Mechanical testing of electrospun PCL fibers

Croisier, Florence; Duwez, Anne‐Sophie; Jérôme, Christine; Léonard, A.; Werf, Kees O. van der; Dijkstra, Pieter J.; Bennink, Martin L.

doi:10.1016/j.actbio.2011.08.015

Cited by 252 publications

(174 citation statements)

References 29 publications

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“…These values are consistent with previous reports of PCL nanofibrous mesh. 32,33 Morphometry and volume analysis at chamber removal Two animals died owing to infection. No significant inflammation or tissue necrosis was found at the silicone chamber implantation site.…”

Section: Resultsmentioning

confidence: 99%

Polycaprolactone nanofibrous mesh reduces foreign body reaction and induces adipose flap expansion in tissue engineering chamber

Luo¹,

He²,

Chang³

et al. 2016

IJN

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Section: Resultsmentioning

confidence: 99%

Polycaprolactone nanofibrous mesh reduces foreign body reaction and induces adipose flap expansion in tissue engineering chamber

Luo¹,

He²,

Chang³

et al. 2016

IJN

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“…Generally, the mechanical properties of electrospun fibers can be influenced by different parameters including the fiber diameter, topography and porosity, physical and chemical properties of the processed polymer such as polymer molecular weight and its distribution [31,47]. Here, we have mainly focused on the control of fiber diameter over mechanical properties of PCL microfibers scaffolds.…”

Section: Discussionmentioning

confidence: 99%

“…As expected when the fiber diameter decreased, porosity of scaffold increased and which consequently would lead to decrease in Young's modulus. Croisier et al performed the macro-tensile measurements on PCL fiber scaffolds fabricated by solution electrospinning using a higher molecular weight of PCL compared to our study [47].…”

Section: Discussionmentioning

confidence: 99%

Fabrication of poly (ϵ-caprolactone) microfiber scaffolds with varying topography and mechanical properties for stem cell-based tissue engineering applications

Mohtaram

Ahmed

et al. 2013

Journal of Biomaterials Science, Polymer Edition

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Abstract.Highly porous poly (ε-caprolactone) microfiber scaffolds can be fabricated using electrospinning for tissue engineering applications. Melt electrospinning produces such scaffolds by direct deposition of a polymer melt instead of dissolving the polymer in a solvent as performed during solution electrospinning. The objective of this study was to investigate the significant parameters associated with the melt electrospinning process that influence fiber diameter and scaffold morphology, including processing temperature, collection distance, applied voltage and nozzle size. The mechanical properties of these microfiber scaffolds varied with microfiber diameter. Additionally, the porosity of scaffolds was determined by combining experimental data with mathematical modeling. To test the cytocompatability of these fibrous scaffolds, we seeded neural progenitors derived from murine R1 embryonic stem cell lines onto these scaffolds where they could survive, migrate, and differentiate into neurons, demonstrating the potential of these melt electrospun scaffolds for tissue engineering applications.

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“…Fibre characteristics such as fibre diameter and its uniformity, were adjusted by varying several controllable process parameters [22,23] . In this study, six parameters were considered to have major effects on fibre diameter as well as morphology, and they are discussed below:…”

Section: Process Parametersmentioning

confidence: 99%

Influence of electrohydrodynamic jetting parameters on the morphology of PCL scaffolds

Liu¹,

Vijayavenkataraman²,

Wang³

et al. 2017

ijb

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Abstract:One of the important constituents in tissue engineering is scaffold, which provides structural support and suitable microenvironment for the cell attachment, growth and proliferation. To fabricate micro/nano structures for soft tissue repair and three-dimensional (3D) cell culture, the key is to improve fibre-based scaffold fabrication. Electrohydrodynamic (EHD) jetting is capable of producing and orientating submicron fibres for 3D scaffold fabrication. In this work, an EHD-jetting system was developed to explore the relationship between vital processing parameters and fibre characteristics. In this study, polycaprolactone (PCL) solution prepared by dissolving PCL pellets in acetic acid was used to fabricate the scaffolds. The influence of voltage, motorized stage speed, solution feed rate, and solution concentration on fibre characteristics and scaffold pattern were studied. Morphology of the EHD-jetted PCL fibres and scaffolds were analysed using optical microscope images and scanning electron microscope (SEM) images. Multi-layer scaffolds with the varied coiled pattern were fabricated and analysed. Cell attachment and proliferation have to be investigated in the future by further cell culture studies on these multi-layer coiled scaffolds.

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Mechanical testing of electrospun PCL fibers

Cited by 252 publications

References 29 publications

Polycaprolactone nanofibrous mesh reduces foreign body reaction and induces adipose flap expansion in tissue engineering chamber

Polycaprolactone nanofibrous mesh reduces foreign body reaction and induces adipose flap expansion in tissue engineering chamber

Fabrication of poly (ϵ-caprolactone) microfiber scaffolds with varying topography and mechanical properties for stem cell-based tissue engineering applications

Influence of electrohydrodynamic jetting parameters on the morphology of PCL scaffolds

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