Hormonal and cellular regulation of Sertoli cell anti-Müllerian hormone production in the postnatal mouse.

Al-Attar, Luma; Noël, Karine; Dutertre, Martin; Belville, Corinne; Forest, Maguelone G.; Burgoyne, Paul S.; Josso, Nathalie; Rey, Rodolfo

doi:10.1172/jci119653

Cited by 210 publications

(171 citation statements)

References 49 publications

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“…The illustration is based on the following references: Josso et al (1993), Lee et al (1996), Schwindt et al (1997), Rajpert-De Meyts et al (1999), Rey et al (1999), Guibourdenche et al (2003), Oppelt et al (2005), Aksglaede et al (2010), Hagen et al (2010), Grinspon et al (2011) and Chong et al (2013). See also Tran et al (1987), Munsterberg & Lovell-Badge (1991), Hirobe et al (1992), Taketo et al (1993) and Al-Attar et al (1997) for information on mice and rats. AMH AMH AMH AMH C AMH N…”

Section: Two Forms Of Amh Exist In the Circulationmentioning

confidence: 99%

Anti-Müllerian hormone is a gonadal cytokine with two circulating forms and cryptic actions

McLennan¹,

Pankhurst²

2015

Journal of Endocrinology

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Anti-Mü llerian hormone (AMH) is a multi-faceted gonadal cytokine. It is present in all vertebrates with its original function in phylogeny being as a regulator of germ cells in both sexes, and as a prime inducer of the male phenotype. Its ancient functions appear to be broadly conserved in mammals, but with this being obscured by its overt role in triggering the regression of the Mü llerian ducts in male embryos. Sertoli and ovarian follicular cells primarily release AMH as a prohormone (proAMH), which forms a stable complex (AMH N,C ) after cleavage by subtilisin/kexin-type proprotein convertases or serine proteinases. Circulating AMH is a mixture of proAMH and AMH N,C , suggesting that proAMH is activated within the gonads and putatively by its endocrine target-cells. The gonadal expression of the cleavage enzymes is subject to complex regulation, and the preliminary data suggest that this influences the relative proportions of proAMH and AMH N,C in the circulation. AMH shares an intracellular pathway with the bone morphogenetic protein (BMP) and growth differentiation factor (GDF) ligands. AMH is male specific during the initial stage of development, and theoretically should produce male biases throughout the body by adding a male-specific amplification of BMP/GDF signalling. Consistent with this, some of the male biases in neuron number and the non-sexual behaviours of mice are dependent on AMH. After puberty, circulating levels of AMH are similar in men and women. Putatively, the function of AMH in adulthood maybe to add a gonadal influence to BMP/GDF-regulated homeostasis.

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Section: Two Forms Of Amh Exist In the Circulationmentioning

confidence: 99%

Anti-Müllerian hormone is a gonadal cytokine with two circulating forms and cryptic actions

McLennan¹,

Pankhurst²

2015

Journal of Endocrinology

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“…Sertoli cells of the testes from embryonic day (E) 12.5 to postnatal day (P) 14 (Supplementary Figure S2, see section on supplementary data given at the end of this article) and then almost repressed by P24 (Al-Attar et al 1997). In the ovary, Amh expression is defined in the growing follicles after P3 and later stages (Lécureuil et al 2002).…”

Section: H3mentioning

confidence: 99%

A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads

Shinomura¹,

Kishi²,

Tomita³

et al. 2014

Reproduction

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Cell ablation technology is useful for studying specific cell lineages in a developing organ in vivo. Herein, we established a novel anti-Mü llerian hormone (AMH)-toxin receptor-mediated cell knockout (Treck) mouse line, in which the diphtheria toxin (DT) receptor was specifically activated in Sertoli and granulosa cells in postnatal testes and ovaries respectively. In the postnatal testes of Amh-Treck transgenic (Tg) male mice, DT injection induced a specific loss of the Sertoli cells in a dose-dependent manner, as well as the specific degeneration of granulosa cells in the primary and secondary follicles caused by DT injection in Tg females. In the testes with depletion of Sertoli cell, germ cells appeared to survive for only several days after DT treatment and rapidly underwent cell degeneration, which led to the accumulation of a large amount of cell debris within the seminiferous tubules by day 10 after DT treatment. Transplantation of exogenous healthy Sertoli cells following DT treatment rescued the germ cell loss in the transplantation sites of the seminiferous epithelia, leading to a partial recovery of the spermatogenesis. These results provide not only in vivo evidence of the crucial role of Sertoli cells in the maintenance of germ cells, but also show that the Amh-Treck Tg line is a useful in vivo model of the function of the supporting cell lineage in developing mammalian gonads.

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“…One effect of 11-KT (or testosterone in mammals) in a complex regulative network is the down-regulation of Amh (Al-Attar et al 1997, Miura et al 2002, Rey et al 2003. Amh, in turn, inhibits LC development and androgen synthesis in mammals (Josso et al 1998, Fynn-Thompson et al 2003, Salva et al 2004).…”

Section: Role Of 11-kt In Stable D-malesmentioning

confidence: 99%

The social status of the male Nile tilapia (Oreochromis niloticus) influences testis structure and gene expression

Pfennig¹,

Kurth²,

Meißner³

et al. 2012

Reproduction

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Dominant and territorial behaviour are known social phenomena in cichlids and social stress influences reproduction and growth. The gonadotropic hormones trigger spermatogenesis and subordinate males have typically lower levels of gonadotropins than dominant males. In this study, we compared testis morphology and gene expression of dominant and subordinate Nile tilapia males (d-and s-males) in socially stable communities. The d-males had the highest gonadosomatic index but they were not the largest animals in the majority of studied cases. Long-term d-males showed large groups of Leydig cells and hyperplasia of the tunica albuginea due to numerous cytochrome-P450-11b-hydroxylase (Cyp11b) expressing myoid cells. Increased Cyp11b expression in d-males was reflected by elevated 11-ketotestosterone plasma values. However, immunofluorescence microscopy and expression analysis of selected genes revealed that most s-males conserved their capability for spermatogenesis and are, therefore, ready for reproduction when the social environment changes. Moreover, in s-males gene expression analysis by quantitative RT-PCR showed increased transcript levels for germ line-specific genes (vasa, sox2 and dmc1) and Sertoli-specific genes (amh, amhrII and dmrt1) whereas gene expression of key factors for steroid production (sf1 and cyp11b) were reduced. The Nile tilapia is a promising model to study social cues and gonadotropic signals on testis development in vertebrates.

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Hormonal and cellular regulation of Sertoli cell anti-Müllerian hormone production in the postnatal mouse.

Cited by 210 publications

References 49 publications

Anti-Müllerian hormone is a gonadal cytokine with two circulating forms and cryptic actions

Anti-Müllerian hormone is a gonadal cytokine with two circulating forms and cryptic actions

A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads

The social status of the male Nile tilapia (Oreochromis niloticus) influences testis structure and gene expression

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