No abstract

No abstract

The combination of light weight, strength, biodegradability, and biocompatibility of magnesium (Mg) alloys can soon break the paradigm for temporary orthopedic implants. As the fulfillment of Mg-based implants inside the physiological environment depends on the interaction at the tissue–implant interface, surface modification appears to be a more practical approach to control the rapid degradation rate. This article reviews recent progress on surface modification of Mg-based materials to tailor the degradation rate and biocompatibility for orthopedic applications. A critical analysis of the advantages and limitations of the various surface modification techniques employed are also included for easy reference of the readers.

No abstract

Metal‐nanocluster‐mediated cancer diagnosis and therapy has drawn considerable attention in recent years due to the unique optical and photophysical properties of metal clusters. This type of material is highly useful for the diagnosis, treatment, and further follow‐up of disease. However, a single treatment modality is not sufficient for a complete cure. The use of a multi‐therapeutic strategy is among the most promising methods for effective treatment, along with an early‐stage diagnosis. To address the multiple therapeutic modalities in a single nanomaterial, a copper nanocluster was synthesized using glutathione, having inherent singlet oxygen generation and emission at 674 nm. A tumor‐targeting agent (folic acid) and an anticancer drug (doxorubicin) was conjugated to the copper cluster for cancer diagnosis via targeted imaging and further double therapy (photodynamic and chemotherapy) in vitro. 10.5 μg (18.1 nmol) of drug conjugated copper cluster shows 56 % cell death for 30 second laser irradiation in HeLa cells. Effective cancer cell imaging and therapeutic efficacy are demonstrated in vitro.

No abstract

No abstract

No abstract