Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats

Abstract

Eucalyptus oil (EO), an essential oil isolated from Eucalyptus leaves, was examined for its effect on LPS andKlebsiella pneumoniae -induced COPD in rats. The COPD model was induced by instilling intratracheally with LPS and Klebsiella pneumoniae (K. P). The test compound, EO (30, 100 and 300 mg/kg), Prednisone Acetate (10 mg/kg) or vehicle was instilled intragastrically after three weeks exposure of LPS and K. P, lasted for 4 weeks. EO significantly reduced amounts of inflammatory cells in bronchoalveolar lavage fluid (BALF) and blood, and decreased bronchiolitis, emphysematous changes and thickness of bronchioles. It also significantly reduced the increased AB-PAS-positive goblet cells in bronchioles. Prednisone Acetate attenuated pulmonary inflammation and airway mucus hypersecretion, but no significant difference was found on emphysema. Pretreatment with EO markly reduced the production of proinflammatory cytokines TNF-α and IL-β in lung homogenate, significantly decreased the elevated malondialdehyde (MDA) level and and increased superoxide dismutase (SOD) activity. These findings indicate that EO could exert an protective effect against LPS plus K. P-induced lung indury via inhibition of proinflammatory cytokines production and improvement of anti-oxidant status. Our results provide evidence that EO might have its potential to be a proper candidate drug in the treatment of COPD.

Modulation of cigarette smoke extract-induced human bronchial epithelial damage by eucalyptol and curcumin

“…16 Previous reports with EUC were mainly focused on its repair capacity on pulmonary tissue by reducing oxidative stress and lipid peroxidation, preventing/reducing activation of inflammatory cytokines with limited in vivo or in vitro studies. [17][18][19] On the other hand, curcumin (CUR), is a well-known dietary and polyphenolic compound related to significantly enhanced pulmonary function due to its antioxidant and anti-inflammatory capacity. 15,20 However, the efficacy of EUC and CUR combination on CS-induced bronchial epithelial toxicity has not been studied yet.…”