Mechanical properties, in vitro corrosion and biocompatibility of newly developed biodegradable Mg-Zr-Sr-Ho alloys for biomedical applications

Ding, Yong; Lin, Jixing; Wen, Cuié; Zhang, Dongmei; Li, Yuncang

doi:10.1038/srep31990

Cited by 39 publications

(28 citation statements)

References 61 publications

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“…These intermetallic phases are both more passive than the α‐matrix, such that the Mg–Sr/Mg–REE couple shows a smaller corrosion current (presumably acting similarly to the mechanism in ref. ), and further are believed to display a smaller potential difference with the Mg‐rich α‐matrix, reducing the driving potential in that couple . The nature of the intermetallic phase may also be important; Mg 2 Ho was most prevalent in the 3 wt% alloy, followed by the 5 wt% alloy (with higher Ho‐content favoring MgHo 3 ), then the 1 wt% alloy, in good agreement with observed corrosion resistances .…”

Section: Rare Earth Application To Magnesium Alloyssupporting

confidence: 73%

Section: Rare Earth Application To Magnesium Alloysmentioning

confidence: 99%

“…To some extent, work from the author's own group has sort to address this, with investigations on the addition of Ho and Dy recently published . Starting with a Mg–Zr–Sr alloy developed in a previous work, Ding et al systematically added increasing amounts of these heavy lanthanides, with 0, 1, 3, and 5 wt% Ho, and 0, 1, 1.63, and 2.08 wt% Dy . In both systems, the REE‐additions reduced the observed degree of corrosion; this decreased consistently with Dy addition up to the investigated limit, while Ho, with its greater investigated range, displayed a minimum corrosion at 3 wt% before subsequently increasing on further addition.…”

Section: Rare Earth Application To Magnesium Alloysmentioning

confidence: 99%

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The Application of the Rare Earths to Magnesium and Titanium Metallurgy in Australia

Biesiekierski

Wen

2019

Advanced Materials

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These elements have huge relevance in the modern world, in applications spanning electronics, biomedicine, structural materials, and more; many rely on their unique electronic properties as the only nonradioactive elements with electrons occupying the f-subshell. [1] However, REEs have long been topics of moderate interest for their application in metallurgy, such as the bulk purification of steels and other alloys, or the improvement of the hightemperature properties of Mg alloys. [3] In recent years, however, progress in materials science has intensified interest in the REE elements. Notably, these are the rise of magnesium (Mg)-based alloys for both biodegradable implant materials and highly weight-sensitive applications in the automotive and aerospace sectors, and the growth of powder-metallurgy (PM) and additive-manufacturing (AM) fabrication methods for titanium (Ti). This change can be seen graphically in Figure 1, with the sharp spike in publications starting shortly after the new millennium. Thus, the importance of REEs, particularly the L-REEs, is highlighted in both the biomedical sector and in high-performance aerospace and automotive roles. Given the biomedical sector represented some 62 000 jobs and $4.9 billion of value to the national GDP in 2016, [5] Australia is well positioned to benefit from advances in biomedical technology; the recent launch of the Australian Space Agency suggests that the aerospace sector may soon grow as well. [6] As such, here, we will attempt to summarize relevant research over the past decade in this field, highlighting work from Australian institutions; the aim of this summary is to help assist in both understanding the current state-of-the-art, and to identify promising areas for future research where Australia is well positioned to leverage existing expertise. Rare Earth Application to Magnesium AlloysMuch of the current research on REE-containing alloys is concerned with Mg alloy systems. Mg-based alloys have long been attractive options in aerospace and automotive applications; at ≈1.7-8 g cm −3 , Mg-based alloys have the lowest density of the common structural metals by a substantial margin, [7] yielding exceptional specific strengths/stiffnesses ideal for weightsensitive applications. Beyond aerospace and automotive sectors, however, the last two decades have seen the sharp rise in interest by the biomedical sector. In this regard, Mg and its alloys are again well suited; Mg shows exceedingly low toxicities coupled with numerous bioactive effects, and can achieve Rare earth elements (REEs) have found application in metallurgical processes for nearly a century due to their unique chemical and physical properties but have gained increased attention in recent decades. Notably, the use of these elements may assist in the development of advanced magnesium and titanium products for applications spanning biomedicine, aerospace, and the automotive industry. To this end, current progress in this area, highlighting work done in Australian research organizations with partic...

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Section: Rare Earth Application To Magnesium Alloyssupporting

confidence: 73%

Section: Rare Earth Application To Magnesium Alloysmentioning

confidence: 99%

Section: Rare Earth Application To Magnesium Alloysmentioning

confidence: 99%

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The Application of the Rare Earths to Magnesium and Titanium Metallurgy in Australia

Biesiekierski

Wen

2019

Advanced Materials

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“…Alloying has successfully addressed some of these concerns. For instance, Mg-Zr-Sr devices exhibit lower degradation rates [31,32], while MgZnCa glasses have reduced levels of hydrogen gas evolution [33]. …”

Section: Introductionmentioning

confidence: 99%

Long-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate

et al. 2017

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Metallic zinc implanted into the abdominal aorta of rats out to 6 months has been demonstrated to degrade while avoiding responses commonly associated with the restenosis of vascular implants. However, major questions remain regarding whether a zinc implant would ultimately passivate through the production of stable corrosion products or via a cell mediated fibrous encapsulation process that prevents the diffusion of critical reactants and products at the metal surface. Here, we have conducted clinically relevant long term in vivo studies in order to characterize late stage zinc implant biocorrosion behavior and products to address these critical questions. We found that zinc wires implanted in the murine artery exhibit steady corrosion without local toxicity for up to at least 20 months post-implantation, despite a steady buildup of passivating corrosion products and intense fibrous encapsulation of the wire. Although fibrous encapsulation was not able to prevent continued implant corrosion, it may be related to the reduced chronic inflammation observed between 10 and 20 months post-implantation. X-ray elemental and infrared spectroscopy analyses confirmed zinc oxide, zinc carbonate, and zinc phosphate as the main components of corrosion products surrounding the Zn implant. These products coincide with stable phases concluded from Pourbaix diagrams of a physiological solution and in vitro electrochemical impedance tests. The results support earlier predictions that zinc stents could become successfully bio-integrated into the arterial environment and safely degrade within a time frame of approximately 1 – 2 years.

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“…Recently, many attempts were made to improve the degradation resistance of Mg-based alloys, mainly by metallurgical and/or surface modifications. The metallurgical modification mainly includes alloying [9,10] and grain refinement by various plastic deformation processes [11,12]. The addition of alloying elements can improve the degradation behaviour of Mg to a greater extent.…”

Section: Introductionmentioning

confidence: 99%

Tailoring biomineralization and biodegradation of Mg–Ca alloy by acetic acid pickling

Rahim

Joseph

Hanas

2020

Mater. Res. Express

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Magnesium and its alloys are suitable candidates for developing biodegradable metallic implants. However, the rapid degradation of these alloys in the physiological environment is a major limitation for such applications. In this work, Mg-Ca alloy was chemically treated with acetic acid and its effects on degradation behaviour were studied using simulated body fluid (SBF). The surface morphology and composition of the acid pickled samples were investigated using a scanning electron microscope (SEM) and infrared spectroscopy (IR). The degradation rate was analysed by conducting potentiodynamic polarization (PDP) and immersion tests. The results show that optimum acetic acid treatment improved the corrosion resistance by acid etching and formation of magnesium acetate layer. The treated samples also exhibited enhanced biomineralization and developed calcium phosphate layer on the surfaces during immersion tests. It is proposed that acetic acid pickling can be used as a reliable technique for surface modification as well as for pre-treatment of magnesium alloys to make them suitable for degradable metallic implant applications.

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Mechanical properties, in vitro corrosion and biocompatibility of newly developed biodegradable Mg-Zr-Sr-Ho alloys for biomedical applications

Cited by 39 publications

References 61 publications

The Application of the Rare Earths to Magnesium and Titanium Metallurgy in Australia

The Application of the Rare Earths to Magnesium and Titanium Metallurgy in Australia

Long-term surveillance of zinc implant in murine artery: Surprisingly steady biocorrosion rate

Tailoring biomineralization and biodegradation of Mg–Ca alloy by acetic acid pickling

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