Medicinal Foodstuffs. IV. Fenugreek Seed. (1): Structures of Trigoneosides Ia, Ib, IIa, IIb, IIIa, and IIIb, New Furostanol Saponins from the Seeds of Indian Trigonella foenum-graecum L.

Yoshikawa, Masayuki; Murakami, Toshiyuki; Komatsu, Hajime; Murakami, Nobutoshi; Yamahara, Johji; Matsuda, Hisashi

doi:10.1248/cpb.45.81

Cited by 127 publications

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“…Fenugreek seeds are commonly used as condiment and seasoning in food preparation and are assumed to possess nutritive properties (Renuka et al 2009). In addition, seeds were used as tonic and lactagogue (Basch et al 2003) as well as for treatment of weakness and edema of legs (Yoshikawa et al 1997). Several studies indicated the hypoglycemic and hypolipidemic properties of fenugreek seeds (Renuka et al 2009) suggesting that fenugreek may help to control diabetes (Basch et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Fenugreek potent activity against nitrate-induced diabetes in young and adult male rats

et al. 2014

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Nitrate has described as an endocrine disruptor that promotes onset of diabetes. This study was undertaken to evaluate diabetic effect of high nitrate intake in young and adult male rats and its amelioration by fenugreek administration. The study revealed significant increase in serum glucose and blood glycosylated hemoglobin (HbA1c%), while serum insulin and liver glycogen were decreased among nitrate exposed animals, in particular the young group. A significant reduction in the body weight gain and serum thyroid hormones (T4 & T3) was also recorded. Further reduction in serum levels of urea and creatinine, as well as total protein in serum, liver and pancreas was demonstrated, with elevation in their levels in the urine of all nitrate exposed groups. Meanwhile, the activity of serum transaminases (ALT and AST) was increased, with decline in their activity in the liver tissue. In addition, an elevation in serum total bilirubin, tissues (liver and pancreas) nitric oxide and lipid profile, as well as liver activity of glucose-6-phosphatase was recorded. Fenugreek administration to nitrate exposed rats was found to be effective in alleviating hyperglycemia and other biochemical changes characterizing nitrate-induced diabetes. So, fenugreek can be considered to possess potent activity against onset of nitrate induced-diabetes.

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Section: Introductionmentioning

confidence: 99%

Fenugreek potent activity against nitrate-induced diabetes in young and adult male rats

et al. 2014

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“…Several such claims were confirmed experimentally. Various pharmacologically active compounds such as alkaloids (Shani et al, 1974;Duke, 2001;Zhao et al, 2003;Satheeshkumar et al, 2010); flavonoids (Adamska and Lutomski, 1971;Shang et al, 1998); tannin like phenolic compounds (Duke, 2001); polyphenols (Kaviarasan et al, 2008); steroids (Taylor et al, 1997); saponins (Dawidar et al, 1973;Pasich et al, 1983;Gupta et al, 1986;Yoshikawa et al, 1997;Sauvaire et al, 1998;Murakami et al, 2000;Raju et al, 2004;Yang et al, 2005); dioscin; free amino acids (Duke, 2001); an unusual amino acid 4-hydroxyisoleucine (Haefelé et al, 1997;Sauvaire et al, 1998;Haeri et al, 2009); coumarin derivatives (Khurana et al, 1982); lipids (Beutler and Der Marderosian, 2002); phospholipids (Xu et al, 1992); mucilaginous fibers (Srichamroen et al, 2009); vitamins; and minerals have been isolated from fenugreek seeds (Farnsworthand Marles, 1995;Duke, 2001). Some of the steroidal saponins isolated from fenugreek seeds, were found to stimulate growth-hormone release in rat pituitary cells (Shim et al, 2008), while higher phenol and polyphenols contents of fenugreek controlled oxidative damage (Kaviarasan et al, 2007;Dixit et al, 2008;Kaviarasan et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

Al-Ashban¹,

Abou‐Shaaban²,

Shah³

2010

Oriental Pharmacy and Experimental Medicine

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SUMMARYAcute (24 h) and chronic (90 days) oral toxicity studies on the ethanol extract of Trigonella foenumgraecum Leguminosae (L.) seeds were carried out. Acute dosages were 0.5, 1.0 and 3 g/kg while chronic dosage was 100 mg/kg per day of the extract. All morphological, biochemical, haematological and spermatogenic changes, in addition to mortality, body weight changes and any change in vital organs were recorded. Histopathological investigations were done on vital organs. Growth arrest in the treated animals was observed. The treated mice gained no significant weight during chronic treatment while there was a significant gain in body weight of the control group mice. Biochemical studies revealed a significant decrease in blood sugar levels of fenugreek treatment groups while haematological parameters remained comparable to the control. In the treatment, male group there was a significant decrease in weight of testes as compared to the control. There was a marginal weight gain in kidney weight of mice after chronic treatment as compared to the control. Fenugreek chronic treatment caused a highly significant spermatotoxic effects in male mice.

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“…Several confections made with this the article are recommended for use in dyspepsia with loss of appetite, in the diarrhea of puerperal women, and in rheumatism. [25] www.wjpr.net Vol 6, Issue 6, 2017.…”

Section: Medicinal Usesmentioning

confidence: 99%

Formulation and Evaluation of Ibuprofen Suspension Using Natural and Synthetic Suspending Agents

Ponnada¹

2017

WJPR

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Medicinal Foodstuffs. IV. Fenugreek Seed. (1): Structures of Trigoneosides Ia, Ib, IIa, IIb, IIIa, and IIIb, New Furostanol Saponins from the Seeds of Indian Trigonella foenum-graecum L.

Cited by 127 publications

References 0 publications

Fenugreek potent activity against nitrate-induced diabetes in young and adult male rats

Fenugreek potent activity against nitrate-induced diabetes in young and adult male rats

Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

Formulation and Evaluation of Ibuprofen Suspension Using Natural and Synthetic Suspending Agents

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