Mechanical Properties and Biocompatibility of Ti-doped Diamond-like Carbon Films

Zhang, Mengqi; Xie, Tian-yi; Qian, Xuzheng; Zhu, Ye; Liu, Xiaomo

doi:10.1021/acsomega.0c01715

Cited by 40 publications

(25 citation statements)

References 32 publications

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“…Figure d shows the Raman spectra. For the hydrogen-free DLC film, the G peak at ∼1560 cm –1 and D peak at ∼1380 cm –1 represent the breathing mode of sp 2 bonded C atoms and bond stretching of all pairs of sp 2 atoms in chains and rings, respectively. − Figure d shows a weak D peak and strong G peak from C-1#, C-2#, and C-3#, further corroborating successful deposition. Ultrasonic cleaning assay was applied to test the bonding force of DLC coating on Zn.…”

Section: Results and Discussionmentioning

confidence: 61%

Corrosion Behavior and Biocompatibility of Diamond-like Carbon-Coated Zinc: An In Vitro Study

et al. 2021

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Owing to the desirable degradation rate and good biocompatibility, zinc (Zn) and Zn alloys are promising biodegradable implant metals in orthopedic and cardiovascular applications. Surface modification, such as deposition of coatings, is frequently implemented to further enhance their biological properties. In this study, diamond-like carbon (DLC) films are deposited on Zn by magnetron sputtering. The DLC films do not change the surface morphology of Zn but alter the hydrophobic properties with a contact angle of approximately 90°. Electrochemical and in vitro immersion tests reveal that the corrosion resistances of the DLC-coated Zn decrease unexpectedly, which is possibly due to galvanic corrosion between the DLC film and Zn substrate. Furthermore, the uncoated and coated Zn samples show hemolysis ratios less than 1%. The cells cultured in the Zn extract exhibit higher viability than those cultured in the extract of the DLC-coated Zn, suggesting that the DLC films decrease the cytocompatibility of Zn. The lower corrosion resistance has little influence on the hemolysis ratio, suggesting that hemolysis is not an obstacle for the design of Zn-based biomaterials. Our results show that the traditional concept of protection with DLC films may not be applicable universally and decreased corrosion resistance and cytocompatibility are actually observed in DLC-coated Zn.

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Section: Results and Discussionmentioning

confidence: 61%

Corrosion Behavior and Biocompatibility of Diamond-like Carbon-Coated Zinc: An In Vitro Study

et al. 2021

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“…The scratches kept deepening and the friction coefficient (lateral force/normal force) also increased. When the needle tip of the indenter scratched the surface and reached the substrate, the friction curve had an inflection point; this load is the critical load for the failure of the adhesion of the film substrate ( Zhang et al, 2020 ). The critical load is affected by the hardness and elastic modulus of the coating, the substrate, the structure, and thickness of the film, etc.…”

Section: Resultsmentioning

confidence: 99%

Electrophoretic-deposited MXene titanium coatings in regulating bacteria and cell response for peri-implantitis

Huang

2022

Front. Chem.

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Background: Two-dimensional(2D)MXenes have continued to receive increasing interest from researchers due to their graphene-like properties, in addition to their versatile properties for applications in electronic devices, power generation, sensors, drug delivery, and biomedicine. However, their construction and biological properties as titanium coatings to prevent peri-implantitis are still unclear.Materials and methods: In this work, few-layer Ti3C2Tx MXene coatings with different thicknesses at varied depositing voltages (30, 40, and 50 V) were constructed by anodic electrophoretic deposition without adding any electrolytic ions. In vitro cytocompatibility assay was performed on preosteoblasts (MC3T3-E1) cell lines after the characterization of the coating. Meanwhile, the antibacterial activity against bacteria which are closely related to peri-implantitis including Staphylococcus aureus (S. aureus) and its drug-resistant strain MRSA was further investigated.Results: MXene-coated titanium models with different thicknesses were successfully assembled by analyzing the results of characterization. The compounding of Ti3C2Tx could significantly improve the initial adhesion and proliferation of MC3T3-E1 cells. Moreover, the coating can effectively inhibit the adhesion and cell activity of S. aureus and MRSA, and MRSA expressed greater restricting behavior than S. aureus. The ability to promote antibacterial activity is proportional to the content of Ti3C2Tx. Its antioxidant capacity to reduce ROS in the culture environment and bacterial cells was first revealed.Conclusion: In summary, this work shows a new avenue for MXene-based nano-biomaterials under the clinical problem of multiple antibiotic resistance.

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“…It is worth noting that the specific values of hardness and elastic modulus for the PIL were clearly the smallest compared to traditional biomedical implants, PDL [ 60 ] and chitosan [ 61 ] (Figure 4b), whereas the stiffness of the PIL is almost the same as that of human bone. However, the energy‐dissipative properties of traditional biomedical implants with high elastic moduli are prone to degenerate gradually because of their lower energy dissipation, such as Carbon–Ti, [ 62 ] Fe–Mg, [ 63 ] Ti6Al4V, [ 64 ] NiTi, [ 64 ] titanium, Ti–Zr–Nb–Mo, [ 65 ] Ti–Nb–Mg, [ 66 ] Ti–Nb–Zr–Ta, [ 67 ] Ti–24Nb–4Zr, [ 68 ] and Ti–Nb–Zr–Co. [ 68 ] However, owing to the periodontium‐mimetic architecture of the current polymer‐infiltrated amorphous titania‐nanotube‐array, the PIL could simultaneously enhance the osteointegration and energy‐dissipation.…”

Section: Resultsmentioning

confidence: 99%

An Amorphous Peri‐Implant Ligament with Combined Osteointegration and Energy‐Dissipation

et al. 2021

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Progress toward developing metal implants as permanent hard‐tissue substitutes requires both osteointegration to achieve load‐bearing support, and energy‐dissipation to prevent overload‐induced bone resorption. However, in existing implants these two properties can only be achieved separately. Optimized by natural evolution, tooth‐periodontal‐ligaments with fiber‐bundle structures can efficiently orchestrate load‐bearing and energy dissipation, which make tooth–bone complexes survive extremely high occlusion loads (>300 N) for prolonged lifetimes. Here, a bioinspired peri‐implant ligament with simultaneously enhanced osteointegration and energy‐dissipation is presented, which is based on the periodontium‐mimetic architecture of a polymer‐infiltrated, amorphous, titania nanotube array. The artificial ligament not only provides exceptional osteoinductivity owing to its nanotopography and beneficial ingredients, but also produces periodontium‐similar energy dissipation due to the complexity of the force transmission modes and interface sliding. The ligament increases bone–implant contact by more than 18% and simultaneously reduces the effective stress transfer from implant to peri‐implant bone by ≈30% as compared to titanium implants, which as far as is known has not previously been achieved. It is anticipated that the concept of an artificial ligament will open new possibilities for developing high‐performance implanted materials with increased lifespans.

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Mechanical Properties and Biocompatibility of Ti-doped Diamond-like Carbon Films

Cited by 40 publications

References 32 publications

Corrosion Behavior and Biocompatibility of Diamond-like Carbon-Coated Zinc: An In Vitro Study

Corrosion Behavior and Biocompatibility of Diamond-like Carbon-Coated Zinc: An In Vitro Study

Electrophoretic-deposited MXene titanium coatings in regulating bacteria and cell response for peri-implantitis

An Amorphous Peri‐Implant Ligament with Combined Osteointegration and Energy‐Dissipation

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