The obstetrician immediately requested a consultation with an oral and maxillofacial surgeon. History of the mother's pregnancy was normal without any abnormal symptoms. Even the routine ultrasound examination during pregnancy didn't indicate the presence of this lesion. In the present description, we report the first case of this condition which is not seen in our institute before. On clinical examination of this case, the lesion was 3.2 cm in diameter and was soft with non-ulcerated thin covering mucosa. It was mobile not fixed and 'no any other abnormalities were detected on the physical examination of the patient (Fig. 1). Upper lip soft tissue examination by superficial probe revealed a well-circumscribed, bear shaped, thin-walled, solid, and soft tissue lesion with homogenous iso-to hypo-echoic echotexture. It is measuring about 33 x 13 mm in AP & craniocaudal diameters. It showed minimal colour filing on Doppler examination. It shows no sonographic evidence of calcification, septation or cystic changes inside. No evidence of deep tissue invasion.

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Melanotic neuroectodermal tumour of infancy: A report of two cases

Cited by 4 publications

References 13 publications

Melanotic neuroectodermal tumor of infancy in the mandible

Melanotic neuroectodermal tumor of infancy in the mandible

Pigmented Neuroectodermal Tumor in Maxilla of an Infant : Report of a Rare Neoplasm in Bandung, Indonesia

Large Intraoral Maxillary Haemangioma in a Newly Born Infant

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