Medical Therapy of Peptic Ulcer Disease

McQuaid, Kenneth R.; Isenberg, Jon I.

doi:10.1016/s0039-6109(16)45680-x

Cited by 19 publications

(12 citation statements)

References 69 publications

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“…Due to the presence of H2 receptors in organs such as lung and heart, the H2-receptor antagonists have other minor physiological effects but their primary indication is the inhibition of histaminemediated gastric acid secretion. To a lesser extent, the H2receptor antagonists will also inhibit gastrin and cholinergicmediated acid secretion (Bertaccini & Coruzzi, 1988;Parsons, 1991;McQuaid & Isenberg, 1992).…”

Section: Introductionmentioning

confidence: 99%

Plasma pharmacokinetics of ranitidine HCl in adult horses

Holland

Ruoff

Brumbaugh

et al. 1997

Vet Pharm & Therapeutics

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Plasma pharmacokinetics of ranitidine HCl were investigated after intravenous (i.v.) and oral (p.o.) administration of 2.2 mg/kg drug to six healthy adult horses. Concentrations of ranitidine were determined using normal-phase, high-performance liquid chromatography. Plasma concentrations of ranitidine HCl declined from a mean of 5175 ng/mL at 5 min to 37 ng/mL at 720 min after i.v. administration. A three-exponent equation, Cp = A1 x e-k1t + A2 x e-k2t + A3 x e-k3t, best described data for all horses. Mean values for model-independent values calculated from the last quantifiable time point were: apparent volume of distribution (Vdss) = 1.07 L/kg; area under the curve (AUC) = 231,000 ng.min/mL: area under the moment curve (AUMC) = 26,900,000 ng.min2/mL; mean residence time (MRT) = 113 min; and clearance (Cl) = 9.8 mL/min.kg. Following p.o. administration, a two-exponent equation, Cp = A1 x e-k1t + A2 x e-k2t, best described the data for five horses: data for the remaining horse were best described by a three-exponent equation. Mean values of pharmacokinetic values from the p.o. study include: AUC = 59,900 ng x min/mL; AUMC = 10,600,000 ng x min2/mL; mean absorption time (MAT) = 58.9 min: Tmax = 99.2 min; Cmax = 237 ng/mL: and F = 27%.

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Section: Introductionmentioning

confidence: 99%

Plasma pharmacokinetics of ranitidine HCl in adult horses

Holland

Ruoff

Brumbaugh

et al. 1997

Vet Pharm & Therapeutics

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“…Rutin (100 mg/kg) increased slightly pH, as compared to control, but did not affect the gastric secretion and acid output. Gastric ulcer seems to be caused from over-secretion of gastric juice and imbalance of defensive, and aggressive factors involved in maintaining gastric mucosal integrity (McQuaid and Isenberg, 1992). The formation of gastric mucosal lesions by necrotizing agents such as HCl and ethanol has been known to be associated with the depression of gastric defensive mechanisms (Kinoshita et al, 1995).…”

Section: Resultsmentioning

confidence: 99%

Evaluation for Protective Effect of Rutin, a Natural Flavonoid, against HCl/Ethanol-Induced Gastric Lesions

Jeong

2009

Biomolecules and Therapeutics

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-In this study we investigated the protective effects of rutin, a natural plant flavonoid, on HCl/ethanol-induced gastric lesions in rats. Rutin showed the antioxidant activities, the acid-neutralizing capacities, and the inhibitory effects on the growth of Helicobacter pylori (H. pylori.), which are equivalent to control compounds. In addition, rutin significantly inhibited HCl/ethanol-induced gastric lesions. Antigastritic action of rutin may be associated with the antioxidant activities, acid-neutralizing capacities, anti-H. pylori action, and the stimulation of mucus secretion. From these results, we could suggest that rutin may be useful for the treatment and/or protection of gastritis.

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“…Gastric ulcer seems to be caused from over-secretion and an imbalance of defensive and aggressive factor (McQuaid and Isenberg, 1992). Butanol fraction showed the augmentation of mucus content as a defensive factor and antioxidant activity.…”

Section: Discussionmentioning

confidence: 97%