Medicinal plants of India with anti-diabetic potential

Histological changes and antidiabetic activities of Icacina trichantha tuber extract in beta–cells of alloxan induced diabetic rats

“…They are better than allopathic drugs, which have a lot of adverse side effects [23] . For testing antidiabetic potential of plants, alloxan and streptozotocin induced hyperglycemia in rats is considered to be a good preliminary screening model and is widely used [24] .…”

An overview on antidiabetic medicinal plants having insulin mimetic property

“…The beneficial effects of SACS could be due to its antioxidant and secretagogues activity [11,16] . Daily oral feeding of garlic extracts at 100 mg/kg increased plasma insulin level with concomitant decrease in plasma glucose levels [10] . Effect of aqueous garlic (10% v/v) extracts on isolated pancreas were shown to potentiate glucose-induced insulin secretion [17] .…”

“…Berberine can enhance glucose-stimulated insulin secretion in rat islets, and probably exerts the insulinotropic effect via a pathway involving hepatic nuclear factor 4 alpha (HNF4) alpha and glucokinase, which is distinct from sulphonylureas [21] . Significant insulin sensitizing activity was observed in 3T3-L1 adipocytes which were given 50 毺 M berberine plus 0.2 nM insulin to reach a glucose uptake level increased by 10 nM of insulin alone. This was associated with increased glucose transporter-4 translocation into the plasma membrane via enhancing insulin signalling pathways and the insulin receptor substrate-1-phosphoinositide 3 KinaseAkt.…”

“…Several such herbs have shown antidiabetic activity when evaluated using different type of experimental techniques. Wide arrays of plant derived active principles representing different type of biological activity, among these alkaloids, glycosides, galactomannan gun, polysaccharides, peptidoglycans, hypoglycans, guanidine, steroids, carbohydrates, glycopeptides, terpenoids, amino acids and inorganic ions have demonstrated activity including treatment of diabetes [10] . List of the medicinal plants having antidiabetic potential acording to the different part used and mode of action were presented in Table 1 and Table 2.…”

Assessment of glycemic potential ofMusa paradisiaca stem juice

“…Many synthetic oral hypoglycemic agents, such as Biguanides and sulfonylurea are available along with insulin for the treatment of diabetes mellitus. In the indigenous system of medicine many plants have been claimed to be useful in the treatment of diabetes mellitus (1)(2)(3)(4). Musa paradisiaca (Family: Musaceae) is a perennial tree like herb.…”