Medicinal Plants with Potential Wound Healing Activity

Borkar, Vijay S.; Kumaran, Senthil K.; Kumar, Senthil K Praveen

doi:10.5958/0975-4385.2015.00020.5

Cited by 4 publications

(1 citation statement)

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“…Dilaporkan bahwa Axonopus Compressus berkhasiat sebagai antidiabetes dan memiliki kandungan metabolit sekunder yaitu steroid, alkaloid, flavonoid, saponin, tanin dan antrakuinon dan glikosida jantung [1]. Digitaria ciliaris memiliki aktivitas fitotoksik dan fitokimia utama yang ditemukan dalam genus Digitaria adalah terpenoid, minyak atsiri, alkaloid, flavonoid, fenolik dan juga tanin [2]. Kandungan metabolit sekunder yang ada pada Axonopus compressus dan Digitaria ciliaris merupakan senyawa-senyawa yang dapat bermanfaat sebagai sumber obat dan antioksidan.…”

Section: Pendahuluanunclassified

Profil Kromatografi Lapis Tipis Antioksidan Tumbuhan Gulma: Axonopus compressus (Sw.) P. Beauv and Digitaria ciliaris (Retz.) Koeler

Mersi,

Sinthary,

Rijai

2023

Proc. Mul. Pharm. Conf.

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Weeds are plant species that grow around cultivated crops and are often considered unwanted nuisance plants because they are considered harmful. These weeds, which are often considered a nuisance, can be utilised, especially as a source of medicine. Many studies have presented information on the benefits of weed plants as a source of treatment for degenerative diseases. This study aims to determine the secondary metabolite compounds contained in Axonopus compressus and Digitaria ciliaris weed plants through thin layer chromatographic (KLT) profiles. Extraction was carried out by maceration using methanol solvent and the yield value of Axonopus compressus extract was 3.01% and Digitaria ciliaris extract was 3.27%. The KLT profile test obtained secondary metabolite groups of Axonopus compressus and Digitaria ciliaris methanol extracts, namely flavonoids, alkaloids, steroids/terpenoids, saponins, and tannins. Qualitative test of antioxidant activity using DPPH method on KLT plates of methanol extracts of Axonopus compressus and Digitaria ciliaris obtained positive results of yellow stains with RF values of 0.6; 0.65 and 0.7 which indicate the presence of compounds that have antioxidant activity. Keywords: Axonopus compressus, Digitaria ciliaris, thin layer chromatography, antioxidant Abstrak Gulma merupakan spesies tumbuhan yang tumbuh disekitar tanaman budidaya dan sering dianggap sebagai tumbuhan pengganggu yang tidak diinginkan karena dianggap merugikan. Tumbuhan gulma yang sering dianggap mengganggu ini dapat dimanfaatkan khususnya sebagai sumber pengobatan. Telah banyak Penelitian yang menyajikan informasi mengenai manfaat tumbuhan gulma sebagai sumber pengobatan penyakit degeneratif. Penelitian ini bertujuan untuk mengetahui senyawa metabolit sekunder yang terkandung pada tumbuhan gulma Axonopus compressus and Digitaria ciliaris melalui profil kromatografi lapis tipis (KLT). Ekstraksi dilakukan dengan cara maserasi menggunakan pelarut metanol dan didapatkan hasil nilai rendemen ekstrak Axonopus compressus sebesar 3.01% dan ekstrak Digitaria ciliaris sebesar 3,27%. Uji profil KLT didapatkan golongan metabolit sekunder ekstrak metanol Axonopus compressus dan Digitaria ciliaris yaitu flavonoid, alkaloid, steroid/terpenoid, saponin, dan tanin. Uji kualitatif aktivitas antioksidan menggunakan metode DPPH pada plat KLT ekstrak metanol Axonopus compressus dan Digitaria ciliaris didapatkan hasil positif noda berwarna kuning dengan nilai RF 0,6; 0,65 dan 0,7 yang menunjukkan adanya senyawa yang mempunyai aktivitas antioksidan. Kata Kunci: Axonopus compressus, Digitaria ciliaris, kromatografi lapis tipis, antioksidan

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Section: Pendahuluanunclassified

Profil Kromatografi Lapis Tipis Antioksidan Tumbuhan Gulma: Axonopus compressus (Sw.) P. Beauv and Digitaria ciliaris (Retz.) Koeler

Mersi,

Sinthary,

Rijai

2023

Proc. Mul. Pharm. Conf.

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Evaluation of Cutaneous Wound Healing Activity of Citrus aurantium Fruit Peel Extract-based Ointment in Albino Rats

Cherukuri

Paramanayagam²,

Prabakaran

et al. 2023

RJPT

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The current study was aimed to evaluate the wound healing activity of ethyl acetate extract of fruit peels of Citrus aurantium. An ethyl acetate extract of fruit peel of Citrus aurantium was loaded into an ointment base with three different concentrations (0.25% w/w, 0.5% w/w and 1%w/w) and tested for wound healing activity using excision wound model by measuring the healing area and dermal toxicity. Wound healing activity and histopathology studies confirmed that all the tested three concentrations of extract accelerate the wound healing process by decreasing the surface area of the wound and increases the muscle tensile strength. Out of tested ointments, 5% w/w concentration showed comparative activity with the standard. Hence, natural Citrus aurantium peel-based ointment is an alternative ointment in wound healing.

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In-silico Screening of Potential Phytochemicals against Extracellular Adherence (Eap) Protein of Staphylococcus aureus from Indian Medicinal Plants

Zeenat,

Prajapati,

Sangeet

et al. 2023

RJPT

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Background: Staphylococcus aureus is a threat to human health, it colonizes one-third of the human population via skin or nose and deeper intrusions into tissues have catastrophic consequences. The bacterium secretes virulence proteins like CHIP and SCIN and extracellular adhesins like extracellular adherence (Eap) proteins. Eap and its functionally orphan homologs, EapH1 and EapH2; are a class of secreted proteins that inhibit neutrophil serine proteases such as neutrophil elastase (HNE) that is linked to tissue degradation in a variety of disease conditions including inflammatory disorders. Commercial drugs used against S.aureus such as Nafcillin, Pefloxacin, etc. have been known to have negative effects and are not recommended for children, the elderly, or pregnant women. Objective: The current research focuses on discovering phytochemicals found in Indian medicinal herbs that have been used as spices for ages and are already beneficial against a variety of illnesses and ailments to be used against Eap proteins. Method: Molecular docking;absorption, distribution, metabolism, excretion, toxicity (ADMET) analysis and Simulation were performed to see if these phytochemicals interact with the active site residues of Eap proteins and function as competitive inhibitors of NE and to know their drug like properties and gather information about the system dynamics. 19 phytochemicals were selected from receptor-ligand docking. The selected molecules were pharmacologically tested through Lipinski’s analysis; to know their ability for being formulated into drugs. ADMET analysis was carried out to define the biological characteristic of phytochemicals inside the living body. The phytochemicals with the best docking score and drug likeliness were analysed by Molecular Simulation to observe the fluctuation of participating and interacting amino acids with Eaph1 and Eaph2 respectively. Result: Among the nineteen phytochemicals that were chosen for docking only the best eleven interactions were chosen for ADMET analysis. The top hit phytochemicals for Eaph1 and Eaph2 were Curcumin and Eugenol respectively, which was well demonstrated by Molecular dynamic simulation. Conclusion: The present study has established the hypothesis that phytochemicals have a scope to replace commercial drugs against the Eap virulence system of Staphylococcus aureus

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Medicinal Plants with Potential Wound Healing Activity

Cited by 4 publications

References 0 publications

Profil Kromatografi Lapis Tipis Antioksidan Tumbuhan Gulma: Axonopus compressus (Sw.) P. Beauv and Digitaria ciliaris (Retz.) Koeler

Profil Kromatografi Lapis Tipis Antioksidan Tumbuhan Gulma: Axonopus compressus (Sw.) P. Beauv and Digitaria ciliaris (Retz.) Koeler

Evaluation of Cutaneous Wound Healing Activity of Citrus aurantium Fruit Peel Extract-based Ointment in Albino Rats

In-silico Screening of Potential Phytochemicals against Extracellular Adherence (Eap) Protein of Staphylococcus aureus from Indian Medicinal Plants

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