2000
DOI: 10.1016/s0024-3205(00)00590-7
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Mechanism of mifepristone-induced spasmolytic effect on isolated rat uterus

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Cited by 7 publications
(8 citation statements)
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“…The effect of RU-486 is unlikely to be a direct action on contractile proteins, because RU-486 is a progesterone nuclear receptor antagonist (19). In contrast to contraction, RU-486 actually relaxed KCl-induced contraction of rat nonpregnant uterine smooth muscle in vitro (38). In the present study, the in vitro persistent increase in contractility caused by in vivo administration of RU-486 could be a consequence of progesterone-related signal transduction or an indirect consequence resulting from labor commencing.…”
Section: Discussionmentioning
confidence: 93%
“…The effect of RU-486 is unlikely to be a direct action on contractile proteins, because RU-486 is a progesterone nuclear receptor antagonist (19). In contrast to contraction, RU-486 actually relaxed KCl-induced contraction of rat nonpregnant uterine smooth muscle in vitro (38). In the present study, the in vitro persistent increase in contractility caused by in vivo administration of RU-486 could be a consequence of progesterone-related signal transduction or an indirect consequence resulting from labor commencing.…”
Section: Discussionmentioning
confidence: 93%
“…The nongenomic effects are rapid in onset and not modified by inhibitors of protein synthesis. 13,[39][40][41] Several studies (Table 1) in a variety of species, including human, have demonstrated the nongenomic effects of steroids in vitro including the modification of myocardial contractility, [52][53][54] smooth muscle contractility, 14,37,40,50,[55][56][57][58][59][60][61][62] and membrane excitability of nerve cells. 39,41,63 Concerning mifepristone, some studies have demonstrated that it decreased uterine contractility.…”
Section: Nongenomic Pathways Of Mifepristonementioning
confidence: 99%
“…9,11 Besides this action, mifepristone also can induce rapid (seconds to minutes) nongenomic effects, which are not due to changes in gene expression or protein synthesis. [12][13][14] The nongenomic effects of mifepristone are independent of the activation of classical PR. A membrane receptor can be involved and different mechanisms have been pointed to explain this effect.…”
Section: Introductionmentioning
confidence: 99%
“…Compounds 1 -13 were tested for the contraction of uterus rings using the following protocol: The uterus rings were contracted with depolarizing solution, and the test substances were added upon tonic contraction 20 min after stimulus; this time corresponds approximately to a plateau phase of methods previously used (Parra et al, 2000;Revuelta et al, 2000;Shimizu et al, 2000). The tested concentrations for all the compounds were 30, 10, and 3 μg/mL and were dissolved in an ethanol/DMSO (2:1) mixture in such a way that the fi nal vehicle content in the organ bath was 0.15%, demonstrating the innocuity.…”
Section: Methodsmentioning
confidence: 99%