Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

Pontes, Flávia Sirotheau Corrêa; Souza, Lucas Lacerda de; Uchôa, Daniel Cavalléro Colares; Joaquim, Andrea Maia Correa; Nascimento, Liliane Silva do; Rezende, Diogo dos Santos da Mata; Pontes, Hélder Antônio Rebelo

doi:10.1002/hed.25514

Cited by 22 publications

(13 citation statements)

References 23 publications

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“…The diagnosis of MNTI can be performed mainly by radiological characteristics in association with histopathological examinations ( 4 , 5 ). However, immunohistochemical analyses and molecular studies are useful and can contribute to the diagnosis of this neoplasm, especially in difficult cases and particularly in small biopsies with the possibility of differentiating this pathological change from other tumors present in childhood ( 6 - 9 , 16 ).…”

Section: Discussionmentioning

confidence: 99%

Melanotic Neuroectodermal Tumor of Infancy: the Use of Immunohistochemical Analysis

Sousa¹,

Almeida²,

Mendes³

et al. 2022

Acta Stomatol Croat

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The Melanotic Neuroectodermal Tumor of Infancy (MNTI) is an asymptomatic, pigmented neoplasm characterized by a fast and locally aggressive growth along with a rare tissue formation. In the diagnostic process, the use of imaging exams can suggest a local destruction suggestive of malignancy, a sign of bone remodeling and expansion. Therefore, as any early diagnosis minimizes risks and improves the prognosis of treatment for the patient, the aim of this study was, based on a clinical case report, to corroborate the use of histopathological analysis associated with immunohistochemistry. Thus, we conclude that the immunohistochemical exam is of great importance for a better complementation of the MNTI diagnosis process. In addition, it can reveal signs of possible aggressive growth.

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Section: Discussionmentioning

confidence: 99%

Melanotic Neuroectodermal Tumor of Infancy: the Use of Immunohistochemical Analysis

Sousa¹,

Almeida²,

Mendes³

et al. 2022

Acta Stomatol Croat

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“…Due to the age of patients, prognosis and possible complications, radiotherapy is not recommended [1]. According to the literature, recurrence is observed in 20-25.6% of patients [11,12,13], and metastases to distant organs are observed in 3%-12.8% of patients treated [11,13]. In the described case, recurrence appeared relatively early -after 2 months, and was associated with the non-radical nature of the first surgery.…”

Section: Discussionmentioning

confidence: 99%

Melanotic neuroectodermal tumor of infancy. Case Report.

Haberko¹,

Lewandowski²,

Brodowski³

et al. 2021

J Pre Clin Clin Res.

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This case report presents the epidemiology, symptomathology, pathogenesis and treatment of a melanotic neuroectodermal tumour of infancy. MNTI is a rare tumour that is seen usually at or around birth. It is usually localised in facial region. The tumour originated from medial part of alveolar process of maxilla. Presented case developed in maxilla of four months old girl. Excision of a tumour with a dental germ 61 was performed. Despite MNTI shows benign hystological character it has a high recurrence potential. Two months after first operation during routine follow up control, there was a tumour in oral cavity that was suspected to be relapse. Patient undergone second prodecure in general anesthesia. Tumour was excised with radical margins. Due to complex funcitional and aesthetic character of facial region patients need specialistic treatment and rehabilitation of masticatory organ. Frequent presence of dental germs in the mass of tumour often causes malocclusion.

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“…This study followed the PRISMA Statement guidelines. 12 The methodology of this research has already been applied in other previous studies 13 and new criteria of analysis have been used in the current study to analyze malignant lesions.…”

Section: Methodsmentioning

confidence: 99%

Liposarcoma of oral cavity: Systematic review of cases reported to date and analysis of prognostic factors

et al. 2020

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The aim of this study was to integrate the available data published on Liposarcomas (LPSs) of the oral cavity into an analysis of its clinical features, treatment modalities, and prognostic factors. An electronic search was undertaken in January 2019. The eligibility criteria included publications that had enough clinical and histological information to confirm the diagnosis. Forty‐five publications (104 LPSs) were included. The lesion was more prevalent in males from the fifth to seventh decades of life. Treatment (P = .03) and distant metastasis (P = .0001) were independently associated with survival. A lower possibility of recurrence was statistically associated with age (younger patients) (P = .03), tumor size (smaller than 2.8 cm) (P = .001), and treatment (radical surgery) (P = .04). LPS presents a good survival for patients after 5 years of follow‐up (66.4%). Patients who were treated with conservative surgery and presented with distant metastasis showed poor prognosis.

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Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

Cited by 22 publications

References 23 publications

Melanotic Neuroectodermal Tumor of Infancy: the Use of Immunohistochemical Analysis

Melanotic Neuroectodermal Tumor of Infancy: the Use of Immunohistochemical Analysis

Melanotic neuroectodermal tumor of infancy. Case Report.

Liposarcoma of oral cavity: Systematic review of cases reported to date and analysis of prognostic factors

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