Mechanisms by which cyclodextrins modify drug release from polymeric drug delivery systems

Bibby, David C.; Davies, Nigel; Tucker, Ian G.

doi:10.1016/s0378-5173(00)00335-5

Cited by 271 publications

(102 citation statements)

References 55 publications

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“…So, it is clear that the polymer β-cyclodextrin in higher amount used in precipitation method can give very much better dissolution rate. It was verified that the presence of β-cyclodextrin into polymeric drug delivery systems can also influence the drug release mechanism by Bibby et al (Bibby et al, 2000). In the present study, the results evidenced that release profiles of these formulations were only slightly slower than those containing glyceryl monosterate.…”

Section: Discussionsupporting

confidence: 82%

Dissolution enhancement of glimepiride dispersion using glyceryl monostearate and ?-cyclodextrin as carrier

Rafshanjani

Rahman

Parvin³

et al. 2015

Int Curr Pharm J

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Glimepiride is an antidiabetic drug of sulfonylurea group and indicated for the treatment of type 2 diabetes mellitus. The present study was conducted to enhance the dissolution rate of glimepiride solid lipid nano particle dispersions using hot homogenization method and glimepiride solid dispersion by precipitation method. Solid lipid nanoparticles have been used as suitable carriers for delivery of drug with poor solubility. In this investigation glyceryl monostearate and stearic acid were used as solid lipid, Lutrol F-68 as surfactant, Tween 80 as stabilizer and the used polymer were urea crystal and ?-cyclodextrin. Three formulations were prepared in different ratios for two methods and were designated as GMLN1 to GMLN3 in case of hot homogenization method and GMP1 to GMP3 for precipitation method. The evaluation of all the dispersions were done by in vitro dissolution studies using US Pharmacopeia type II apparatus (paddle method) in 900ml distilled water at 50 rpm to a temperature of 37°C ± 0.5°C for 45 minutes. In situ and externally sink method revealed the release pattern of drug was found to follow zero order, first order and Korsmeyer-Peppas equations. Improved dissolution profile was observed in all the solid lipid nano particle dispersions as compared to pure drug as well as market preparation. Thus, glyceryl monostearate and ?-cyclodextrin can be successfully used as carrier for improvement of dissolution and bioavailability of glimepiride.Rafshanjani et al., International Current Pharmaceutical Journal, September 2015, 4(10): 436-441

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Section: Discussionsupporting

confidence: 82%

Dissolution enhancement of glimepiride dispersion using glyceryl monostearate and ?-cyclodextrin as carrier

Rafshanjani

Rahman

Parvin³

et al. 2015

Int Curr Pharm J

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“…As we mentioned before, this situation might be related with the existence of HP␤CD in the matrix [51]. CDs have ability to enhance drug release from polymeric systems, since they increase the concentration of diffusible species within the matrix [52]. When a hydrophobic drug makes complex with CD its solubility increases considerably where CD-IC is usually more hydrophilic than the free drug.…”

Section: In Vitro Release Studymentioning

confidence: 98%

Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system

Aytaç

Sen

Durgun

et al. 2015

Colloids and Surfaces B: Biointerfaces

105

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a b s t r a c tHerein, hydroxypropyl-beta-cyclodextrin (HP␤CD) inclusion complex (IC) of a hydrophobic drug, sulfisoxazole (SFS) was incorporated in hydroxypropyl cellulose (HPC) nanofibers (HPC/SFS/HP␤CD-IC-NF) via electrospinning. SFS/HP␤CD-IC was characterized by DSC to investigate the formation of inclusion complex and the stoichiometry of the complex was determined by Job's plot. Modeling studies were also performed on SFS/HP␤CD-IC using ab initio technique. SEM images depicted the defect free uniform fibers and confirmed the incorporation of SFS/HP␤CD-IC in nanofibers did not alter the fiber morphology. XRD analyses showed amorphous distribution of SFS/HP␤CD-IC in the fiber mat. Release studies were performed in phosphate buffered saline (PBS). The results suggest higher amount of SFS released from HPC/SFS/HP␤CD-IC-NF when compared to free SFS containing HPC nanofibers (HPC/SFS-NF). This was attributed to the increased solubility of SFS by inclusion complexation. Sandwich configurations were prepared by placing HPC/SFS/HP␤CD-IC-NF between electrospun PCL nanofibrous mat (PCL-HPC/SFS/HP␤CD-IC-NF). Consequently, PCL-HPC/SFS/HP␤CD-IC-NF exhibited slower release of SFS as compared with HPC/SFS/HP␤CD-IC-NF. This study may provide more efficient future strategies for developing delivery systems of hydrophobic drugs.

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“…Several possibilities of enhanced drug release have been described in the literature (90,91). The main suggested mechanisms include: an increased surface area of the drug available for release, increased aqueous solubility of the drug and/or improved wettability of drug particles (17,79,92).…”

Section: Mechanism Of Enhanced Drug Release From Liquisolid Systemsmentioning

confidence: 99%

Liquisolid systems and aspects influencing their research and development

Vraníková¹,

Gajdziok²

2013

Acta Pharmaceutica

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Mechanisms by which cyclodextrins modify drug release from polymeric drug delivery systems

Cited by 271 publications

References 55 publications

Dissolution enhancement of glimepiride dispersion using glyceryl monostearate and ?-cyclodextrin as carrier

Dissolution enhancement of glimepiride dispersion using glyceryl monostearate and ?-cyclodextrin as carrier

Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system

Liquisolid systems and aspects influencing their research and development

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