Meibomian gland dysfunction: an overlooked eyelid disease

Turgut, Burak; Çatak, Onur; Demır, Tamer

doi:10.15406/aovs.2018.08.00295

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…Despite its importance in maintaining ocular surface health, MG health is often overlooked clinically. 11 Previous reports of the ocular AE of the FGFR inhibitors mainly focused on the cornea and retina, but the change of MG was not mentioned. [2][3][4] When initiating the therapy, oncologists are actually playing an essential role in educating patients about the potential of AEs.…”

Section: Discussionmentioning

confidence: 99%

Eyes on the Lid: The Impact of Fibroblast Growth Factor Receptor Targeting Drug on Human Meibomian Gland

Chen,

Liu,

Zheng

et al. 2023

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Objective: To determine whether fibroblast growth factor receptor (FGFR)-targeting drug could impact human meibomian gland. Methods: We followed up with three patients who were using pemigatinib for 4 to 10 weeks. The patients were evaluated for their ocular surface disease index, best-corrected visual acuity, Schirmer test, cornea staining, meibum expressibility score, tear meniscus height, noninvasive tear film breakup time, and meibomian gland area. The distribution of the FGFR family, FGF7, and FGF10 were evaluated by immunofluorescence staining and Western blot in fresh tarsal tissues from deidentified patients who underwent lid plastic surgeries. Results: All patients developed apparent meibomian gland atrophy, shortening and narrowing of ducts, and significantly increased meibum expressibility and decreased noninvasive tear film breakup time within 5 to 8 weeks. Laboratory evaluations confirmed that human meibomian gland expresses abundant fibroblast growth factor receptors. Conclusions: These findings indicate that meibomian gland is a target tissue of FGFR inhibitors, and patients who use these drugs may develop meibomian gland dysfunction.

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Section: Discussionmentioning

confidence: 99%

Eyes on the Lid: The Impact of Fibroblast Growth Factor Receptor Targeting Drug on Human Meibomian Gland

Chen,

Liu,

Zheng

et al. 2023

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…La DNS es un trastorno corneal infrecuente, de mayor prevalencia en mujeres mayores de 50 años, asociado a un daño corneal previo [8] ; características que no se corresponden con nuestra paciente, quien tenía 20 años de edad y no tenía antecedentes de lesión traumática o infección ocular reciente.…”

Section: Discussionunclassified

Degeneración nodular de Salzmann en paciente mujer de 20 años de edad: un reporte de caso

2019

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La degeneración nodular de Salzmann es un trastorno corneal no inflamatorio, infrecuente, de mayor prevalencia en mujeres mayores de 50 años. Se caracteriza por la presencia de nódulos blanquecinos en la córnea y está asociada a diversas patologías. Reportamos el caso de una paciente de 20 años con historia de astigmatismo, miopía y síndrome de ovario poliquístico. Acudió a consulta por presentar sensación de cuerpo extraño en el ojo izquierdo y negó el haber padecido infección o trauma ocular recientes. Al examen oftalmológico se evidenció disfunción de las glándulas de Meibomio y nódulos opacos en la periferia de ambas córneas. Los hallazgos clínicos y la tomografía de coherencia óptica confirmaron el diagnóstico de degeneración nodular de Salzmann. El tratamiento con ciclosporina tópica demostró ser efectivo en la disminución de la inflamación causada por la disfunción de las glándulas de Meibomio, lo que evitó recurrencias nodulares a corto plazo.

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“… 16 Eyes with MGD exhibit altered MG secretion that is turbid or cloudy, and tears that are frothy or foamy. 17 Numerous structural changes occur, including thickening, rounding or irregularity of the lid, displacement of the mucocutaneous junction, vascular dilatation, telangiectasia, 18 madarosis or trichiasis, 19 and notching of the lower lid margin. 17 …”

Section: Introductionmentioning

confidence: 99%

Topical review of the relationship between contact lens wear and meibomian gland dysfunction

Ifrah

Quevedo

Gantz

2023

Journal of Optometry

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Meibomian gland dysfunction: an overlooked eyelid disease

Abstract: Clinical findings and diagnosis MGD can present with thickening of the MGs secretions and eyelid margin, turbid secretions, plugged, deformed or cystoid and scarred

Cited by 8 publications

References 22 publications

Eyes on the Lid: The Impact of Fibroblast Growth Factor Receptor Targeting Drug on Human Meibomian Gland

Eyes on the Lid: The Impact of Fibroblast Growth Factor Receptor Targeting Drug on Human Meibomian Gland

Degeneración nodular de Salzmann en paciente mujer de 20 años de edad: un reporte de caso

Topical review of the relationship between contact lens wear and meibomian gland dysfunction

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