Mechanisms of Co, Ni, and Mn toxicity: From exposure and homeostasis to their interactions with and impact on lipids and biomembranes

Sule, Kevin; Umbsaar, Jenelle; Prenner, Elmar J.

doi:10.1016/j.bbamem.2020.183250

Cited by 67 publications

(43 citation statements)

References 147 publications

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“…Ni toxicity reduced the intake of CO 2 , declined photosynthesis, chlorophyll contents, and relative water [ 9 ], and impaired cell division and elongation [ 10 ]. Consequently, the initiation of oxidative damage annoys the balance between antioxidants and reactive oxygen species (ROS) [ 11 ], damaging the nucleic acids, proteins, and organelles’ membranes [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Phytoremediation of nickel by quinoa: Morphological and physiological response

et al. 2022

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The amount of soil contaminated with heavy metal increases due to urbanization, industrialization, and anthropogenic activities. Quinoa is considered a useful candidate in the remediation of such soil. In this pot experiment, the phytoextraction capacity of quinoa lines (A1, A2, A7, and A9) against different nickel (Ni) concentrations (0, 50, and 100 mg kg-1) were investigated. Required Ni concentrations were developed in polythene bags filled with sandy loam soil using nickel nitrate salt prior to two months of sowing and kept sealed up to sowing. Results showed that translocation of Ni increased from roots to shoots with an increase in soil Ni concentration in all lines. A2 line accumulated high Ni in leaf compared to the root as depicted by translocation factor 3.09 and 3.21 when grown at soil having 50 and 100 Ni mg kg-1, respectively. While, in the case of root, A7 accumulated high Ni followed by A9, A1, and A2, respectively. There was a 5–7% increased seed yield by 50 mg kg-1 Ni in all except A1 compared to control. However, growth and yield declined with a further increase in Ni level. The maximum reduction in yield was noticed in A9, which was strongly linked with poor physiological performance, e.g., chlorophyll a, b, and phenolic contents. Ni concentrations in the seed of all lines were within the permissible value set (67 ppm) by FAO/WHO. The result of the present study suggests that quinoa is a better accumulator of Ni. This species can provide the scope of decontamination of heavy metal polluted soil. The screened line can be used for future quinoa breeding programs for bioremediation and phytoextraction purpose.

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Section: Introductionmentioning

confidence: 99%

Phytoremediation of nickel by quinoa: Morphological and physiological response

et al. 2022

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“…Exposure to Mn, Ni, Cr, and Co has increased because of their use as industrial metals in commercial applications over the last century. A recent study summarized that the main detrimental health impact of Mn, Ni, and Co, to a lesser extent, was on lipid peroxidation arising from oxidative stress [35]. Cr had multiple oxidation states ranging from −2 to + 6, in which the trivalent and hexavalent forms were primarily stable structures.…”

Section: Discussionmentioning

confidence: 99%

Occupational Exposure to Metals and Serum Adiponectin Levels Among Shipyard Workers: A Cohort Study with Weighted Quantile Sum Regression Analyses

Chen

et al. 2021

Preprint

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Background: The influence of welding-associated air pollutants on workers’ health is mainly regarded as a core issue in public health and occupational medicine. Previous studies have indicated that workers exposed to metal fumes had an increased risk of metabolic syndrome, which was correlated with decreased serum adiponectin levels. This study aimed to explore whether heavy metal exposure affects the concentration of adiponectin among welding workers. Methods: The study participants were recruited from a shipyard with 31 office workers and 100 welding workers in 2015. Urinary metal concentrations were measured by inductively coupled plasma–mass spectrometry. Serum adiponectin was measured by enzyme-linked immunosorbent assay. Inferential statistics on repeated measures were performed using generalized estimating equations (GEEs). A weighted quantile sum (WQS) regression model was conducted to examine the joint effect of the association of multimetal exposure with serum adiponectin. Results: After adjustment for all confounding variables through a GEE analysis, significantly negative associations of numerous urinary metals with serum adiponectin were detected in the welding workers, including Cr (β = -0.088; 95% CI: -0.148, -0.027), Mn (β = -0.174; 95% CI: -0.267, -0.081), Co (β = -0.094; 95% CI: -0.158, -0.029), Ni (β = -0.108; 95% CI: -0.208, -0.008), Cd (β = -0.067; 95% CI: -0.115, -0.018), and Pb (β = -0.089; 95% CI: -0.163, -0.015). The contributions of multiple urinary metal levels to serum adiponectin levels, determined individually by WQS regression, suggested that Pb was the greatest contributor. Conclusions: Welding workers exposed to heavy metals such as Pb, Cr, Co, Mn, Ni, and Cd might have reduced serum adiponectin levels and an increased risk of cardiovascular disease.

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“…Nickel is the 24 th most prevalent metal in the Earth's crust, with roughly 50 parts per million (Sule et al 2020). Nickel's oxidation state is commonly Ni 2+ ; however, it may take on any of the states from 1 to 4.…”

Section: Introductionmentioning

confidence: 99%

Protection by amino acids against certain metal ion-induced toxicity in Spirulina platensis

Vijayarti¹,

Agarwal

Sah

et al. 2022

Preprint

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Numerous health issues, such as allergy, cardiovascular, renal, lung, and nose cancers, among others, may be brought on by nickel (Ni) exposure. However, mitochondrial dysfunction and oxidative stress are frequently linked to nickel ions even though the molecular mechanism(s) of nickel-induced toxicity is poorly understood. Arthrospira (Spirulina) platensis is a reliable source of high-quality nutritive proteins for man as well as domestic animals. The present research work demonstrates a significant defensive effect of amino acids like methionine, glutathione and ascorbic acid against the abiotic metabolic stress induced by heavy metals. The changes in biomass, carbohydrate, protein, pigmentation (chlorophyll-a), antioxidant potential, and nitric oxide radical scavenging potential have been investigated in metabolic stressed Spirulina platensis. Our experimental results showed that the growth hampered by doses of nickel and silver was overcome in the presence of amino acids. The effect was significantly attenuated when the culture medium was supplemented with 10 µg/ml amino acids (namely, methionine, glutathione, and ascorbic acid). Further, metabolically stressed S. platensis cultures supplemented with amino acids not only boosted biomass but also phycocyanin that to exhibit a variety of pharmacological properties. The supplementation with the amino acids showed insignificant protection against Ni-induced toxicity.

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Mechanisms of Co, Ni, and Mn toxicity: From exposure and homeostasis to their interactions with and impact on lipids and biomembranes

Cited by 67 publications

References 147 publications

Phytoremediation of nickel by quinoa: Morphological and physiological response

Phytoremediation of nickel by quinoa: Morphological and physiological response

Occupational Exposure to Metals and Serum Adiponectin Levels Among Shipyard Workers: A Cohort Study with Weighted Quantile Sum Regression Analyses

Protection by amino acids against certain metal ion-induced toxicity in Spirulina platensis

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