Mechanism of anti-hyperglycemic action of Vatairea macrocarpa (Leguminosae): Investigation in peripheral tissues

Baviloni, Paula Domingues; Santos, Maísa Pavani dos; Aiko, Gustavo Mitsuo; Reis, Silvia Regina de Lima; Latorraca, Márcia Queiroz; Silva, Virgínia Cláudia da; Dall’Oglio, Evandro Luiz; Júnior, Paulo Teixeira de Sousa; Lopes, Carbene França; Baviera, Amanda Martins; Kawashita, Nair Honda

doi:10.1016/j.jep.2010.06.015

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…glibenclamide. Baviloni et al 19 showed antihyperglycemic activity of stem-bark extract of Vatairea macrocarpa in the treatment of diabetic rats. Umar et al 20 observed that Tetracera scandens had antidiabetic efficacy in diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of Passiflora edulis on the Metabolic Profile of Diabetic Wistar Rat Offspring

Barbalho

Damasceno

Spada

et al. 2011

Journal of Medicinal Food

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Dry extract of the genus Passiflora has been shown to help control glycemia and lipid levels. The objective of this study was to evaluate the effects of passion fruit (P. edulis) on the biochemical profile of offspring from diabetic rats. Diabetes was induced by streptozotocin. The diabetes group consisted of 10 rats with glucose levels greater than 200 mg/dL; the nondiabetic (control) group consisted of 10 rats with glucose levels less than 120 mg/dL. After the diagnosis of diabetes, the mating phase was started. By day 21 of pregnancy, the offspring were born; the dams were kept in individual cages with their offspring until the weaning period. The offspring were then divided into 4 groups (n = 15 each): G1 were offspring from control dams, G2 were offspring from treated nondiabetic dams, G3 were offspring from diabetic dams, and G4 were offspring from treated diabetic dams. For 30 consecutive days, G1 and G3 offspring were treated with vehicle (oral gavage) and G2 and G4 offspring were treated with passion fruit juice (oral gavage). After 30-day treatment, the animals were anesthetized and killed, and blood was drawn immediately for analysis of the biochemical profile (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and glucose). The G2 and G4 rats showed significantly reduced total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels and an increased high-density lipoprotein cholesterol level. The use of passion fruit juice improved lipid profiles, suggesting that this plant may have beneficial effects in the prevention and treatment of dyslipidemias and hyperglycemia.

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Section: Discussionmentioning

confidence: 99%

Effects of Passiflora edulis on the Metabolic Profile of Diabetic Wistar Rat Offspring

Barbalho

Damasceno

Spada

et al. 2011

Journal of Medicinal Food

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“…Many other authors have reported the beneficial effects of plants on glycemic and lipid profiles. Baviloni et al [23] showed the antihyperglycemic activity of stem bark extract of Vatairea macrocarpa in the treatment of diabetic rats. Badole et al [24] found significant antihyperglycemic effects in alloxan-induced diabetic mice treated with Pleurotus pulmonarius and observed that it has potent synergistic antihyperglycemic effects when used in association with glyburide.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated withMalpighia emarginataJuice

Barbalho

Damasceno²,

Spada³

et al. 2011

Experimental Diabetes Research

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Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.

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“…Vatairea macrocarpa Leguminosae Streptozotocin-diabetic rats and type 2 diabetics Improves insulin sensitivity assessed with homeostasis model of insulin resistance but the cellular mechanism is not determined [150,151] 109…”

Section: Tithonia Diversifoliamentioning

confidence: 99%

Antidiabetic plants improving insulin sensitivity

Eddouks¹,

Bidi²,

Bouhali³

et al. 2014

Journal of Pharmacy and Pharmacology

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Background Globally, the prevalence of diabetes mellitus is increasing at an alarming rate. This chronic pathology gravely troubled the human health and quality of life. Both insulin deficiency and insulin resistance are involved in the pathophysiology of diabetes mellitus. Moreover, insulin resistance is being diagnosed nowadays in a growing population of diabetic and obese patients, especially in industrialized societies. There are lots of conventional agents available to control and to treat diabetes, but total recovery from this disorder has not been reported up to this date. Plants provided a potential source of hypoglycemic drugs and are widely used in several traditional systems of medicine to prevent diabetes. A few reviews with less attention paid to mechanisms of action have been published on antidiabetic plants. Objectives The present review focuses on the various plants that have been reported to be effective in improving insulin sensitivity associated with diabetes. Key findings In this work, an updated systematic review of the published literature has been conducted to review the antidiabetic plants improving insulin sensitivity and 111 medicinal plants have been reported to have a beneficial effect on insulin sensitivity using several in-vitro and in-vivo animal models of diabetes. Conclusion The different metabolic and cellular effects of the antidiabetic plants improving insulin sensitivity are reported indicating the important role of medicinal plants as potential alternative or complementary use in controlling insulin resistance associated with diabetes mellitus.

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Mechanism of anti-hyperglycemic action of Vatairea macrocarpa (Leguminosae): Investigation in peripheral tissues

Cited by 11 publications

References 19 publications

Effects of Passiflora edulis on the Metabolic Profile of Diabetic Wistar Rat Offspring

Effects of Passiflora edulis on the Metabolic Profile of Diabetic Wistar Rat Offspring

Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated withMalpighia emarginataJuice

Antidiabetic plants improving insulin sensitivity

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