Medicago sativa L., a functional food to relieve hypertension and metabolic disorders in a spontaneously hypertensive rat model

Martínez, R.; Kapravelou, Garyfallia; Porres, Jesús M.; Melesio, Adela M.; Heras, L. de las; Cantarero, Samuel; Gribble, Fiona M.; Parker, Helen; Aranda, Pilar; López-Jurado, Marı́a

doi:10.1016/j.jff.2016.08.013

Cited by 19 publications

(15 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in M. minima, the leaves contained more TFC compared to the roots and stems, unlike M. sativa 26 . Hence, there is a difference in the distribution of the phenolic compounds in the plants' organs of neighbouring and non-neighbouring species [24][25][26][27][28] . Furthermore, the large variability in TFC in the roots may reflect the interaction between M. minima plants and their environment (soil).…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, most studies have only focused only medicinal and aromatic plants 5,15,17,23 , whereas some species have so far remained unexplored. Furthermore, most of the studies have been interested in the biochemical composition of one or two plant parts 13,[23][24][25] , a focus that can omit a piece of fascinating information about the studied species. To better determine the values of unknown Medicago species in scientific research and the development of medicinal resources, it is necessary to investigate their phenolic composition in all plant parts.…”

Section: Influence Of Climate Variation On Phenolic Composition and Amentioning

confidence: 99%

See 1 more Smart Citation

Influence of climate variation on phenolic composition and antioxidant capacity of Medicago minima populations

Kabtni

Sdouga

Rebey

et al. 2020

Sci Rep

View full text Add to dashboard Cite

as mean ± standard deviation of triplicate experiments. In order to compare the four organs and to prove that the differences between these organs are not an accident or due to a chance, we utilised the Kruskal-Wallis test. This test rejects the hypothesis that the organs are from identical populations. Moreover, we used ANOVA (at a significant level of p < 0.05) coupled with multiple comparisons of means (Tukey Contrasts) to investigate: the differences between different organ assays and to compare selected M. minima populations. In addition, we completed discriminative analysis, namely PCA, for each organ by the using TPC as a matrix. We evaluated the association between variables by the Pearson correlation method. The levels and the statistical analysis (ANOVA, Kruskal-Wallis test and Tukey test) are shown in Supplementary Tables S1, S2. We used R (version 3.5.1) for all statistical analyses. The utilised packages were: Agricolae, Rcmdr, car, RcmdrMisc, corrplot, tidyverse, hrbrthemes, ggplot2 and RColorBrewer 68-71 .

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Influence Of Climate Variation On Phenolic Composition and Amentioning

confidence: 99%

Influence of climate variation on phenolic composition and antioxidant capacity of Medicago minima populations

Kabtni

Sdouga

Rebey

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Hal ini sesuai dengan penelitian yang menunjukkan bahwa alfalfa memiliki efek untuk mengurangi tekanan darah pada tikus percobaan yang dibuat hipertensi (Martinez et al, 2016).…”

Section: Alfalfa (Medicago Sativa L)unclassified

Pola Penggunaan Obat Bahan Alam Sebagai Terapi Komplementer pada Pasien Hipertensi Di Puskesmas

Paramita¹,

Isnuwardana

Nuryanto

et al. 2017

J. Sains Kes.

View full text Add to dashboard Cite

Hypertension is a major health problem throughout the world, including Indonesia. The use of traditional medicine as part of the treatment of hypertension is increasing in the lastKeywords: pattern of drug use, natural medicine, hypertension ABSTRAK Hipertensi merupakan masalah kesehatan utama di seluruh dunia, termasuk Indonesia. Penggunaan obat tradisional sebagai bagian dari pengobatan hipertensi semakin meningkat dalam dekade terakhir. Hal ini disebabkan adanya beberapa faktor, terutama harga obat tradisional yang dianggap lebih murah dengan efek samping yang dianggap lebih sedikit. Penelitian ini mencoba melihat pola penggunaan obat bahan alam sebagai terapi komplementer pada pasien hipertensi di Puskesmas. Penelitian merupakan studi deskriptif yang dilakukan di Puskesmas Sempaja Kota Samarinda pada periode September 2016, dengan mewawancarai 62 pasien hipertensi terkait penggunaan obat bahan alam. Hasil penelitian menunjukkan 70,9% pasien hipertensi di puskesmas juga menggunakan obat bahan alam. Seluruh pasien menggunakan obat bahan alam yang secara teori memang terbukti menurunkan tekanan darah. Namun demikian tidak ada obat bahan alam yang digunakan termasuk obat herbal terstandar atau fitofarmaka. Hanya 15,2% pasien yang menggunakan obat bahan alam yang sesuai dengan peraturan BPOM tentang kriteria jamu. Kesimpulan penelitian ini menunjukkan masih perlunya edukasi penggunaan obat bahan alam di masyarakat untuk penatalaksanaan hipertensi.Kata kunci: pola penggunaan obat, obat bahan alam, hipertensi

show abstract

“…Medicago sativa L., belonging to the family of Leguminosae, is one of the most widely used and distributed homologous plants in the world today (Ma, Li, & Wei, 2016). In the world, M. sativa is widely consumed as an excellent pasture for animals and a nutritious vegetable for humans in the form of salads, tortillas, puddings, soups, and casseroles (Cornara, Xiao, & Burlando, 2016;Martínez et al, 2016). Traditionally, M. sativa has pharmacological effects of improving memory and relieving central nervous system diseases (Bora & Sharma, 2011;Rafinska, Pomastowski, Wrona, Gorecki, & Buszewski, 2016).…”

mentioning

confidence: 99%

A network pharmacology study on the triterpene saponins fromMedicago sativaL. for the treatment of Neurodegenerative diseases

Liu

Huang³

et al. 2019

J Food Biochem

View full text Add to dashboard Cite

Neurodegenerative diseases (NDDs) are characterized by progressive and irreversible, is a kind of complex illnesses, and the long‐term therapy which is frequently associated with adverse side effects. Medicago sativa L., widely consumed as a vegetable, has the effects of improving memory and relieving central nervous system diseases. However, there are less studies on its specific mechanism for NDDs. In this investigation, we applied a method of network pharmacology, which combined molecular docking and network analysis to decipher the mechanisms of M. sativa in NDDs. The pharmacological system generated 55 triterpene saponins from M. sativa, and predicted 27 potential targets with 100 pathways in the treatment of NDDs. As a result, 13 compounds, 10 target proteins, and 6 signaling pathways were found to play important roles in the treatment of NDDs. In addition, in vitro experiments of isolates confirmed activities for NDDs, which were consistent with the results of network pharmacology prediction. Practical applications Medicago sativa L. has been widely consumed as a vegetable, which possesses many nutritional components. As a functional food stuff, M. sativa can improve human health, such as memory improving activities, relieving central nervous system diseases, immunomodulatory, antioxidant, anticancer, and anti‐inflammatory. In this article, the mechanism of triterpene saponins from M. sativa against NDDs was successfully predicted by network pharmacology method. The results will serve as a reference of M. sativa against NDDs.

show abstract

Medicago sativa L., a functional food to relieve hypertension and metabolic disorders in a spontaneously hypertensive rat model

Cited by 19 publications

References 67 publications

Influence of climate variation on phenolic composition and antioxidant capacity of Medicago minima populations

Influence of climate variation on phenolic composition and antioxidant capacity of Medicago minima populations

Pola Penggunaan Obat Bahan Alam Sebagai Terapi Komplementer pada Pasien Hipertensi Di Puskesmas

A network pharmacology study on the triterpene saponins fromMedicago sativaL. for the treatment of Neurodegenerative diseases

Contact Info

Product

Resources

About