Mechanistic Trial Evaluating the Effect of Repetitive Transcranial Magnetic Stimulation on RDoC Constructs in Treatment-Resistant Depression

Cortical Plasticity Mechanism and Efficacy Prediction of Repeated Transcranial Magnetic Stimulation in the Treatment of Depression with Continuous Short Bursts of Rapid Pulse Stimulation (cTBS)

“…From January 2020 to December 2020, 92 elderly mentally ill patients in the city's psychiatric ward were selected and divided into three groups according to random procedures, the “drug treatment group ( n = 31 cases, age (71.03 + 3.99)),” the “low-frequency treatment group ( n = 29 cases, age (70.31 + 4.13)),” and the “high-frequency treatment group ( n = 32 cases, age (69.19 + 3.80)).” Inclusion criteria are as follows: (1) meeting the diagnostic criteria of ICD-10 depression; (2) HAMD-24 scores are all >20; (3) age 60-80, gender not limited; (4) no history of antidepressants, rTMS, MECT, or other physical therapy in the last three months; (5) no serious physical or other mental diseases; (6) early onset depression relapse or late onset depression in old age [ 16 , 17 ].…”