We have explored the patient experience of SSc-RP in a diverse and representative SSc cohort and identified a complex interplay of experiences that result in significant impact. Work to develop a novel PRO instrument for assessing the severity and impact of SSc-RP, comprising domains/items grounded in the patient experiences of SSc-RP identified in this study, is underway.

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Summary. Community samples of 673 subjects who had had serum vitamin B12 concentrations measured in 1958 were followed‐up 10 yr later. 134 of these subjects had died; the death rates showed no consistent trend in relation to the original serum vitamin B12 concentrations. Comparisons of concentrations in 1958 and 1968 in 480 subjects showed correlation coefficients (r) of between 0.46 and 0.71 in various subgroups. The oldest age group had a slightly lower mean concentration, and a larger proportion of this group had values below 100 pg/ml. Several subjects with a consistently low serum vitamin B12 concentration for 10 yr maintained an apparently satisfactory circulating haemoglobin concentration.

Summary: In a 10-year follow-up study of

A panel of five haematologists has examined, without consultation or prior knowledge of the diagnosis, blood films and bone marrow smears from 456 patients with a diagnosis of leukaemia. A diagnostic classification which recognized various subtypes of acute myelogenous leukaemia was used but no attempt was made to subdivide acute lymphoblastic leukaemia. Complete agreement with the initial diagnosis was low (56.4%) and was particularly poor (45.7%) when the patient had one of the forms of acute leukaemia. However, disagreements which would have involved the patient in a change of treatment were unusual (2.0%). We conclude that a high degree of diagnostic agreement for patients with leukaemia is unlikely from morphological classifications alone.

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The serum vitamin B, concentration was estimated in a random sample of two communities; an industrial and an agricultural one. A total of 890 people were studied. The frequency distribution of serum vitamin BI2 concentration shows that the range of values is wide and that the serum vitamin B, level falls with increasing age. For general purposes the results of this study may be summarised by standardking at age 50 years, using the regression coefficient -1.254 p p g per ml per year of age, which summarises the gradient with age over the whole age range studied.Thus the adjusted means and standard errors, 255.2 k 5.45 ppg per ml for the industrial men and 262 5-10.06 p p g per ml for the women, compare closely with the agricultural community where the figures for the men are 260 ?c 9.52 and for the women 272 k 8.45 p p g per ml.