Mechanisms of Prostate Atrophy after Glandular Botulinum Neurotoxin Type A Injection: An Experimental Study in the Rat

Silva, João; Pinto, Rui; Carvallho, Tiago; Coelho, Ana; Avelino, António; Dinis, Paulo; Cruz, Francisco

doi:10.1016/j.eururo.2008.07.003

Cited by 56 publications

(56 citation statements)

References 29 publications

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“…Hyperinsulinemia-associated hyperglycemia is sensed by the ventromedial hypothalamus, which ultimately regulates the sympathetic nervous system [17], and involved in reducing sex hormone-binding globulin, leading to an increase in the estrogen/androgen ratio, a confirmed risk factor of BPH [18]. An animal experiment emphasized the role of the autonomic nervous system in prostatic growth [19]. IGF-1 had been shown to induce hyperplasia in the prostate in a transgenic mouse model that specifically expresses human IGF-1 in prostate epithelial cells [20].…”

Section: Discussionmentioning

confidence: 99%

Impact of Metabolic Syndrome on Benign Prostatic Hyperplasia in Elderly Chinese Men

et al. 2014

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Objective: The aim of the present study was to evaluate the impact of metabolic syndrome (MetS) on benign prostatic hyperplasia (BPH) in elderly Chinese men. Methods: A total of 401 elderly BPH patients were divided into the without or with MetS group to assess the associations of MetS and components of MetS with BPH. Urologic evaluation included prostate volume, International Prostate Symptom Score, serum prostate-specific antigen, duration of concomitant lower urinary tract symptoms (LUTS) and maximum flow rate. Results: Body mass index (BMI), waist circumference, fasting glucose, glycosylated hemoglobin, triglyceride, fasting insulin (FINS), insulin resistance assessed by homeostasis model assessment (HOMA-IR) were greater and high-density lipoprotein cholesterol (HDL-C) was lower in BPH patients with MetS than in those without MetS. The patients with MetS showed a significantly larger prostate volume (p = 0.000) and longer duration of LUTS (p = 0.006) than those without MetS. Prostate volume was positively correlated with BMI (p = 0.000), FINS (p = 0.001), HOMA-IR (p = 0.003) and inversely correlated with HDL-C (p = 0.000). Multiple linear regression analysis showed that prostate volume was significantly correlated with HOMA-IR (p = 0.015). Conclusions: Our results suggest that MetS, BMI, low HDL-C level, increased serum insulin and especially insulin resistance are considered risk factors for prostate enlargement in elderly Chinese men.

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Section: Discussionmentioning

confidence: 99%

Impact of Metabolic Syndrome on Benign Prostatic Hyperplasia in Elderly Chinese Men

et al. 2014

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“…Studies performed in rats (SILVA et al, 2009), dogs (CHUANG et al, 2006 and men (KUO, 2005;BRISINDA et al, 2011) have been developed using BT-A for BPH treatment. However, most of them assessed only the symptomatic and clinical improvement post-treatment, not considering the effects on semen quality.…”

Section: Introductionmentioning

confidence: 99%

Semen parameters and seminal plasma protein and biochemical profiles of dogs with benign prostatic hyperplasia after botulinum toxin type A intraprostatic injection

et al. 2014

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This study aimed to determine the effects of different concentrations of botulinum toxin type A (BT-A) on semen parameters, and seminal plasma biochemical and protein profi les of dogs with benign prostatic hyperplasia (BPH). RESUMO O objetivo do presente estudo foi determinar a ação de diferentes concentrações de toxina botulínica tipo A (TB-A) sobre os parâmetros seminais, perfi s bioquímicos e proteicos do plasma seminal de cães com hiperplasia prostática benigna (HPB). Dezoito cães hígidos, não orquiectomizados com HPB foram divididos em três grupos, os quais foram submetidos à injeção intra-prostática de solução salina (grupo controle -GC), 250UI (GI) ou 500UI (GII) de TB-A. Amostras seminais foram coletadas previamente aos tratamentos e após 2, 4 e 8 semanas. Os parâmetros seminais assim como os valores de pH e concentrações de proteínas totais (TP), cloretos totais (CT), cálcio (Ca), potássio (K), sódio (Na

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“…The cholinergic effect of BoNT-A has been shown to induce generalized atrophy and apoptosis of the glandular epithelium, with a decrease in prostatic growth and secretion. 50,51 The induction of apoptosis by BoNT-A seems to be supported by its adrenergic effects 52,53 and studies indicate that the sympathetic system has a more substantial influence on prostate growth than does the parasympathetic system. 54 Furthermore, published data suggest that the adrenergic blockade inhibits the trophic effects of certain growth factors, such as epidermal growth factor, in the prostate.…”

Section: Mechanism Of Actionmentioning

confidence: 98%

New intraprostatic injectables and prostatic urethral lift for male LUTS

2015

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Treatment modalities for male lower urinary tract symptoms (LUTS) comprise a broad spectrum of medical and surgical options. Interest is growing in minimally invasive treatment options, which should ideally be performed in an outpatient setting and have a short recovery time, durable efficacy and a good safety profile. The preservation of all aspects of sexual function, including antegrade ejaculation, seems to be increasingly important for patients. Initial experimental data on new minimally invasive procedures-such as the intraprostatic injection of novel agents including botulinum neurotoxin A (BoNT-A), NX-1207 and PRX302-were promising, but clinical trials have not confirmed the findings. Trials of the mechanical prostatic urethral lift device-Urolift(®) (Neotract, Inc., USA)-have been positive, but further long-term results are needed to confirm its beneficial effects.

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Mechanisms of Prostate Atrophy after Glandular Botulinum Neurotoxin Type A Injection: An Experimental Study in the Rat

Cited by 56 publications

References 29 publications

Impact of Metabolic Syndrome on Benign Prostatic Hyperplasia in Elderly Chinese Men

Impact of Metabolic Syndrome on Benign Prostatic Hyperplasia in Elderly Chinese Men

Semen parameters and seminal plasma protein and biochemical profiles of dogs with benign prostatic hyperplasia after botulinum toxin type A intraprostatic injection

New intraprostatic injectables and prostatic urethral lift for male LUTS

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