Numerous health issues, such as allergy, cardiovascular, renal, lung, and nose cancers, among others, may be brought on by nickel (Ni) exposure. However, mitochondrial dysfunction and oxidative stress are frequently linked to nickel ions even though the molecular mechanism(s) of nickel-induced toxicity is poorly understood. Arthrospira (Spirulina) platensis is a reliable source of high-quality nutritive proteins for man as well as domestic animals. The present research work demonstrates a significant defensive effect of amino acids like methionine, glutathione and ascorbic acid against the abiotic metabolic stress induced by heavy metals. The changes in biomass, carbohydrate, protein, pigmentation (chlorophyll-a), antioxidant potential, and nitric oxide radical scavenging potential have been investigated in metabolic stressed Spirulina platensis. Our experimental results showed that the growth hampered by doses of nickel and silver was overcome in the presence of amino acids. The effect was significantly attenuated when the culture medium was supplemented with 10 µg/ml amino acids (namely, methionine, glutathione, and ascorbic acid). Further, metabolically stressed S. platensis cultures supplemented with amino acids not only boosted biomass but also phycocyanin that to exhibit a variety of pharmacological properties. The supplementation with the amino acids showed insignificant protection against Ni-induced toxicity.
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