Medicinal plants useful for treating chronic obstructive pulmonary disease (COPD): Current status and future perspectives

Ram, Arjun; Balachandar, Selvakumar; Vijayananth, Pavadai; Singh, V.R.

doi:10.1016/j.fitote.2010.09.005

Cited by 60 publications

(29 citation statements)

References 92 publications

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“…EO has been traditionally used to treat respiratory tract disorders including bronchitis, pharyngitis and sinusitis. The scientific interest on medical plants in treating chronic pulmonary disease is expanding [30].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats

Wang¹

2017

JDMP

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Eucalyptus oil (EO), an essential oil isolated from Eucalyptus leaves, was examined for its effect on LPS andKlebsiella pneumoniae -induced COPD in rats. The COPD model was induced by instilling intratracheally with LPS and Klebsiella pneumoniae (K. P). The test compound, EO (30, 100 and 300 mg/kg), Prednisone Acetate (10 mg/kg) or vehicle was instilled intragastrically after three weeks exposure of LPS and K. P, lasted for 4 weeks. EO significantly reduced amounts of inflammatory cells in bronchoalveolar lavage fluid (BALF) and blood, and decreased bronchiolitis, emphysematous changes and thickness of bronchioles. It also significantly reduced the increased AB-PAS-positive goblet cells in bronchioles. Prednisone Acetate attenuated pulmonary inflammation and airway mucus hypersecretion, but no significant difference was found on emphysema. Pretreatment with EO markly reduced the production of proinflammatory cytokines TNF-α and IL-β in lung homogenate, significantly decreased the elevated malondialdehyde (MDA) level and and increased superoxide dismutase (SOD) activity. These findings indicate that EO could exert an protective effect against LPS plus K. P-induced lung indury via inhibition of proinflammatory cytokines production and improvement of anti-oxidant status. Our results provide evidence that EO might have its potential to be a proper candidate drug in the treatment of COPD.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats

Wang¹

2017

JDMP

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“…Many medicinal plants have been reported to have the medicinal effect for COPD. These medicinal natural products affect the pulmonary inflammation through traditional medication and experimental studies (Kim et al, 2011;Ram et al, 2011;Lim and Kim, 2012). LL has also been reported to have the anti-inflammatory effects (Xia et al, 2012).…”

Section: 생쥐에서 급성 폐렴에 대한 여정자 열매 추출물의 억제효과mentioning

confidence: 99%

Section: 생쥐에서 급성 폐렴에 대한 여정자 열매 추출물의 억제효과mentioning

confidence: 99%

“…TNF-α is thought to play a key role in acute pulmonary inflammation, and it is expressed by neutrophils and T lymphocytes (Ram et al, 2011). In addition, TNF-α expression is associated with the infiltration of inflammatory cells (Ram et al, 2011). IL-6, an inflammatory and fibrogenic cytokine, also plays a critical role in the development of pulmonary inflammation and in the fibrotic process in lung tissue (Song et al, 2001).…”

Section: 생쥐에서 급성 폐렴에 대한 여정자 열매 추출물의 억제효과mentioning

confidence: 99%

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Ligustrum lucidum Fruits Extract Inhibits Acute Pulmonary Inflammation in Mice

Kwak

Lim²

2013

Korean Journal of Medicinal Crop Science

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: Traditionally, Ligustrum lucidum fruits (LL) is one of the well-known oriental herb used in the treatment of skin and lung inflammation. This study investigated anti-inflammatory effects of LL in the pathogenesis of acute pulmonary inflammation in mice. Acute pulmonary inflammation was induced by intratracheal instillation of cigarette smoke condensate (CSC) and lipopolysaccharide (LPS) 5 times within 12 days in mice. LL extract was administered orally at a dose of 50 or 200 ㎎/㎏. Administration of LPS and CSC significantly elevated airway hyperresponsiveness (AHR) to mice, and increased in the levels of inflammatory cells and mediators in mice. However, the LL extract significantly reduced the elevated AHR, and the increase of neutrophils, CD4 + /CD3+ cells and CD8 + /CD3 + cells, along with reducing the expression of TNF-α, IL-6, and MIP-2. Moreover, the LL extract alleviated the infiltration of inflammatory cells in expanded airway walls histologically. These results indicate that the LL extract has an inhibitory effects on acute pulmonary inflammation and AHR in murine model, and plays a crucial role as a immunomodulator which possess anti-inflammatory property.

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“…These samples represented natural populations of coltsfoot from different regions of Poland ( Fig. 1): Western Pomerania (localities 1-2), the Lubusz region (3), Greater Poland (4)(5)(6)(7)(8)(9)(10)(11)(12), Upper Silesia and Dąbrowa Basin (13)(14)(15), Lesser Poland (16)(17)(18), and the Cieszyn Silesia (19)(20). The investigated populations of T. farfara occurred in different types of habitats, mainly anthropogenic ones such as roadsides and roadside ditches as well as fallow lands.…”

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confidence: 99%

Content of pyrrolizidine alkaloids in the leaves of coltsfoot (Tussilago farfara L.) in Poland

et al. 2013

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Coltsfoot (Tussilago farfara L.) is a common species, widely used in European and Chinese traditional medicine for the treatment of respiratory diseases. However, raw material from this plant contains hepatotoxic pyrrolizidine alkaloids (PAs). The aim of the study was to determine the variability of the level of PAs (senkirkine and senecionine) in leaves of coltsfoot originated from natural populations in Poland. In the phytochemical analysis, 20 samples of T. farfara were used. This plant material was obtained from the Garden of Medicinal Plants in Plewiska near Poznań and originated from different regions of Poland. Coltsfoot leaves were harvested in the middle of July of 2010 and then dried at room temperature. The alkaloid content was detected using the HPLC-DAD method. The amount of PAs in leaves of T. farfara changed in a wide range from 0.06 to 1.04 μg g−1 of dry matter (DM). The content of senkirkine and senecionine was positively correlated (r = 0.68, P = 0.001). There was no statistically significant correlation between the amount of PAs as well as leaf weight and water content in leaves of T. farfara. Our results showed that a medium-sized leaf of coltsfoot (0.33 g DM) may contain from 0.02 to 0.34 μg of PAs (on average 0.14 μg). The level of PAs was not associated with the region of Poland, but phytochemical similarity of samples was usually visible at the local scale. Coltsfoot leaves are characterized by a high variability of the content of toxic PAs, much higher than in the case of the main active compounds, especially flavonoids and mucilage. This phytochemical variability is mainly genetically determined (samples came from a garden collection), and it can be increased by environmental factors. Our investigations indicate that Polish natural populations of T. farfara may provide raw material with a low level of toxic PAs.

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Medicinal plants useful for treating chronic obstructive pulmonary disease (COPD): Current status and future perspectives

Cited by 60 publications

References 92 publications

Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats

Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats

Ligustrum lucidum Fruits Extract Inhibits Acute Pulmonary Inflammation in Mice

Content of pyrrolizidine alkaloids in the leaves of coltsfoot (Tussilago farfara L.) in Poland

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