Medical and Surgical Applications of Collagen

Chvapil, Miloš; Kronenthal, L; W, Van Winkle

doi:10.1016/b978-0-12-363706-2.50007-6

Cited by 225 publications

(79 citation statements)

References 113 publications

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“…Resorbable forms of collagen are used to dress oral wounds and for closure of graft and extraction sites. In fact, M. Chvapil et al described the use of films made from hydrolyzed collagen as tissue adhesives for suture replacement due to their chemical resemblance to connective tissue and their tissue fluid-binding properties [318]. Collagen-based membranes are also used in periodontal and implant therapy as barriers to prevent epithelial migration and allow cells with regenerative capacity to repopulate the defect area creating a favorable environment for cellular development.…”

Section: Proteins and Poly(amino Acids)mentioning

confidence: 99%

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Section: Proteins and Poly(amino Acids)mentioning

confidence: 99%

Biodegradable polymers for dental tissue engineering and regeneration

Conte¹,

Riccitiello²,

Luise³

et al. 2017

Biodegradable Polymers: Recent Developments and New Perspectives

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“…It is to be noted that at 90 days post operation, animals maintained a 60% and a 80% deficit in NCV in autograft and collagen+CSF groups, respectively. The decreased NCV is one of the effect of the loss of larger diameter fibers, a phenomenon reported in other traumatic nerve lesions (10). There is an idea that the walking track analysis is more comprehensive and reliable than histomorphometric methods in peripheral nerve repair studies (14).…”

Section: Sciatic Functional Index (Sfi)mentioning

confidence: 99%

The effect of cerebro-spinal fluid in collagen guide channel on sciatic nerve regeneration in rat

Farjah

Dolatkhah²,

Pourheidar³

et al. 2015

Turkish Neurosurgery

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ABSTRACTgaps by inserting the severed nerve stumps into the two ends of the canal (16). Some natural and synthetic substances can be shaped in structures that are able to promote nerve regeneration for example: eggshell membrane (12), silicone (31), human amnion layer (22), collagen (18), collagen-Chitosan (36).Collagen-based biomaterials have been extensively studied as a promising nerve guide (7). Since collagen is a natural material, it shows excellent biocompatibility, insignificant immunogenicity, and high bio-absorbability (27).█ INTRODUCTION F or peripheral nerve repair, nerve autografts have always been considered as the "gold standard" for the restoration of structural and functional nerve regeneration (34).Autograft has several disadvantages, including the need for an extra-incision, loss of donor nerve function, mismatch in size between the donor nerve and the injured nerve, and a limited availability of donor nerve (33). To solve these problems, nerve guide channels (NGCs) have been made to bridge the nerve AIm: The aim of this study was to evaluate the effect of cerebrospinal fluid (CSF) in nerve regeneration across the collagen guide channel in comparison with autograft. mATERIAl and mEThODS: Forty adult male rats (250-300 g) were randomized into (1) collagen channel+CSF, (2) collagen channel+normal saline (NS), (3) autograft, and (4) sham surgery groups. The left sciatic nerve was exposed and a 10 mm nerve segment was cut and removed. In the collagen groups, the proximal and distal cuts ends of sciatic nerve were telescoped into the nerve guides and CSF or NS injected into collagen conduit. In the autograft group, the 10 mm nerve segment was turned backwards and used an autologous nerve graft. All animals were evaluated by sciatic functional index (SFI) and electrophysiology, histology, and immunohistochemistry testing. RESUlTS:The improvements in SFI since the beginning of the last evaluation in experimental groups were measured. On days 49 and 60 post-operation, the mean SFI of the collagen+CSF group was significantly greater than the autograft group (P< 0.05). On day 90, the mean nerve conduction velocity (NCV) of the collagen+CSF group was greater than autograft group (P< 0.05). The number of myelinated fibers in the collagen+CSF group was significantly greater than that of the collagen + NS group at day 90 (P<0.05).CONClUSION: CSF in collagen nerve guide channel effectively enhances nerve regeneration and promotes functional recovery in injured sciatic nerve of rats.

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“…[22] Biological dressings are the logical best candidate for the management of wounds since they create the most physiological interface between the wound surface and the environment. [23] Collagen is a biological skin substitute, i.e. natural, easily available, ready to use, non-immunogenic, and non-pyrogenic.…”

Section: Collagen As a Biomaterials In Plastic And Reconstructive Surgerymentioning

confidence: 99%

Collagen membrane for reconstruction of soft tissue defects after surgery of oral cancer and precancer: a brief review

Vastani¹,

Chourasia²,

Pahlajani³

et al. 2016

PAR

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There are some surgeries after which a temporary cover for raw wounds is required to ensure healing. Some of those circumstances are loss of tissue due to burns, trauma, amputation, chronic ulcer, leprosy, and skin graft sites. Although the body initiates regeneration mechanisms, however the time taken for complete healing of wounds is unpredictable. Also, there is a tendency for long standing wounds to undergo infection and scarring. Oral mucosa is no exception to scarring and infection of wounds and there has always been a search for new materials that can be used for coverage of oral defects. Xenogenous collagen is one such grafting material. Over the years collagen implant solutions for a number of clinical applications include general surgery, burn surgery, neurosurgery, plastic and reconstructive surgery, oral surgery, and peripheral nerve and tendon surgery. This paper aims to focus on collagen as an effective option of wound closure in plastic and reconstructive surgery of the head and neck, especially after loss of soft tissue following resection of oral malignancies.

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Medical and Surgical Applications of Collagen

Cited by 225 publications

References 113 publications

Biodegradable polymers for dental tissue engineering and regeneration

Biodegradable polymers for dental tissue engineering and regeneration

The effect of cerebro-spinal fluid in collagen guide channel on sciatic nerve regeneration in rat

Collagen membrane for reconstruction of soft tissue defects after surgery of oral cancer and precancer: a brief review

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