Medicinal use of Coscinium fenestratum (Gaertn.) Colebr.: an short review

Ravishankar, V.; Rajesh, P.; Kim, Hyung-Min

doi:10.1007/s13596-012-0094-y

Cited by 20 publications

(11 citation statements)

References 45 publications

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“…DonguiBogam was published by the royal physician Jun Heo in the Joseon Dynasty of Korea and designated as UNESCO's memory of the world register in 2009 [ 53 ]. Under the contemporary and social requirements, many researchers have made an effort to demonstrate the therapeutic effects of the herbs introduced in those literatures, and found some therapeutic herbs such as Lilium lancifolium , Liriopis tuber , Coscinium fenestratum , and Prunus armeniaca have been proved to have an interesting effect on lung diseases [ 53 – 56 ]. ST has also shown promise as an alternative treatment for lung diseases [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of Stemona tuberosa on lung inflammation in a subacute cigarette smoke-induced mouse model

Lee

Jung

Park

et al. 2014

BMC Complement Altern Med

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BackgroundStemona tuberosa has long been used in Korean and Chinese medicine to ameliorate various lung diseases such as pneumonia and bronchitis. However, it has not yet been proven that Stemona tuberosa has positive effects on lung inflammation.MethodsStemona tuberosa extract (ST) was orally administered to C57BL/6 mice 2 hr before exposure to CS for 2 weeks. Twenty-four hours after the last CS exposure, mice were sacrificed to investigate the changes in the expression of cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), chemokines such as keratinocyte-derived chemokine (KC) and inflammatory cells such as macrophages, neutrophils, and lymphocytes from bronchoalveolar lavage fluid (BALF). Furthermore, we compared the effect of ST on lung tissue morphology between the fresh air, CS exposure, and ST treatment groups.ResultsST significantly decreased the numbers of total cells, macrophages, neutrophils, and lymphocytes in the BALF of mice that were exposed to CS. Additionally, ST reduced the levels of cytokines (TNF-α, IL-6) and the tested chemokine (KC) in BALF, as measured by enzyme-linked immunosorbent assay (ELISA). We also estimated the mean alveolar airspace (MAA) via morphometric analysis of lung tissues stained with hematoxylin and eosin (H&E). We found that ST inhibited the alveolar airspace enlargement induced by CS exposure. Furthermore, we observed that the lung tissues of mice treated with ST showed ameliorated epithelial hyperplasia of the bronchioles compared with those of mice exposed only to CS.ConclusionsThese results indicate that Stemona tuberosa has significant effects on lung inflammation in a subacute CS-induced mouse model. According to these outcomes, Stemona tuberosa may represent a novel therapeutic herb for the treatment of lung diseases including COPD.

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Section: Discussionmentioning

confidence: 99%

Inhibitory effects of Stemona tuberosa on lung inflammation in a subacute cigarette smoke-induced mouse model

Lee

Jung

Park

et al. 2014

BMC Complement Altern Med

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“…Coscinium fenestratum Used in Ayurvedic medicine for diabetes, poultice, cuts, sores, ulcers, (Nekaris et al 2005) fever, jaundice, snake bites (Rai et al 2013 diabetes. Beneficial for eye disorders and insect bites.…”

Section: Tardigradusmentioning

confidence: 99%

Medicinal plant exudativory by the Bengal slow loris Nycticebus bengalensis

Das¹,

Nekaris²,

Bhattacharjee³

2014

Endang. Species. Res.

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Slow lorises are members of a rare guild of obligate exudativores. Secondary metabolites in their diet have been implicated as contributing to the evolution of both their slow basal metabolism and their venom. No long-term study has yet examined the feeding ecology of the largest of the lorises, the Bengal slow loris Nycticebus bengalensis. We conducted an 18 mo study from June 2008 to December 2010 in Hollongapar Gibbon Wildlife Sanctuary, Assam, India, to investigate whether Bengal slow lorises prefer gum, and whether there is any evidence of secondary metabolites in their diet. We detected the lorises along line transects using existing trails and followed each animal as long as possible, recording selected behaviours via focal instantaneous sampling. We recorded 629 feeding incidents during 270 night walks. We found that up to 80.9% of feeding bouts were of plant exudates, followed by bark, floral parts, insects, fruits, and tender (i.e. immature) leaves. Within the plant exudate category, 5 species were consumed in 71% of the total exudate feeding bouts: Terminalia chebula, Mesua ferrea, T. arjuna, Ficus hispida and Dillenia indica. These species all have high medicinal value and are commonly used by the local communities for traditional medicinal purposes. Absorption of secondary metabolites from these plants may explain unusual healing patterns observed in wild slow lorises, but lacking in lorises held in captivity. Their dietary affinity towards medicinal plants could explain patterns of use of slow lorises within the traditional medicine trade in the Indo-Chinese region. 23: 149-157, 2014 to-digest secondary metabolites (Heymann & Smith 1999). Only 6 primate genera (Calithrix, Mico, Ce buella, Phaner, Euoticus and Nycticebus) are known to access these foods through active excavation of plant surfaces (Starr & Nekaris 2013). These obligate exudativores include exudates in ≥40% of their feeding time (hereafter referred to as diet; Nash & Burrows 2010). KEY WORDS: Lorisidae · Exudativory · Feeding ecology · Secondary metabolite · India Resale or republication not permitted without written consent of the publisher Contribution to the Theme Section 'Conservation and ecology of slow lorises' FREE REE ACCESS CCESSEndang Species ResUntil the mid-1990s, virtually nothing was known about the feeding ecology of wild slow lorises (Nycticebus spp.), and the discovery that these small primates consumed large quantities (comprising nearly 40 to 90% of the diet) of exudates was surprising; indeed it had been predicted that like the similarly non-leaping pottos of Africa, loris diet would comprise mainly fruits (Ravosa 1998). Several morphological characters of these nocturnal strepsirrhines suggest the presence of obligate exudativory, including a stout toothcomb, small body size, a large caecum, a long tongue, wide U-shaped legs and enlarged hand pads for gripping (Hladik 1978. Wiens et al. (2006), Swapna et al. (2009) and Starr & Nekaris (2013) all provided strong evidence that exudates are a preferred ...

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“…For snake bite poisoning, paste of C. fenestratum and turmeric is applied. C. fenestratum is reported to have anticancer, antimicrobial, antidiabetic, and antioxidant effect and is also used to treat cholera, gastroenteritis, and bleeding piles [ 14 – 16 ]. The seeds of C. sativum and stem of C. fenestratum have previously been shown to have anti-inflammatory activity when tested alone and as ethanolic concoctions of individual ingredients [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Activity of a Traditional Sri Lankan Concoction of Coriandrum sativum L. and Coscinium fenestratum G.

Kothalawala

Edward

Harasgama

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the immunomodulatory activity of a traditional Sri Lankan concoction of Coriandrum sativum L. and Coscinium fenestratum (Gaertn.) Colebr., which is a Sri Lankan traditional medicine used to relieve inflammation and cold. Methods. In vivo anti-inflammatory activity was tested using carrageenan-induced rat paw-edema model. Mechanism of anti-inflammatory activity was assessed by investigating the production of nitric oxide (NO), expression of iNOS enzyme, and reactive oxygen species (ROS) by rat peritoneal cells. The membrane stabilizing activity was also tested. The antibody response was determined by assessing the specific haemagglutination antibodies raised against sheep red blood cells. Results. The three doses of freeze-dried concoction used ((human equivalent dose (HED)—183 mg/kg) 2 × HED and 1/2HED; n = 6 rats/group) showed significant inhibition of paw edema compared to water control at 3rd–5th hours (p<0.05). Both HED and 1/2HED exhibited marked anti-inflammatory activity (72–83% inhibition at 4th-5th hours; p<0.05). The HED of the concoction showed significant inhibition of NO (77.5 ± 0.73%, p<0.001) and ROS production (26.9 ± 2.55%; p<0.01) by rat peritoneal cells. Inhibition of NO production in the concoction treated rat peritoneal cells was confirmed by the lack of iNOS expression. The concoction also exhibited significant membrane stabilizing activity (IC50 = 0.0006 μg/ml; p=0.001). HED resulted in a significantly high induction of specific antibody production against SRBC antigens as detected by SRBC haemagglutination assay (mean day 14 titers 253.3 compared to control: 66.7) (p<0.01). Conclusions. The traditional Sri Lankan concoction of C. sativum and C. fenestratum demonstrated potent in vivo anti-inflammatory activity, significant reduction of ROS, and NO production by rat peritoneal cells and the lack of iNOS expression confirmed the low NO production. The increased membrane stability also supports the anti-inflammatory activity of the concoction. Further, this concoction induced a significantly high antibody response reflecting its immunostimulatory activity. Together these results scientifically validate the therapeutic use of the concoction of C. sativum and C. fenestratum in Sri Lankan traditional medicinal system for immunomodulatory effects.

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Medicinal use of Coscinium fenestratum (Gaertn.) Colebr.: an short review

Cited by 20 publications

References 45 publications

Inhibitory effects of Stemona tuberosa on lung inflammation in a subacute cigarette smoke-induced mouse model

Inhibitory effects of Stemona tuberosa on lung inflammation in a subacute cigarette smoke-induced mouse model

Medicinal plant exudativory by the Bengal slow loris Nycticebus bengalensis

Immunomodulatory Activity of a Traditional Sri Lankan Concoction of Coriandrum sativum L. and Coscinium fenestratum G.

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