Abstract:The plant kingdom is a rich source of health-promoting compounds and has always played a fundamental role in the isolation, identification, and modification of compounds able to perform several properties on live organisms. Among them, the so-called “antioxidants” have a major potentiality to increase human wellness. Antioxidants are important components in the signaling and defense mechanisms in some plants, where they are precursors of compounds of greater complexity, the modulator of plant growth, and the d… Show more
“…This is largely related to their ability to donate hydrogen atoms, their solubility and chelating properties. In addition to their ability to modulate the activity of the key enzymes mentioned above, phytochemicals contained in plant extracts can also activate or block the transcription of many genes involved in antioxidant defense [29]. The differences in antioxidant activity among the tested samples resulted from different contents of biologically active compounds, which resulted from the use of different extractants during The antioxidant effect of the tested extracts and hydrogels is certainly related to the antioxidant activity of the phytochemicals contained in dogwood fruits.…”
Section: Intracellular Ros Levels In Skin Cellsmentioning
Due to the growing popularity of herbal extract-loaded hydrogels, this study assessed the biological activity of extracts and hydrogels containing three types (water (WE), water–ethanol (EE) and water–glycerin (GE)) of Cornus mas L. (dogwood) extracts. The content of biologically active compounds in the extracts was assessed using the UPLC-DAD-MS technique. Antioxidant properties were assessed by using DPPH and ABTS radicals and measuring the intracellular level of reactive oxygen species. Alamar Blue and Neutral Red tests were used to measure the cytotoxicity of the tested samples on skin cells—fibroblasts and keratinocytes. Cell migration and the anti-aging activity of the tested extracts and hydrogels were assessed. Transepidermal water loss and skin hydration after applying the hydrogels to the skin were also determined. A chromatographic analysis revealed that the extracts contained polyphenols, including gallic, caftaric, protocatechuic, chlorogenic, ellagic and p-coumaroylquinic acids, as well as iridoids, with loganic acid as the predominant component. Additionally, they contained cyanidin 3-O-galactoside, pelargonidin 3-O-glucoside and quinic acid. The obtained results show that the tested extracts and hydrogels had strong antioxidant properties and had a positive effect on the viability of skin cells in vitro. Additionally, it was shown that they stimulated the migration of these cells and had the ability to inhibit the activity of collagenase and elastase. Moreover, the tested hydrogels increased skin hydration and prevented transepidermal water loss. The obtained results indicate that the developed hydrogels may be effective delivery systems for phytochemicals contained in dogwood extracts.
“…This is largely related to their ability to donate hydrogen atoms, their solubility and chelating properties. In addition to their ability to modulate the activity of the key enzymes mentioned above, phytochemicals contained in plant extracts can also activate or block the transcription of many genes involved in antioxidant defense [29]. The differences in antioxidant activity among the tested samples resulted from different contents of biologically active compounds, which resulted from the use of different extractants during The antioxidant effect of the tested extracts and hydrogels is certainly related to the antioxidant activity of the phytochemicals contained in dogwood fruits.…”
Section: Intracellular Ros Levels In Skin Cellsmentioning
Due to the growing popularity of herbal extract-loaded hydrogels, this study assessed the biological activity of extracts and hydrogels containing three types (water (WE), water–ethanol (EE) and water–glycerin (GE)) of Cornus mas L. (dogwood) extracts. The content of biologically active compounds in the extracts was assessed using the UPLC-DAD-MS technique. Antioxidant properties were assessed by using DPPH and ABTS radicals and measuring the intracellular level of reactive oxygen species. Alamar Blue and Neutral Red tests were used to measure the cytotoxicity of the tested samples on skin cells—fibroblasts and keratinocytes. Cell migration and the anti-aging activity of the tested extracts and hydrogels were assessed. Transepidermal water loss and skin hydration after applying the hydrogels to the skin were also determined. A chromatographic analysis revealed that the extracts contained polyphenols, including gallic, caftaric, protocatechuic, chlorogenic, ellagic and p-coumaroylquinic acids, as well as iridoids, with loganic acid as the predominant component. Additionally, they contained cyanidin 3-O-galactoside, pelargonidin 3-O-glucoside and quinic acid. The obtained results show that the tested extracts and hydrogels had strong antioxidant properties and had a positive effect on the viability of skin cells in vitro. Additionally, it was shown that they stimulated the migration of these cells and had the ability to inhibit the activity of collagenase and elastase. Moreover, the tested hydrogels increased skin hydration and prevented transepidermal water loss. The obtained results indicate that the developed hydrogels may be effective delivery systems for phytochemicals contained in dogwood extracts.
“…Supplementation of exogenous antioxidants or increasing endogenous antioxidant defenses of the body is a promising way of fighting the undesirable effects of reactive oxygen species (ROS) induced oxidative damage [ 33 ]. The plant kingdom is a rich source of health-promoting compounds especially as natural antioxidants [ 34 ]. Several studies have accentuated on the high antioxidant capacity of plants, their derivatives such as EOs and isolated compounds in the recent years, thus highlighting their usefulness in pharmaceutical, cosmetics, food and beverage industries, especially as some synthetic antioxidants such as BHA and BHT are now suspected to be potentially harmful to human health [ 35 , 36 , 37 , 38 , 39 ].…”
In this study, the essential oils (EOs) obtained from three endemic Prangos species from Turkey (P. heyniae, P. meliocarpoides var. meliocarpoides, and P. uechtritzii) were studied for their chemical composition and biological activities. β-Bisabolenal (12.2%) and caryophyllene oxide (7.9%) were the principal components of P. heyniae EO, while P. meliocarpoides EO contained sabinene (16.7%) and p-cymene (13.2%), and P. uechtritzii EO contained p-cymene (24.6%) and caryophyllene oxide (19.6%), as the most abundant components. With regard to their antioxidant activity, all the EOs were found to possess free radical scavenging potential demonstrated in both DPPH and ABTS assays (0.43–1.74 mg TE/g and 24.18–92.99 mg TE/g, respectively). Additionally, while no inhibitory activity was displayed by P. meliocarpoides and P. uechtritzii EOs against both cholinesterases (acetyl- and butyryl-cholinesterases). Moreover, all the EOs were found to act as inhibitors of tyrosinase (46.34–69.56 mg KAE/g). Molecular docking revealed elemol and α-bisabolol to have the most effective binding affinity with tyrosinase and amylase. Altogether, this study unveiled some interesting biological activities of these EOs, especially as natural antioxidants and tyrosinase inhibitors and hence offers stimulating prospects of them in the development of anti-hyperpigmentation topical formulations.
“…The Chlorogenic acid content was significantly reduced in the treatment group; moreover, a number of metabolites with the capacities of ROS scavenging, namely 4-hydroxybenzoate, 3-hydroxybenzoic acid, 3, 4-dihydroxyhydrocinnamic acid, salicylic acid, hydroquinone, noradrenaline, 1, 2, 3-trihydroxybenzene, 1, 2, 4-benzenetriol were decreased by 16–49% in response to the Fe 3 O 4 NPs compared with the control ( Figure 5 ). On the one hand, these substances are consumed as reducing agents, acting as hydrogen donors to inhibit or quench a free radical ( 60 ). Given the large amounts of ferric and ferrous iron available on the surface of Fe 3 O 4 NPs, they exhibit peroxidase-like activity because of their ability to catalyze the oxidation of peroxidase substrates ( 61 ).…”
It is found that the growth of Dendrobium huoshanense was dependent on Fe3O4, while the bioavailability of plants to ordinary Fe3O4 was low on the earth. In order to improve the growth, quality and yield of D. huoshanense, we used Fe3O4 NPs (100 or 200 mg/L) that was easily absorbed by plants as nano-fertilizer to hydroponically treat seedlings of D. huoshanense for 3 weeks. Fe3O4 NPs induced not only earlier flowering and increased sugar content and photosynthesis, but also stressed to plants, increased MDA content and related antioxidant enzymes activities. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) revealed that Fe3O4 NPs caused a significant accumulation of Fe and some other nutrient elements (Mn, Co, B, Mo) in stems of D. huoshanense. Metabolomics revealed that the metabolites were reprogrammed in D. huoshanense when under Fe3O4 NPs exposure. Fe3O4 NPs inhibited antioxidant defense-related pathways, demonstrating that Fe3O4 NPs have antioxidant capacity to protect D. huoshanense from damage. As the first study associating Fe3O4 NPs with the quality of D. huoshanense, it provided vital insights into the molecular mechanisms of how D. huoshanense responds to Fe3O4 NPs, ensuring the reasonable use of Fe3O4 NPs as nano-fertilizer.
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