Mechanism of apatite formation on a poorly crystallized calcium phosphate in a simulated body fluid (SBF) at 37 °C

Dridi, Atef; Riahi, Khira Zlaoui; Somrani, Sayda

doi:10.1016/j.jpcs.2021.110122

Cited by 41 publications

(17 citation statements)

References 57 publications

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“…The EDX results showed that the Ca/P atomic ratio of the precipitate (0.5) on the debonded brackets was much lower than that of hydroxyapatite (1.67). This may suggest that the precipitate could be representative of the early stage of calcium phosphate crystal formation because the immersion time of the specimen was only 24 h. The Ca/P ratio may be increased with an increase in the immersion time 54 . A previous study demonstrated that the precipitation of hydroxyapatite could be detected on an orthodontic adhesive containing bioactive glass after immersion in artificial saliva for 6 months 55 .…”

Section: Discussionmentioning

confidence: 99%

Physical/mechanical and antibacterial properties of orthodontic adhesives containing Sr-bioactive glass nanoparticles, calcium phosphate, and andrographolide

Chaichana

Insee

Chanachai

et al. 2022

Sci Rep

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White spot lesions around orthodontic brackets are the major complication during fixed orthodontic treatment. This study prepared orthodontic adhesives for promoting mineral precipitation and reducing bacterial growth. Adhesives with added calcium phosphate monohydrate/Sr-bioactive glass nanoparticles (Sr/CaP) and andrographolide were prepared. The physical/mechanical and antibacterial properties of the adhesives were tested. The additives reduced the monomer conversion of the materials (62 to 47%). The addition of Sr/CaP and andrographolide increased the water sorption (from 23 to 46 μg/mm3) and water solubility (from 0.2 to 5.9 μg/mm3) but reduced the biaxial flexural strength (from 193 to 119 MPa) of the adhesives. The enamel bond strengths of the experimental adhesives (19–34 MPa) were comparable to that of the commercial material (p > 0.05). The Sr/CaP fillers promoted Ca, Sr, and P ion release and the precipitation of calcium phosphate at the debonded interface. An increase in the Sr/CaP concentration enhanced the inhibition of S. mutans by 18%, while the effect of andrographolide was not detected. The abilities of the adhesives to promote ion release, calcium phosphate precipitation, and the growth inhibition of cariogenic bacteria were expected to reduce the occurrence of white spot lesions. The additives reduced the physical/mechanical properties of the materials, but the corresponding values were within the acceptable range.

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Section: Discussionmentioning

confidence: 99%

Physical/mechanical and antibacterial properties of orthodontic adhesives containing Sr-bioactive glass nanoparticles, calcium phosphate, and andrographolide

Chaichana

Insee

Chanachai

et al. 2022

Sci Rep

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“…For all the samples, the formation of an inhomogeneous mineral layer is clearly observed, re ected by the irregular distribution of aggregates of nanocrystals on the surface, the size and density of which are dependent on the incubation time and the composition of the scaffold. Several authors have observed similar results 73,74,75,76,77,78 .…”

Section: Mineralization Assaysmentioning

confidence: 54%

3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering

N’Gatta

Belaid

Assanvo

et al. 2022

Preprint

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Cellulose nanocrystals (CNC) are drawing increasing attention in the fields of biomedicine and healthcare owing to their durability, biocompatibility, biodegradability and excellent mechanical properties. Herein, we fabricated using fused deposition modelling (FDM) technology 3D composite scaffolds from polylactic acid (PLA) and CNC extracted from Ficus thonningii (FT). Scanning electron microscopy revealed that the printed scaffolds exhibit interconnected pores with an estimated average pore size of approximately 400 µm. Incorporating 3% (w/w) of CNC into the composite improved PLA mechanical properties (Young's modulus increased by ~ 30%) and wettability (water contact angle decreased by ~ 17%). The mineralization process of printed scaffolds using simulated body fluid was validated and nucleation of hydroxyapatite confirmed. Additionally, cytocompatibility tests revealed that PLA and PLA/CNC scaffolds are non-toxic and compatible with bone cells. Our design, based on rapid 3D printing of PLA/CNC composites, combines the ability to control the architecture and provide improved mechanical and biological properties of the scaffolds, which opens perspectives for applications in bone tissue engineering and in regenerative medicine.

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“…Then, 25 μL of silver diamine nitrate (SDN) solution (48% SDN; Dentalife, Victoria, Australia), SDF (38% SDF, Topamine TM ; Dentalife, Victoria, Australia), or deionized water (control group) was applied to specimens from each tooth ( n = 7/group) for 30 s. The specimens were then cleaned with water from a triple syringe for 10 s, and immersed in simulated body fluid (SBF; BS ISO 23317:2014) ( Table 1 ) [ 29 ]. SBF contains the same phosphate concentration as blood plasma or body fluid (pH = 7.40) ( Table 2 ) [ 30 , 31 ]. SBF was expected to mimic the environment where the solution was adsorbed into the dentin and exposed to dentinal fluid.…”

Section: Methodsmentioning

confidence: 99%

Effects of Silver Diamine Nitrate and Silver Diamine Fluoride on Dentin Remineralization and Cytotoxicity to Dental Pulp Cells: An In Vitro Study

Srisomboon

Kettratad

Pakawanit

et al. 2022

JFB

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Silver diamine nitrate (SDN) is expected to help control caries similar to silver diamine fluoride (SDF). The aim of this study was to determine the mineral precipitation in demineralized dentin and the cytotoxicity of SDN and SDF to dental pulp cells. Demineralized dentin specimens were prepared, and SDF, SDN, or water (control) was applied. The specimens were then remineralized in simulated body fluid for 2 weeks. The mineral precipitation in the specimens was examined using FTIR-ATR, SEM-EDX, and synchrotron radiation X-ray tomographic microscopy (SRXTM). Additionally, the cytotoxicity of SDF and SDN to human dental pulp stem cells was analyzed using an MTT assay. The increase in FTIR spectra attributable to apatite formation in demineralized dentin in the SDF group was significantly higher compared to the SDN and control groups (p < 0.05). Dentinal tubule occlusion by the precipitation of silver salts was detected in both SDF and SDN groups. The mineral density as shown in SRXTM images and cytotoxicity of both SDN and SDF groups were comparable (p > 0.05). In conclusion, SDF demonstrated superior in vitro apatite formation compared to SDN. However, the degree of mineral precipitation and cytotoxic effects of both were similar.

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Mechanism of apatite formation on a poorly crystallized calcium phosphate in a simulated body fluid (SBF) at 37 °C

Cited by 41 publications

References 57 publications

Physical/mechanical and antibacterial properties of orthodontic adhesives containing Sr-bioactive glass nanoparticles, calcium phosphate, and andrographolide

Physical/mechanical and antibacterial properties of orthodontic adhesives containing Sr-bioactive glass nanoparticles, calcium phosphate, and andrographolide

3D printing of cellulose nanocrystals based composites to build robust biomimetic scaffolds for bone tissue engineering

Effects of Silver Diamine Nitrate and Silver Diamine Fluoride on Dentin Remineralization and Cytotoxicity to Dental Pulp Cells: An In Vitro Study

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