Medicinal species with gastroprotective activity found in the Brazilian Cerrado

Martins, José Luís Rodrigues; Rodrigues, Oscar Romero Lopes; Sousa, Fábio Borges de; Fajemiroye, James Oluwagbamigbe; Galdino, Pablinny Moreira; Florentino, Iziara Ferreira; Costa, Élson Alves

doi:10.1111/fcp.12113

Cited by 23 publications

(11 citation statements)

References 101 publications

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“…The plants of this genus present bioactive compounds, which confirms the effectiveness of some traditional medicine indications [60]. There are several scientific works that indicate gastroprotective activity, phytochemical and antimicrobial activity, anti-inflammatory and antioxidant action, as well as antidiarrheal and healing properties for duodenal and gastric ulcers [61–64]. However, a recent study about the genus Hymenaea spp.…”

Section: Resultsmentioning

confidence: 99%

Plants used by the rural community of Bananal, Mato Grosso, Brazil: Aspects of popular knowledge

et al. 2019

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Studies in rural communities are important to maintain popular knowledge between generations, as well as to identify new species for pharmaceutical production. Thus, the objectives of this study were to determine which plant species the rural community of Bananal, Mato Grosso, Brazil, uses by calculating the levels of fidelity and concordance regarding species uses among residents and to determine if there is a relationship between the number of known useful plants and levels of education, age, and residence time. Ethnobotanical data was collected from residents of the community through semi-structured interviews in January/December/2016. Species diversity was calculated using Shannon-Wiener, Level of Fidelity (LF), Correction Factor, and the Percentage of Agreement regarding the Main Uses (AMU). Statistical tests were performed using generalized linear models (GLM) in the R environment. The plant use indications were grouped according to the International Classification of Diseases and Related Health Problems (ICD 10). We found 152 species belonging to 130 genera and 67 families. The most frequently used plant parts were leaves, and decoction was the most frequent preparation mode. Strychnos pseudoquina was the species with the highest amount of use indications. The diversity index was 4.5 nats/ind-1. The body system with the most citations was the code XVIII of ICD 10, corresponding to the species: alfavaca, mentraste, terramicina, angelim, fedegoso. Medicinal species with AMU values higher than 25% were: Strychnos pseudoquina, Plectranthus barbatus, Citrus sinensis cv. pera, Cymbopogon citratus. There was a relationship between the number of useful plants and the residence time of the participants. The Bananal community revealed high species richness and the relationship of knowledge showed that the older the residents and the longer their residence time in the community, the more knowledge they acquired.

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Section: Resultsmentioning

confidence: 99%

Plants used by the rural community of Bananal, Mato Grosso, Brazil: Aspects of popular knowledge

et al. 2019

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“…[1][2][3] Due to its large size and great variety of climate and biomes, Brazil has a high biodiversity popularly used to treat different diseases. 4,5 These biological properties are attributed to the secondary metabolite contents, which are ecologically important for the plant to protect against solar radiation, and microbial and herbivore attacks. 6,7 Their accumulation in plants is described in the literature, as being influenced by changes in the environmental conditions, such as temperature, sunlight, water availability, pollution, nutrients, herbivore and microbial attacks and others.…”

Section: Introductionmentioning

confidence: 99%

Spatial and Temporal Variations in Secondary Metabolites Content of the Brazilian Arnica Leaves (Lychnophora ericoides Mart., Asteraceae)

Gobbo‐Neto¹,

Bauermeister²,

Sakamoto³

et al. 2017

J. Braz. Chem. Soc.

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The genus Lychnophora (Asteraceae) is a medicinal plant traditionally used as anti-inflammatory or analgesic agent. Its biological properties have been widely investigated and correlated with its chemical composition, which could be different between the species and even accordingly to the place and season of collection. In this work, it was investigated the spatial and temporal variations in the secondary metabolites from five populations of Lychnophora ericoides. Among them, a more diversified secondary metabolism was observed for the plants collected at Ibiraci-MG (Brazil), a city placed between two biomes, Cerrado and Atlantic Forest. The highest concentrations of chlorogenic acids were found in the Cerrado dry season (winter), while the flavonoids were higher during the rainy season (summer). Significant reduction was observed in the contents of all the secondary metabolites in old leaves, and also in flowery branches. These variations detected in L. ericoides leaves could highly influence the intensity of the biological activities of this plant.Keywords: Lychnophora ericoides, Asteraceae, traditional medicine, seasonal variation, secondary metabolites IntroductionTraditional medicine was and has been widely applied around the world for promoting health, and along the history, many drugs have been isolated from medicinal plants. [1][2][3] Due to its large size and great variety of climate and biomes, Brazil has a high biodiversity popularly used to treat different diseases. 4,5 These biological properties are attributed to the secondary metabolite contents, which are ecologically important for the plant to protect against solar radiation, and microbial and herbivore attacks. 6,7 Their accumulation in plants is described in the literature, as being influenced by changes in the environmental conditions, such as temperature, sunlight, water availability, pollution, nutrients, herbivore and microbial attacks and others. [8][9][10] As a strategy to adapt and survive under damaging conditions, plants use many complex biochemical processes to create chemical defense mechanisms, and this behavior cannot be neglected in pharmacology of medicinal plants. Thus, there are many phytochemical studies evaluating seasonal effects in the bioactive secondary metabolite production, [11][12][13] and relating their importance to the environment, 8 to understand the behavior of these plants.The genus Lychnophora (from Asteraceae family) is a plant endemic in Brazil, that has been used as a prospective source of natural products.14 This plant usually grows in the Cerrado, where are found only few arboreous and herbaceous species. 15 Some species of Lychnophora are extensively used in traditional Brazilian herbal medicine as anti-inflammatory, as well as analgesic, antimicrobial and anti-rheumatism agent. 16More specifically, L. ericoides, known as "arnica da serra" or "falsa arnica", is popularly used orally for medical purposes in the form of hydroalcoholic extracts prepared by macerating its leaves with cachaça ("aguardente"). ...

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“…Mucus is one of the most important parameters that contribute to the protection of gastric mucosa. Gastric mucus is responsible for the first line of defense of the gastric mucosa and consists of a transparent viscous, elastic, adherent gel that is made up of water and glycoproteins (Martins et al, 2015). The mucus layer is a physical barrier that adheres together with bicarbonate and protects the underlying mucosa from proteolytic digestion (Allen and Flemstrom, 2005).…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effect of the aqueous fraction of hydroacetonic leaf extract of Eugenia uniflora L. (Myrtaceae) (pitanga) against several gastric ulcer models in mice

Rodrigues¹,

Da²,

Oluwagbamigbe³

et al. 2017

J. Med. Plants Res.

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Eugenia uniflora L. (Myrtaceae) is popularly known in Brazil as pitanga or ibitanga. The infusion of E. uniflora leaves is being used in folk medicine as anti-diarrheal. The present study sought to evaluate the gastroprotective potential of the aqueous fraction of hydroacetonic leaf extract of pitanga (AFHP). The leaf powder of pitanga was extracted with 50% acetone using an overhead stirrer apparatus at room temperature in which the acetone was removed under reduced pressure and the suspended aqueous. The aqueous layer was freeze-dried to yield a 122 g aqueous fraction, which was stored at-20°C. Preliminary investigation showed that AFHP (100, 300 and 1000 mg/kg, p.o.) is devoid of any behavioral neurotoxic signs. The anti-ulcer activity of AFHP was evaluated in the gastric ulcer models induced by indomethacin, stress and HCl/EtOH in mice. In order to identify possible mechanisms of gastroprotective activity of AFHP, antisecretory activity of this fraction was conducted. The quantification of adhered gastric mucus reduced glutathione (GSH) and the role of nitric oxide (NO) were also investigated. The AFHP showed antiulcer activity in various models of acutely induced ulcers. The intra-duodenal administration of this fraction reduced total acidity and increased pH of the gastric secretion. Oral administration prevented a decrease in the amount of adhered mucus and increased GSH levels. Pretreatment with L-NAME did not affect the gastroprotective effect of AFHP. Our results suggest that AFHP exhibits antiulcer activity that involved an increased in gastric mucus and in the levels of GSH.

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Medicinal species with gastroprotective activity found in the Brazilian Cerrado

Cited by 23 publications

References 101 publications

Plants used by the rural community of Bananal, Mato Grosso, Brazil: Aspects of popular knowledge

Plants used by the rural community of Bananal, Mato Grosso, Brazil: Aspects of popular knowledge

Spatial and Temporal Variations in Secondary Metabolites Content of the Brazilian Arnica Leaves (Lychnophora ericoides Mart., Asteraceae)

Gastroprotective effect of the aqueous fraction of hydroacetonic leaf extract of Eugenia uniflora L. (Myrtaceae) (pitanga) against several gastric ulcer models in mice

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