Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Abstract

Recently, numerous side effects of synthetic drugs have lead to using medicinal plants as a reliable source of new therapy. Pain is a global public health problem with a high impact on life quality and a huge economic implication, becoming one of the most important enemies in modern medicine. The medicinal use of plants as analgesic or antinociceptive drugs in traditional therapy is estimated to be about 80% of the world population. The Lamiaceae family, one of the most important herbal families, incorporates a wide variety of plants with biological and medical applications. In this study, the analgesic activity, possible active compounds of Lamiaceae genus, and also the possible mechanism of actions of these plants are presented. The data highlighted in this review paper provide valuable scientific information for the specific implications of Lamiaceae plants in pain modulation that might be used for isolation of potentially active compounds from some of these medicinal plants in future and formulation of commercial therapeutic agents.

Evaluation of Antibacterial Activity of Lavandulapedunculata subsp. atlantica (Braun‐Blanq.) Romo Essential Oil and Selected Terpenoids against Resistant Bacteria Strains–Structure–Activity Relationships

“…These secondary metabolites are used in various industries such as cosmetics, agri‐food and pharmaceutical industries. These plants are well‐known for their use in traditional medicine to treat several diseases thanks to their various biological potentialities due to their richness in natural compounds . The genus Lavandula is used in traditional or modern medicines for the treatment of several gastrointestinal, analgesic, anti‐inflammatory, nervous and rheumatic disorders .…”

Recent Advances in the Analysis of Rosmarinic Acid From Herbs in the Lamiaceae Family

“…), lemon balm (Melissa officinalis L.), marjoram (Origanum majorana L.), oregano (Origanum vulgare L.), peppermint (Mentha × piperita L.), rosemary (Rosmarinus officinalis L.), sage (Salvia officinalis L.), and thyme (Thymus vulgaris L.). 2,3 Lamiaceae species have been used in traditional medicine for the treatment of depression, headache, asthma, 4 stress, 5 and respiratory 6 and Alzheimer's diseases. 7,8 In addition, these plants have antioxidant, 9 antiallergic, 10 antimicrobial, 11 anticarcinogenic, 12 anti-inflammatory, 13 astringent, 14 and antiHIV-1 effects.…”

The Imidazoline Receptor Antagonists Idazoxan and Efaroxan Improve the Spatial and Reference Memory in Rats

“…A new (+) 2-(Ethyl-2,3dihydrobenzofuranyl)-2-imidazoline derivative dexefaroxan, the (+) enantiomer of efaroxan, a potent and selective á2 antagonist, has demonstrated a facilitator effect on the cognitive functions in the passive avoidance test, in rats with scopolamine-induced memory deficit [27][28][29][30]. Moreover, dexefaroxan showed to increase the memorizing performance in passive avoidance test, to improve the spatial memory in Morris swimming test in rats, and to increase the performance of the object recognition, in the specific behavior model in mice [31][32][33][34]. It also improves the cognitive functions in knockout mice with Alzheimer disease [35].…”