Medicinal Plants and Its Pharmacological Values

Bhat, Smita

doi:10.5772/intechopen.99848

Cited by 15 publications

(10 citation statements)

References 13 publications

(6 reference statements)

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“…They are considered an invaluable source of potential therapeutic agents, modern drugs, nutraceuticals, dietary supplements, folk remedies and pharmaceutical intermediates; many are used as precursors to synthetic drugs and modern therapeutic approaches [ 42 , 43 , 44 ]. It is estimated that about 30% of higher plant species are used in medicine, and that 74% of pharmacologically-active compounds of plant origin were discovered based on their ethnomedical uses [ 42 , 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico

Sitarek

Kowalczyk

Synowiec

et al. 2022

Cells

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Plectranthus ornatus Codd, the genus Plectranthus of the Lamiaceae family, has been used as traditional medicine in Africa, India and Australia. Pharmacological studies show the use of this plant to treat digestive problems. In turn, leaves were used for their antibiotic properties in some regions of Brazil to treat skin infections. The present study examines the anti-inflammatory, antioxidant and cytotoxic effects of the halimane and labdane diterpenes (11R*,13E)-11-acetoxyhalima-5,13-dien-15-oic acid (HAL) and 1α,6β-diacetoxy-8α,13R*-epoxy-14-labden-11-one (PLEC) and the forskolin-like 1:1 mixture of 1,6-di-O-acetylforskolin and 1,6-di-O-acetyl-9-deoxyforskolin (MRC) isolated from P. ornatus on lung (A549) and leukemia (CCRF-CEM) cancer cell lines, and on normal human retinal pigment epithelial (ARPE-19) cell line in vitro. Additionally, molecular docking and computational approaches were used. ADMET properties were analysed through SwissADME and proTox-II—Prediction. The results indicate that all tested compounds significantly reduced the viability of the cancer cells and demonstrated no cytotoxic effects against the non-neoplastic cell line. The apoptosis indicators showed increased ROS levels for both the tested A549 and CCRF-CEM cancer cell lines after treatment. Furthermore, computational studies found HAL to exhibit moderate antioxidant activity. In addition, selected compounds changed mitochondrial membrane potential (MMP), and increased DNA damage and mitochondrial copy number for the CCRF-CEM cancer cell line; they also demonstrated anti-inflammatory effects on the ARPE-19 normal cell line upon lipopolysaccharide (LPS) treatment, which was associated with the modulation of IL-6, IL-8, TNF-α and GM-CSF genes expression. Docking studies gave indication about the lowest binding energy for 1,6-di-O-acetylforskolin docked into IL-6, TNF-α and GM-CSF, and 1,6-di-O-acetyl-9-deoxyforskolin docked into IL-8. The ADMET studies showed drug-likeness properties for the studied compounds. Thus, halimane and labdane diterpenes isolated from P. ornatus appear to offer biological potential; however, further research is necessary to understand their interactions and beneficial properties.

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Section: Discussionmentioning

confidence: 99%

An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico

Sitarek

Kowalczyk

Synowiec

et al. 2022

Cells

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“…This is due to their greater compatibility, cultural appropriateness and adaptation with human/animal body, as well as the fact that they have less adverse effects (Hassan, 2012). The curative properties of medicinal plants are due to presence of major group of active components which are mainly phytochemicals like flavonoids, tocopherols, santonins, choline, tannins, carotenoids, folic acid, ascorbic acid, benzoic acid and cinnamic acid (Mahapatra et al, 2019;Bhat, 2021;Faheem et al, 2022). Iwu (2002) reported several drugs derived from ethnobotanical leads, for example, Curcumin from Curcuma longa, Asiticoside canescens from Centella asiatica etc.…”

Section: Mikania Micrantha Hbkmentioning

confidence: 99%

“…Iwu (2002) reported several drugs derived from ethnobotanical leads, for example, Curcumin from Curcuma longa, Asiticoside canescens from Centella asiatica etc. In the case of human pharmacognosy which lead to development of modern drugs based on laboratory tests, lots of studies are available but in veterinary science such information is scarce (Bhat, 2021). Bharti and Sharma (2012) reported the same plant used for human and veterinary treatment, for example Cannabis sativa, Drymaria cordata etc.…”

Section: Mikania Micrantha Hbkmentioning

confidence: 99%

Uncodified system of animal health care in Eastern Himalaya and Indo-Burma hotspots of India: Plant use and their distribution

JHA,

JHA

2023

Nova Geodesia

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Northeastern states, Sikkim, Arunachal Pradesh, Assam, Meghalaya, Nagaland, Manipur, Mizoram and Tripura – falling in Eastern Himalaya and Indo-Burma hotspots, house a large number of indigenous communities, mostly forest and forest fringe dwellers, whose economy is also dependent on livestock. To maintain the health of various livestock they practice ethnoveterinary medicine (EVM) which is so important yet scarcely studied. This review is based on eleven core research publication on EVM practices representing these states. Several other peer reviewed publications were also consulted for analysis and synthesis of the contents like, Physiography and Phyto-diversity, Indigenous Communities, Livestock and Common Ailments, Healer Plants, Bio-Active Components and Drugs, Potential Distribution. Analysis revealed that only twenty-three communities out of >200 are researched upon. All most all the livestock are covered in the studied area by using herbal preparation from 195 plants. However, research on pharmacological and distributional details is scanty and needs further exploration since similar plants (Asparagus racemosus, Allium sativum, Azadirachta indica, Cannabis sativa, Centella asiatica, Curcuma longa, Drymaria cordata) for ethnomedicine use (for humans) are recorded from various locations and used by different communities. Nevertheless, current compilation of data seems to be useful in the sense of preservation of the indigenous knowledge, otherwise on decline due to oral transfer from one to another generation.

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“…The therapeutic use of plants can be traced back to the Sumerian civilization, and according to the World Health Organization, 75% of the global population are using traditional, plant-based medicines for primary healthcare. [1][2][3] In addition, natural actives are increasingly used in cosmetic and personal care products.…”

Section: Introductionmentioning

confidence: 99%

Non‐destructive, reverse iontophoretic extraction of phytochemicals from Mangifera indica, Centella asiatica, Punica granatum, and Citrus sinensis

Eilstein

Nair

Moore

et al. 2023

Phytochemical Analysis

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For the commercial‐scale isolation of phytochemicals, a suitable plant biomass source (including species, origin, growing season, etc.) must be identified, and frequent analytical verification is required to ensure that the phytochemicals are present at predefined minimum threshold concentrations. While the latter are typically assessed in the laboratory, a more efficient and less resource‐intensive approach would involve non‐destructive and environmentally friendly measurements in situ. Reverse iontophoretic (RI) sampling offers a potential solution to this challenge. Objective We aimed to demonstrate the non‐destructive, RI sampling of phytochemicals of interest from biomass from four different sources. Materials and methods RI experiments were performed in side‐by‐side diffusion cells using a current density of 0.5 mA/cm2, for a predetermined time in a defined pH environment, using (1) fresh leaves from Mangifera indica and Centella asiatica and (2) isolated peel from Punica granatum and Citrus sinensis. Results Mangiferin, madecassoside, punicalagin, ellagic acid, and hesperidin were extracted from the different biomasses by RI. The amounts extracted ranged from 0.03 mg/100 mg of biomass for the cathodal extraction of madecassoside to 0.63 mg/100 mg of biomass for the anodal extraction of punicalagin. A linear relationship (r2 = 0.73) between the RI‐extracted quantities of punicalagin and those determined using conventional methods was demonstrated. Conclusion The non‐destructive, in situ measurement of phytochemical levels by RI represents a feasible approach for timing the harvesting process.

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Medicinal Plants and Its Pharmacological Values

Cited by 15 publications

References 13 publications

An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico

An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico

Uncodified system of animal health care in Eastern Himalaya and Indo-Burma hotspots of India: Plant use and their distribution

Non‐destructive, reverse iontophoretic extraction of phytochemicals from Mangifera indica, Centella asiatica, Punica granatum, and Citrus sinensis

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