Meitoic crossing-over between the X and Y chromosomes of male mice carrying the sex-reversing (Sxr) factor

Evans, E. P.; Burtenshaw, M. D.; Cattanach, B.M.

doi:10.1038/300443a0

Cited by 179 publications

(82 citation statements)

References 11 publications

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“…Sxr (sex-reversed) mice provide a test of this hypothesis. XX Sxr mice do not have a Y chromosome, yet they develop as males because of the presence of a small, sexdetermining portion of the Y, attached to the paternally derived X chromosome (Singh and Jones, 1982;Evans et al, 1982). In these respects, XX Sxr mice are similar to human XX males.…”

Section: Introductionmentioning

confidence: 78%

The sex-determining region of the human Y chromosome encodes a finger protein

Page

Mosher

Simpson

et al. 1987

Cell

821

365

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Section: Introductionmentioning

confidence: 78%

The sex-determining region of the human Y chromosome encodes a finger protein

Page

Mosher

Simpson

et al. 1987

Cell

821

365

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“…To determine the role of meiotic entry on AMH downregulation, we used the XXSxr b mouse model. Male XXSxr b mice develop testes with normal androgenic function, but the presence of two X chromosomes leads to germ cell failure before meiotic entry (12)(13)(14). To identify the level at which AMH regulation takes place, we studied AMH RNA levels in the testes by hybridization analysis, protein production in the Sertoli cells by immunohistochemistry, and protein levels in circulation by a specially developed ELISA for mouse AMH.…”

Section: Introductionmentioning

confidence: 99%

Hormonal and cellular regulation of Sertoli cell anti-Müllerian hormone production in the postnatal mouse.

Al-Attar¹,

Noël²,

Dutertre³

et al. 1997

J. Clin. Invest.

210

152

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Anti-Müllerian hormone (AMH) is secreted by immature testicular Sertoli cells. Clinical studies have demonstrated a negative correlation between serum AMH and testosterone in puberty but not in the neonatal period. We investigated AMH regulation using mouse models mimicking physiopathological situations observed in humans. In normal mice, intratesticular, not serum, testosterone repressed AMH synthesis, explaining why AMH is downregulated in early puberty when serum testosterone is still low. In neonatal mice, AMH was not inhibited by intratesticular testosterone, due to the lack of expression of the androgen receptor in Sertoli cells. We had shown previously that androgeninsensitive patients exhibit elevated AMH in coincidence with gonadotropin activation. In immature normal and in androgen-insensitive Tfm mice, follicle stimulating hormone (FSH) administration resulted in elevation of AMH levels, indicating that AMH secretion is stimulated by FSH in the absence of the negative effect of androgens. The role of meiosis on AMH expression was investigated in Tfm and in pubertal XXSxr b mice, in which germ cells degenerate before meiosis. We show that meiotic entry acts in synergy with androgens to inhibit AMH. We conclude that AMH represents a useful marker of androgen and FSH action within the testis, as well as of the onset of meiosis. ( J. Clin.

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“…If, as hypothesized, a minimum of one chiasma must occur between the PA region of the X and Y chromosomes during male meiosis (see below; ref. 37), size estimates for the PA region would be more accurate when using genetic data obtained from females than males, provided chiasmata formation is uniformly distributed along the paired X chromosomes in females. Data presented here for (B6 X SP)F1 females indicate a genetic distance of 3 cM between the distally positioned X-linked Amg locus and the PA region (as defined by TelXqYq-J and TelXqYq-2).…”

Section: 5mentioning

confidence: 99%

Telomere-related markers for the pseudoautosomal region of the mouse genome.

Eicher¹,

Lee²,

Washburn³

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

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The pseudoautosomal (PA) region of the mammalian genome is the region of the X and Y chromosomes that shares extensive DNA sequence homology and is of special interest because it may play an essential role during male meiosis. We have identified three telomere-related restriction fragments from the PA region of the mouse genome, using an oligonucleotide probe composed of the mammalian telomere consensus sequence TTAGGG. PA assignment of two C57BL/6J-derived fragments was initially suggested by analysis of DNAs from progeny sired by C57BL/6J males carrying the rearranged Y chromosome, Y*: the hybridization intensity of both fragments was concordant with the sex-chromosome complement of the offspring. Further analysis indicated that both fragments were present in female and male F1 mice regardless of the sex oftheir C57BL/6J parent-a criterion for autosomal or PA linkage. Both fragments were closely linked to each other and located on the X chromosome distal to amelogenin (Amg)-in agreement with X or PA linkage. Confirmation of the PA derivation of these fragments was accomplished by following their segregation in a cross involving XY* males mated to DBA/2J females. A similar experiment identified a third PA-derived restriction fragment of LT/SvEi origin. Identification of PA-derived telomere-related restriction fragments will enable further genetic analysis ofthis region of the mouse genome.In 1967, Ohno (1) suggested that the mammalian X and Y chromosomes are derived from a pair of homologous chromosomes, an extension of an hypothesis proposed by Muller (2) for the origin of the sex chromosomes of Drosophila. If this is true, then numerous rearrangements, additions, and deletions must have occurred in the ancestral chromosome that evolved into the mammalian Y chromosome, as the Y chromosome now differs significantly from its putative evolutionary homologue, the X chromosome. However, one area of extensive homology still exists between the mammalian X and Y chromosomes. This shared segment is commonly referred to as the pseudoautosomal (PA) region because PA-derived loci are inherited in a manner characteristic of autosomal loci as a result of obligate crossing over between the X and Y chromosomes during male meiosis (3). In humans the PA region is located at the distal end of the short arms of the X and Y chromosomes, whereas in mice this region is located at the distal end ofthe long arms ofthe X and Y chromosomes (3,4).Although a number of DNA sequences and loci have been mapped to the PA region of the human genome (e.g., ref. 5), to our knowledge only three loci have been mapped to the PA region of the laboratory mouse genome: steroid sulfatase

show abstract

Meitoic crossing-over between the X and Y chromosomes of male mice carrying the sex-reversing (Sxr) factor

Cited by 179 publications

References 11 publications

The sex-determining region of the human Y chromosome encodes a finger protein

The sex-determining region of the human Y chromosome encodes a finger protein

Hormonal and cellular regulation of Sertoli cell anti-Müllerian hormone production in the postnatal mouse.

Telomere-related markers for the pseudoautosomal region of the mouse genome.

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