Mediation of Systemic Vascular Hyperpermeability in Severe Psoriasis by Circulating Vascular Endothelial Growth Factor

IL-33 augments substance P–induced VEGF secretion from human mast cells and is increased in psoriatic skin

“…VEGF levels are increased in psoriatic plaques compared with normal skin (19,20), especially the VEGF 121 isoform, which causes vascular permeability (22,23). Moreover, the higher VEGF expression correlates with the clinical severity of psoriasis (76,77).…”

“…VEGF is a major proangiogenic factor involved in many inflammatory diseases (21). The VEGF 121 isoform is particularly increased in psoriatic plaques (22) and VEGF is also increased systematically in severe psoriasis (22,23). Genetic studies have shown that several different VEGF polymorphisms are associated with an increased risk of developing psoriasis (24,25).…”

Immunopathogenesis of Psoriasis and Psoriatic Arthritis and Pharmacological Perspectives

“…Cutaneous blood vessels show major abnormalities in psoriatic lesions (94). There is compelling evidence that VEGF expression is increased in lesional psoriatic skin, that the serum levels of VEGF are elevated in patients with severe disease, and that VEGF levels are related with disease activity (58)(59)(60)(61)95). Young et al provided evidence, based on the analysis of polymorphisms of the VEGF gene in psoriatic and healthy individuals, that an "angiogenetic constitution" might determine psoriasis susceptibility (96).…”

Síndrome de extravasamento capilar sistêmico

“…Increased renal vascular permeability is measured in laboratory as proteinuria. 7 There are reports of systemic capillary leak syndrome after the use of acitretin and its cause seems to be increased VEGF both by psoriatic plaque as well as by stimulating the transcription of its gene by etinoic acid.…”

“…Analysis of VEGF, still being studied, might be a useful predictor for clinical outcome and its handling. 7 Different therapeutics such as immunoglobulin IV, theophylline, terbutaline, steroids (our option when the cause is unknown or when psoriasis is associated with acute respiratory distress syndrome or acute pulmonary edema), indomethacin, spironolactone, cyclosporine (our choice when the etiology is unstable psoriasis ), plasmapheresis, prostacyclin, gingko biloba and pentastarch have been tried. Other options under study are: inhibition of apoptosis by anticaspases or antioxidants and inhibitory action on the vascular factor of endothelial growth or on pathways it mediates.…”