Megakaryocytic myelosis with osteosclerosis

Polycythaemia, Leuco-erythroblastosis, and Myelosclerosis

“…Myelocytes in the peripheral blood are rarely numerous. Occasionally, immature white cells have been absent from the blood as in the cases of Hewer (1937), Tudhope (1937, and Heller et al (1947). Bleeding has occurred in several cases both with and without reported decreases in platelets (Hickling, 1937;Thompson and Illyne, 1940;Carpenter and Flory, 1941;and Heller et al, 1947).…”

“…The myelosclerosis has been thought to result from an unknown toxin (Donhauser, 1908), the irritative effect of hyperplastic mveloid tissue (Hewer, 1937), or atrophy of the marrow (Wolf, 1932); it has been found in association with haemolytic anaemia (Wyatt and Sommers, 1950), metastatic carcinomatous deposits (Thompson and Illyne, 1940;Erf and Herbut, 1944), and tuberculosis (Hewer, 1937;Stone and Woodman, 1938). Windholz and Foster (1947) sugge-sted the importance of Rh factor serological studies.…”

Primary Myeloid Metaplasia

“…Secondly, the proliferation of fibrous tissue may be well developed in the spleen and lymph nodes and not confined to the marrow, suggesting the presence of a generalized, fibroproliferative tendency (Jordan and Scott, 1941). Hewer (1937) observed that myelosclerosis was sometimes partial and irregular, and could scarcely have affected the marrow volume in some cases. Further, the frequent occurrence of myeloid metaplasia with excessive production of red cells, white cells, or platelets does not suggest that it is arising in response to a deficiency of cell formation.…”

Clinical Observations on Osteopetrosis and Myelofibrosis

“…In some of these cases the disease may possibly have been associated with marked hyperplasia of the bone marrow-panmyelosis (Hickling28). In other instances, however, this megakaryocytic splenomegaly was associated with fibrosis of various degrees of the marrow, as in the cases of Schwarz, 29 Donhauser,30 Hewer,31 Downey and Nordland 23a and Carpenter and Flory.12 For this reason it might be considered that the picture in some of these cases conforms to the changes observed in osteosclerotic anemia and that the increase of megakaryocytes in the spleen is a sign of active hemopoiesis or myeloid metaplasia. 5.…”