Mechanism of Acceleration of Wound Healing by Basic Fibroblast Growth Factor in Genetically Diabetic Mice.

Tanaka, Eiko; Ase, Katsuhiko; Ohteki, Toshiaki; Okumura, Makoto; Nogimori, Katsumi

doi:10.1248/bpb.19.1141

Cited by 79 publications

(45 citation statements)

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“…Several studies have shown that bFGF 19,24,26,31) and PDGF 5,8,9) significantly enhanced wound healing. Other studies have shown that TGF-b 6,8,32,33) enhanced wound healing and stimulated migration of neutrophiles and monocytes and that EGF 34) enhanced keratinocyte growth and fibronectin secretion.…”

Section: Discussionmentioning

confidence: 99%

Effect of Zwitterionic Polymers on Wound Healing

Fujishita

Inaba

Tada

et al. 2008

Biological & Pharmaceutical Bulletin

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The effect of a thin film of a zwitterionic random copolymer composed of carboxybetaine [1-carboxy-N,Ndimethyl-N-(2 -methacryloyloxyethyl)methanaminium inner salt] (CMB) and n-butyl methacrylate (BMA), poly(CMB-r-BMA) (CMB, 30 mol%), on the healing of a full-thickness excisional and incisional wound in hairless rats was examined. The poly(CMB-r-BMA) film significantly enhanced wound closure and complete healing of a full-thickness excisional wound compared with the effect of the poly(n-butyl methacrylate) (PBMA) and the poly(ethylene terephthalate) (PET) films. However, the poly(CMB-r-BMA) film did not enhance healing of a fullthickness incisional wound in hairless rats. The amount of proteins adsorbed and that of neutrophiles adhered onto the poly(CMB-r-BMA) film were significantly smaller than those onto the PBMA and PET films. The results suggested that various cells and growth factors in the wound exudate are utilized effectively by covering an excisional wound with the poly(CMB-r-BMA) film, resulting in acceleration of healing. In addition, the poly(CMB-r-BMA) film significantly enhanced healing of a full-thickness excisional wound in hairless rats compared with the effect of Tegaderm ® as wound dressings. The poly(CMB-r-BMA) film has potential as a new wound dressing.

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Section: Discussionmentioning

confidence: 99%

Effect of Zwitterionic Polymers on Wound Healing

Fujishita

Inaba

Tada

et al. 2008

Biological & Pharmaceutical Bulletin

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“…Cells subsequently migrate, proliferate, and form tube-like structures. Numerous researchers have reported that these cellular responses are tightly regulated by signals from various growth factors and cytokines, including vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and interleukin-8 [5][6][7] . Osteopontin, one of the extracellular matrix proteins, is a phosphoric acid protein containing a large quantity of sialic acid.…”

Section: Introductionmentioning

confidence: 99%

Synthetic Osteopontin-derived Peptide SVVYGLR can Induce Neovascularization in Artificial Bone Marrow Scaffold Biomaterials

Hamada

Egusa²,

Kaneda³

et al. 2007

Dent. Mater. J.

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We have previously reported that an osteopontin-derived SVVYGLR peptide exhibited potent angiogenic activity in vitro and in vivo. In the present study, the focus points were on the in vitro effect of SVVYGLR on bone marrow stromal cell proliferation, as well as its in vivo effect on bone tissue formation when grafts made of CO3 Ap-collagen sponge -as a scaffold biomaterial containing the SVVYGLR motif -were implanted. SVVYGLR peptide promoted bone marrow stromal cell proliferation. When a CO3 Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells -as well as prominent angiogenesis -inside the graft could be detected after one week. These results thus suggested that our scaffold biomaterials including the peptide could be useful for bone tissue regeneration.

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“…With recent advances in molecular biology, bFGF has been recognized as a multifunctional growth factor that stimulates angiogenesis, acts as a vasodilatator (12,13), has antiapoptotic effects (14,15), and induces proliferation in various kinds of cells (10,11,16). Actually, the effects of bFGF have been investigated in the field of wound healing (17), bone regeneration (18,19), acute ischemic models (20,21), and myocardial infarction (22,23), both experimentally and clinically. The half-life time of bFGF is relatively short (24), and cross-linked gelatin hydrogel (CGH) has been used to maintain the bioactivity of locally administered bFGF for an extended period (25,26).…”

mentioning

confidence: 99%

Effects of Basic Fibroblast Growth Factor on Experimental Diabetic Neuropathy in Rats

et al. 2006

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Basic fibroblast growth factor (bFGF) stimulates angiogenesis and induces neural cell regeneration. We investigated the effects of bFGF on diabetic neuropathy in streptozotocin-induced diabetic rats. Diabetic rats were treated with human recombinant bFGF as follows: 1) intravenous administration, 2) intramuscular injection into thigh and soleus muscles with cross-linked gelatin hydrogel (CGH), and 3) intramuscular injection with saline. Ten or 30 days later, the motor nerve conduction velocity (MNCV) of the sciatic-tibial and caudal nerves, sensitivity to mechanical stimuli, sciatic nerve blood flow (SNBF), and retinal blood flow (RBF) were measured. Delayed MNCV in the sciatic-tibial and caudal nerves, hypoalgesia, and reduced SNBF in diabetic rats were all ameliorated by intravenous administration of bFGF after 10, but not 30, days. Intramuscular injection of bFGF with CGH also improved sciatic-tibial MNCV, hypoalgesia, and SNBF after 10 and 30 days, but caudal MNCV was not improved. However, intramuscular injection of bFGF with saline had no significant effects. bFGF did not significantly alter RBF in either normal or diabetic rats. These observations suggest that bFGF could have therapeutic value for diabetic neuropathy and that CGH could play important roles as a carrier of bFGF.

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Mechanism of Acceleration of Wound Healing by Basic Fibroblast Growth Factor in Genetically Diabetic Mice.

Cited by 79 publications

References 0 publications

Effect of Zwitterionic Polymers on Wound Healing

Effect of Zwitterionic Polymers on Wound Healing

Synthetic Osteopontin-derived Peptide SVVYGLR can Induce Neovascularization in Artificial Bone Marrow Scaffold Biomaterials

Effects of Basic Fibroblast Growth Factor on Experimental Diabetic Neuropathy in Rats

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