Primary Myeloid Metaplasia

Bowdler, A. J.; Prankerd, T. A. J.

doi:10.1136/bmj.1.5236.1352

Cited by 19 publications

(2 citation statements)

References 10 publications

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“…On the other hand, polycythaemic red cell values have been frequently observed in patients with primary myelofibrosis (e.g. Bowdler & Prankerd 1961, Demidowa 1964, and a patient in whom myelofibrosis antedated polycythaemia has also been reported (Lopas & Josephson 1964). There seems thus to be no doubt about the near relationship between these two diseases which are both generally included in the group of myeloproliferative disorders.…”

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Polycythaemia Vera and Myelofibrosis

Ikkala

Rapola

Kotilainen

1967

Scandinavian Journal of Haematology

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Bone marrow biopsies were made in 63 patients with polycythaemia vera and in three patients with primary myelofibrosis having polycythaemic blood pictures. The histological findings in polycythaemia vera were classified as follows: normal bone marrow in 14, hyperplastic bone marrow in 17, hyperplastic bone marrow with increased reticulin fibers in 19, early myelofibrosis in 9 and advanced myelofibrosis in 4 patients. In 12 of the polycythaemic patients bone marrow biopsy was repeated after nine to 32 months. In eight patients the histological picture was unchanged, three showed progression of myelofibrosis, and in one fibrotic changes possibly due to a miselading biopsy specimen had disappeared. The histological findings were in good correlation with clinical parameters and in only three polycythaemia vera patients with early myelofibrosis in histological specimens no clinical or laboratory signs of myelofibrosis were detected. Myelofibrosis was more often encountered in patients with a long history of polycythaemia vera and at the time of the diagnosis of the disease patients with increase in reticulin fiber content and with myelofibrosis in marrow sections had shown slightly more often leukocytosis, circulating normoblasts and splenomegaly than the other patients. The reliability of bone biopsy from the iliac crest and its value in polycythaemia vera are evaluated. The relationship between polycythaemia vera and myelofibrosis is discussed in the light of the concept of myeloproliferative diseases.

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Polycythaemia Vera and Myelofibrosis

Ikkala

Rapola

Kotilainen

1967

Scandinavian Journal of Haematology

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“…The patient came under the observation of the writer in however, subsequent marrow trephine (and later autopsy) showed that the marrow was normally cellular and the condition could more correctly be described as "primary myeloid metaplasia" (Bowdler and Prankerd 1961). duodenal ulcer also demonstrated could not be implicated in the anaemia.…”

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confidence: 99%