Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system

Abstract

a b s t r a c tHerein, hydroxypropyl-beta-cyclodextrin (HP␤CD) inclusion complex (IC) of a hydrophobic drug, sulfisoxazole (SFS) was incorporated in hydroxypropyl cellulose (HPC) nanofibers (HPC/SFS/HP␤CD-IC-NF) via electrospinning. SFS/HP␤CD-IC was characterized by DSC to investigate the formation of inclusion complex and the stoichiometry of the complex was determined by Job's plot. Modeling studies were also performed on SFS/HP␤CD-IC using ab initio technique. SEM images depicted the defect free uniform fibers and confirmed the incorporation of SFS/HP␤CD-IC in nanofibers did not alter the fiber morphology. XRD analyses showed amorphous distribution of SFS/HP␤CD-IC in the fiber mat. Release studies were performed in phosphate buffered saline (PBS). The results suggest higher amount of SFS released from HPC/SFS/HP␤CD-IC-NF when compared to free SFS containing HPC nanofibers (HPC/SFS-NF). This was attributed to the increased solubility of SFS by inclusion complexation. Sandwich configurations were prepared by placing HPC/SFS/HP␤CD-IC-NF between electrospun PCL nanofibrous mat (PCL-HPC/SFS/HP␤CD-IC-NF). Consequently, PCL-HPC/SFS/HP␤CD-IC-NF exhibited slower release of SFS as compared with HPC/SFS/HP␤CD-IC-NF. This study may provide more efficient future strategies for developing delivery systems of hydrophobic drugs.

Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility

“…Incorporation of QU/b-CD-IC into electrospun nanofibres could be a valuable approach to use QU in a more efficient way, because of the high surface area-tovolume ratio and highly porous structure of nanofibres. Related studies on CD-IC incorporated electrospun nanofibres for different purposes have already been reported by our group (Aytac, Dogan, Tekinay, & Uyar, 2014;Aytac, Sen, Durgun, & Uyar, 2015;Canbolat, Celebioglu, & Uyar, 2014;Celebioglu, Umu, Tekinay, & Uyar, 2014;Kayaci, Ertas, & Uyar, 2013;Kayaci, Sen, Durgun, & Uyar, 2014;Kayaci, Umu, Tekinay, & Uyar, 2013;Kayaci & Uyar, 2012). CDs were also used for crosslinking of polymeric materials (Li & Hsieh, 2005;Liu, Zhang, Liu, Ni, & Li, 2013).…”

Electrospinning of cyclodextrin/linalool-inclusion complex nanofibers: Fast-dissolving nanofibrous web with prolonged release and antibacterial activity

“…In addition, CDs have distinct advantages over many molecules, since they can form host-guest ICs with a variety of compounds. The production of CD-IC incorporated polymeric nanofibers has been previously reported by our group (Aytac, Dogan, Tekinay, & Uyar, 2014;Aytac, Kusku, Durgun, & Uyar, 2016a,b;Aytac, Sen, Durgun, & Uyar, 2015;Kayaci, Sen, Durgun, & Uyar, 2014;Kayaci & Uyar, 2012;Uyar, Nur, Hacaloglu, & Besenbacher, 2009. However, organic solvents have been used in most of these studies in order to dissolve the polymeric matrix for the preparation of solution for electrospinning.…”

Encapsulation of gallic acid/cyclodextrin inclusion complex in electrospun polylactic acid nanofibers: Release behavior and antioxidant activity of gallic acid

“…Polylactic acid (PLA) is a biodegradable aliphatic polyester produced from L-lactic acid and well suited for food packaging and drug delivery applications owing to its biocompatibility, biodegradability; carbon dioxide, oxygen and water permeability, and light barrier properties [19]. Leading studies related to incorporation of CD-IC of various guest molecules into electrospun nanofibers were reported by our research group [18,[20][21][22][23][24][25][26][27][28].…”

“…The release of SFS was much more but slower from HPC/SFS/CD-IC-NF as compared to HPC/SFS/CD-IC-film. Low surface area of HPC/SFS/CD-IC-film and close location of SFS to the surface in HPC/SFS/CD-IC-film was stated the reason of less amount and quick release of SFS from HPC/SFS/CD-IC-film [18]. Polylactic acid (PLA) is a biodegradable aliphatic polyester produced from L-lactic acid and well suited for food packaging and drug delivery applications owing to its biocompatibility, biodegradability; carbon dioxide, oxygen and water permeability, and light barrier properties [19].…”