Melanoma and Other Melanocytic Skin Lesions

Weedon, David

doi:10.1007/978-3-642-69574-2_1

Cited by 6 publications

(1 citation statement)

References 325 publications

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“…LM and LMM have slow growth rates and are associated with less potential for metastatic disease. While surgery is generally the treatment of choice for these lesions, the population most frequently affected are elderly patients who may not be optimal surgical candidates (16). To confound this, surgical option may also be limited due to the location and size of the lesion.…”

Section: Definitive Rt For Lentiginous Patientsmentioning

confidence: 99%

Radiation Therapy for Melanoma

Shi

2017

Cutaneous Melanoma: Etiology and Therapy

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Although melanoma is a relative radioresistant tumor, radiation therapy (RT) remains a valid and effective treatment option for the management of melanoma. RT as a primary treatment is often offered in well-defined situations, such as medical inoperability, lentiginous melanoma, mucosal melanoma, and ocular melanoma. Adjuvant RT following lymphadenectomy in node-positive melanoma patients prevents local and regional recurrence; however, the role of adjuvant RT remains controversial and underutilized due to lack of overall survival benefit. On the other hand, RT is highly effective in providing symptom palliation for metastatic melanoma and is widely used. Advanced RT technologies such as stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) can achieve excellent local control with minimum toxicities. They are commonly used in the management of brain, lung, spine, and liver metastases. Most recently, it is under active investigation on combining RT with new systemic options, such as targeted therapy, or immunotherapy. The advancements in the treatment of patients with melanoma highlight the importance of multidisciplinary management in this disease. Radiation therapy will continue to be one of the key therapeutic options.

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Section: Definitive Rt For Lentiginous Patientsmentioning

confidence: 99%