Fenugreek potent activity against nitrate-induced diabetes in young and adult male rats

Abstract

Nitrate has described as an endocrine disruptor that promotes onset of diabetes. This study was undertaken to evaluate diabetic effect of high nitrate intake in young and adult male rats and its amelioration by fenugreek administration. The study revealed significant increase in serum glucose and blood glycosylated hemoglobin (HbA1c%), while serum insulin and liver glycogen were decreased among nitrate exposed animals, in particular the young group. A significant reduction in the body weight gain and serum thyroid hormones (T4 & T3) was also recorded. Further reduction in serum levels of urea and creatinine, as well as total protein in serum, liver and pancreas was demonstrated, with elevation in their levels in the urine of all nitrate exposed groups. Meanwhile, the activity of serum transaminases (ALT and AST) was increased, with decline in their activity in the liver tissue. In addition, an elevation in serum total bilirubin, tissues (liver and pancreas) nitric oxide and lipid profile, as well as liver activity of glucose-6-phosphatase was recorded. Fenugreek administration to nitrate exposed rats was found to be effective in alleviating hyperglycemia and other biochemical changes characterizing nitrate-induced diabetes. So, fenugreek can be considered to possess potent activity against onset of nitrate induced-diabetes.

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

“…The effects of curcumin in cardiovascular diseases are linked to its ability to (1) inhibit platelet aggregation [58], (2) inhibit inflammatory response [59], (3) lower LDL and elevate HDL [60], (4) inhibit fibrinogen synthesis [61], and (5) inhibit oxidation of LDL [62]. A review on the effect of curcumin on number of CVD risk factors is provided, which attempts to explain how this plant product acts to prevent development of CVD in the obese states [63].…”

Fenugreek, A Potent Hypoglycaemic Herb Can Cause Central Hypothyroidism Via Leptin – A Threat To Diabetes Phytotherapy

“…fenugreek seed extract fT 3 free triiodothyronin fT 4 free dicinal herb with potent antihyperglycaemic and hypoglycaemic effects, is used to treat diabetes. This study is aimed to explore the interaction of fenugreek seed extract (FSE) and HPT (hypothalamic-pituitary-thyroid) axis in context of leptin secretion which have important role in normal and type-1 diabetic subjects.…”

“…Fenugreek seed extracts (FSE) showed hypoglycaemic and anti-hyperglycaemic effects in both experimentally induced diabetic animals [3] and type-1, type-2 diabetic human trials [4]. It also mitigated diabetes-related other metabolic disorders [5].…”

Integrative and comparative reproductive biology: From alligators to xenobiotics

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