Evaluation of Antibacterial Activity of Lavandulapedunculata subsp. atlantica (Braun‐Blanq.) Romo Essential Oil and Selected Terpenoids against Resistant Bacteria Strains–Structure–Activity Relationships

Abstract

The genus Lavandula is known for its different uses in traditional medicine. This study is interested in the chemical composition of Lavandulapedunculata subsp.atlantica (BRAUN-BLANQ.) ROMO as well as evaluating its antibacterial potential against multi-resistant strains. The analysis of Lavandulaatlantica essential oil (LAEO) allows the identification of 47 components representing 93.6 % of all identified. The main constituent of LAEO was camphor (50.4 %), followed by fenchone (14.1 %) and camphene (5.6 %). The antibacterial assays revealed that LAEO was active against all the studied bacteria. A preliminary study of the relationship between certain terpenoids and antibacterial activity was also carried out in order to note the compound(s) that are responsible for LAEO's antibacterial activity. This study showed that the activity of the essential oil may be due to the presence of certain minor compounds such as carvone, considering the presence of the synergistic effect between the essential oil.

The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections

“…Most of the terpenes reported are known and their multiple chiral centers were assigned according to the literature. When chirality is not reported, terpenes were tested as racemic form (see Table 3) [103,107,126,129]. In some studies, the authors investigated the extract chemical composition by Gas Chromatography-mass spectrometry (GC/MS) [129].…”

“…When chirality is not reported, terpenes were tested as racemic form (see Table 3) [103,107,126,129]. In some studies, the authors investigated the extract chemical composition by Gas Chromatography-mass spectrometry (GC/MS) [129]. The chemical structure of the most representative terpenes examined in this review is shown in Table 3.…”

“…Interestingly, the efficiency of geraniol in reducing drug resistance was also observed towards β-lactams and the fluoroquinolone norfloxacin highlighting that geraniol modulates antibiotic resistance in Gram(−) bacteria by targeting efflux pumps mechanisms [130]. Recently, Sayout et al evaluated the antibacterial activity and the chemical composition of the essential oils from two species of the genus Lavandula: L. tenuisecta Coss.exBall and Lavandula pedunculata subsp.atlantica (BRAUN-BLANQ) [129,135]. Essential oils from both species showed antibacterial activity against several microorganisms leading to an increased interest for Lavandula genus in the treatment of bacterial infections caused by MDR strains.…”

“…Several other oxygenated monoterpenes isolated from Lavandula atlantica essential oil showed a strong antimicrobial activity against most of the studied strains. Among them, linalool (Table 3, compound 3), an acyclic monoterpene alcohol, with MIC values ranging from 1.44 µg/mL to 3.83 µg/mL; terpinen-4-ol (Table 3, compound 4), a cyclic monoterpene alcohol, with MIC values ranging from 0.78 µg/mL to 3.13-6.25 µg/mL; borneol (Table 3, compound 5), a bicyclic monoterpene alcohol, with MIC values ranging from 0.47 µg/mL to 3.75 µg/mL; and fenchone (Table 3, compound 6), a bicyclic monoterpene ketone, with MIC values ranging from 1.06 µg/mL to 4.25 µg/mL [129,135].…”

Characterization of an Endemic Plant Origanum grosii from Morocco: Trace Element Concentration and Antihyperglycemic Activities

“…On the other hand, the advantages of medicinal plants are enormous, especially in the pharmacological sector by discovering new components coming from natural sources to fight against several diseases [15][16][17][18]. Besides, to determine the chemical profile and composition of medicinal plants, several studies show the complexity and variety of compounds that all contribute to the various uses of plants in the processing of many foods, including life-threatening diseases such as AIDS, cancer, and diabetes [2,19].…”