Melanotic Neuroectodermal Tumor of Infancy

Goswami, Mridula; Bhushan, Urvashi; Mohanty, Sujata

doi:10.7860/jcdr/2016/18206.8009

Cited by 3 publications

(5 citation statements)

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“…5,6,12 MNTIs of the head and neck are uncommon aggressive lesions and mainly affect the jaw bones. [17][18][19] Further, our literature review demonstrated that 92.5% of tumors affected the maxilla and 7.5% affected the mandible. In previous studies, researchers observed that MNTI of the jaw bones is found mainly in children below 1 year of age.…”

Section: Discussionmentioning

confidence: 75%

“…We also observed that lesions was seen as a rapidly growing asymptomatic bluish swelling, which corroborates the information previously published in the literature. [17][18][19] Further, our literature review demonstrated that 92.5% of tumors affected the maxilla and 7.5% affected the mandible. 13,18 Histologically, the tumor consists of a biphasic population of small neuroblast-like cells and larger melaninproducing epithelioid cells arranged in an alveolar architecture, with cords and trabeculae intersected by dense fibroblastic stroma.…”

Section: Discussionmentioning

confidence: 75%

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Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

et al. 2018

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The aim of the present study was to integrate the available data published on melanotic neuroectodermal tumor of infancy (MNTI) of the jaw bones. An electronic search was undertaken in April 2018. Hundred forty‐seven publications and 371 patients were included. The lesion was more prevalent in males and in the second to sixth months of life. The lesions mostly presented as a rapidly growing bluish swelling and the most commonly involved was the anterior maxilla. The mean follow‐up was 51.1 months (range 1‐408 months). Age (P ≤ .0001), location (P = .007), occurrence of lymph node metastasis (P ≤ .0001), treatment (P = .001), recurrence (P ≤ .0001), and distant metastasis (P = .0001) were independently associated with survival. Recurrence was significantly correlated with age (P = .0001), distant metastasis (P = .0001), and treatment (P = .0001). Patients older than 12 months, with lesions in the mandible, positive regional lymph node metastasis, treated with chemotherapy, recurrence, or distant metastasis presented the worst prognosis.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 75%

Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

et al. 2018

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“…[1][2][3][4][5][6] Macroscópicamente se observa como un tumor pigmentado que en algunos casos se podría confundir con una malformación vascular, microscópicamente se evidencia un estroma fibroso denso que contiene una población pequeña de células de neuroblastoma con núcleos hipercromáticos y citoplasma escaso; se encuentran células cúbicas de gran tamaño con contenido de melanina; lo cual coincidió con el informe emitido por el departamento de patología. [5][6][7] En las radiografías convencionales se observa lesiones óseas radiolúcidas con o sin márgenes delimitados; si el tumor es grande se aprecia destrucción ósea y desplazamiento de estructuras adyacentes. La TC evidencia una lesión hiperdensa bien delimitada, aunque hay variantes que se describen como lesiones hipodensas.…”

Section: Discussionunclassified

“…7-10 Algunos pacientes tienen niveles altos AVM en orina y se asocia con tumores agresivos, sin embargo la sola presencia de este metabolito no es diagnóstica. [5][6][7][8][9][10][11] La inmunohistoquímica evidencia positividad para enolasa neural específica, citoqueratina, HMB45 (human melanoma black 45), sinaptofisina, antígeno de membrana epitelial, proteína glial fibrilar acida y vimentina, pero es negativa a la proteína S-100. La expresión de Ki-67/CD99 es poco común en el TNMI, y podría asociarse con un crecimiento agresivo.…”

Section: Discussionunclassified

“…La expresión de Ki-67/CD99 es poco común en el TNMI, y podría asociarse con un crecimiento agresivo. [5][6][7][8][9][10][11][12] El diagnóstico diferencial del TNMI incluye: quistes (nasopalatino, glóbulo-maxilar); lesiones odontogénicas (odontomas, mixoma odontogénico); lesiones no odontogénicas no neoplásicas (granuloma central de células gigantes, malformación arteriovenosa, cefalohematoma); y lesiones neoplásicas no odontogénicas (rabdomiosarcoma, linfoma de Burkitt, sarcoma de Edwing, neuroblastoma), teniendo en cuenta que en los cuatro últimos no hay población celular polifenotípica con expresión neural, epitelial, ni con los marcadores melanocíticos característicos del TMNI, pudiendo descartarse teniendo en cuenta el cuadro clínico y las características radiológicas. 5,[12][13][14] La cirugía es el tratamiento de elección que ofrece una alta probabilidad de curación a largo plazo, 15 y fue el tratamiento realizado con éxito en el paciente de este reporte.…”

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Tumor neuroectodérmico melanótico de la infancia. Presentación de un caso clínico

2019

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ResumenEl tumor neuroectodérmico melanótico de la infancia es una rara condición que tiene su origen en la cresta neural, se han documentado alrededor de 486 casos desde que se lo describió por primera vez desde 1918, frecuentemente ubicado en el maxilar superior (60-80%) y que se caracteriza por un rápido crecimiento. Se describe un caso femenino de un lactante menor de 5 meses de edad, que presentó tumefacción en región parietooccipital, de dos meses de evolución. La radiografía de cráneo mostró una imagen de neoformación ósea de bordes lobulados a nivel parietooccipital. La tomografía computarizada de cráneo evidenció una lesión hiperostósica parierto-occipital medial con áreas de osteólisis, sin realce con el medio de contraste; la resonancia magnética nuclear de cráneo reveló una tumoración isointensa en T1 y T2 supratentorial que desplaza el parénquima cerebral y el seno sagital. Se realizó una resección quirúrgica evidenciándose un tumor óseo, que infiltraba la duramadre, grisáceo, semiduro con trabéculas óseas, poco vascularizadas. El estudio anatomopatológico describió un tumor neuroectodérmico melanótico de la infancia.PALABRAS CLAVE: tumor neuroectodérmico melánotico, cresta neural, neoplasia.Abstract Melanotic neuroectodermal tumor of infancy is a rare condition that originates in the neural crest. About 486 cases have been documented since it was first described in 1918. It is frequently located in the upper jaw (60-80%) and it is characterized by rapid growth. This report is of a female case of an infant under 5 months, who presented two-month-evolution swelling in the parieto-occipital region. Skull radiograph showed an image of bone neoformation of lobulated edges at the parieto-occipital level. Tomography of the skull showed medial parierto-occipital hyperosotic injury with areas of osteolysis without contrast enhancement. Nuclear magnetic resonance of the skull revealed isointense tumor in T1 and supratentorial T2 that displaces the cerebral parenchyma and sagittal sinus. Surgical resection was performed, showing grayish, semi-hard bone tumor with undervascularized bone trabeculae that infiltrated the dura mater. Anatomopathological study described a melanotic neuroectodermal tumor of infancy.KEYWORDS: neuroectodermal tumor, melanotic, neural crest, neoplasm.Resumo O tumor neuroectodérmico melanótico da infância é uma rara condição que tem a origem na cresta neural. Há documentado cerca de 486 casos desde que foi descrito pela primeira vez desde 1918, frequentemente no maxilar superior (60-80%) e que se caracteriza por um rápido crescimento. Se descreve um caso de uma paciente lactante de sexo feminino menor de 5 meses de idade, que apresentou tumefação em região parietooccipital, de dois meses de evolução. O raio x de crâneo mostrou uma imagem de neoformação óssea de fronteiras lobuladas a nível parieto-ocipital. A tomografia de crâneo revelou uma lesão hiperostosica parietooccipital medial com áreas de osteolisis, sem realce com o meio de contraste; a ressonância magnética nuclear de crâneo re...

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Melanotic Neuroectodermal Tumor of Infancy: the Use of Immunohistochemical Analysis

Sousa¹,

Almeida²,

Mendes³

et al. 2022

Acta Stomatol Croat

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The Melanotic Neuroectodermal Tumor of Infancy (MNTI) is an asymptomatic, pigmented neoplasm characterized by a fast and locally aggressive growth along with a rare tissue formation. In the diagnostic process, the use of imaging exams can suggest a local destruction suggestive of malignancy, a sign of bone remodeling and expansion. Therefore, as any early diagnosis minimizes risks and improves the prognosis of treatment for the patient, the aim of this study was, based on a clinical case report, to corroborate the use of histopathological analysis associated with immunohistochemistry. Thus, we conclude that the immunohistochemical exam is of great importance for a better complementation of the MNTI diagnosis process. In addition, it can reveal signs of possible aggressive growth.

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Melanotic Neuroectodermal Tumor of Infancy

Cited by 3 publications

References 4 publications

Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

Tumor neuroectodérmico melanótico de la infancia. Presentación de un caso clínico

Melanotic Neuroectodermal Tumor of Infancy: the Use of Immunohistochemical Analysis

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