Mechanical characterization of stomach tissue under uniaxial tensile action

Jia, Zhanrong; Li, W.; Zhou, Zuowan

doi:10.1016/j.jbiomech.2014.12.048

Cited by 45 publications

(27 citation statements)

References 20 publications

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“…Similar morphometric results were obtained by Zhao et al [29] who reported the thickness of the muscularis and the combined mucosa-submucosa as 4mm and 3 mm (3.71 mm in our case), respectively for pigs weighing 100kg. Jia et al [28] also reported similar results for the serosa-muscle (~2.9 mm) layer and combined mucosa-submucosa (~2.9 mm) layer for pigs weighing 140kg. Figure 13 shows the mean and the range of stress-stretch behavior of the porcine stomach wall layers identified with the STiERA system.…”

Section: Resultsmentioning

confidence: 59%

“…This particular probe frequency was chosen in order to attain sufficient intra-layer resolution. Previous studies have shown the porcine stomach muscularis and submucosa-mucosal layers to be 3-4 mm in thickness [28], [56] with the submucosa being a much thinner component of the mucosal-submucosal combined layer. With a 30 MHz probe operating frequency we anticipate to visualize ~70 pixels per mm of gastric tissue, providing substantial layer-specific information.…”

Section: Methodsmentioning

confidence: 99%

“…Three 3 mm thick discs were sliced from each concentration of agar gel master batch to ensure physiologically relevant layer thickness [28], The layers were glued to each other by pipetting 2 ml of warm 8% weight/volume gelatin between the interfaces and then kept in the fridge for 120 seconds in order to set. Three two-layer and three three-layer test samples were prepared for compression tests with STiERA.…”

Section: Methodsmentioning

confidence: 99%

“…This has allowed a variety of ex vivo studies to be performed on stomach [28], [29] and esophagus [30]–[34] where the layers are tested separately. While these tests allow each individual layer to be tested in their no-load states, the degree of tissue damage imparted in surgical separation is unknown and fails to acknowledge the impact of layer-layer bonding on the overall tissue behavior.…”

Section: Introductionmentioning

confidence: 99%

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In Situ Mechanical Characterization of Multilayer Soft Tissue Using Ultrasound Imaging

Dargar

Akyildiz

2017

IEEE Trans. Biomed. Eng.

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In this paper we report the development of a technique to characterize layer-specific nonlinear material properties of soft tissue in situ with the potential for in vivo testing. A Soft Tissue Elastography Robotic Ann (STiERA) system comprising of a robotically manipulated 30 MHz high-resolution ultrasound probe, a custom designed compression head and load cells has been developed to perform compression ultrasound imaging on the target tissue and measure reaction forces. A multi-layer finite element model is iteratively optimized to identify the material coefficients of each layer. Validation has been performed using tissue mimicking agar-based phantoms with a low relative error of ~7% for two--layer phantoms and ~10% error for three layer phantoms when compared to known ground-truth values obtained using a commercial material testing system. The technique has then been used to successfully determine the in situ layer-specific mechanical properties of intact porcine stomach. The mean C10 and C20 for a second order reduced polynomial material model were determined for the muscularis (6.41±0.60, 4.29±1.87 kPa), submucosal (5.21±0.57, 3.68±3.01 kPa) and mucosal layers (0.06±0.02, 0.09±0.24 kPa). Such a system can be utilized to perform in vivo mechanical characterization, which is left as future work.

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Section: Resultsmentioning

confidence: 59%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Situ Mechanical Characterization of Multilayer Soft Tissue Using Ultrasound Imaging

Dargar

Akyildiz

2017

IEEE Trans. Biomed. Eng.

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“…There have been a few papers on the constitutive behavior of the esophagus, small intestine, and large intestine, and around 20 on the mechanical properties of the gastric wall. These revealed that the constitutive properties and thickness of the different layers of the gastric wall differ significantly between different regions of the stomach, corresponding to their respective physiological functions. Most papers on gastric tissue mechanics report results of uniaxial tests only, which are insufficient to characterize the biaxial deformation (in both circumferential and longitudinal direction) observed in vivo, noting the in general significant anisotropy of gastric tissue.…”

Section: Anatomy and Physiology Of The Human Stomachmentioning

confidence: 99%

Mechanics of the stomach: A review of an emerging field of biomechanics

et al. 2019

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Mathematical and computational modeling of the stomach is an emerging field of biomechanics where several complex phenomena, such as gastric electrophysiology, fluid mechanics of the digesta, and solid mechanics of the gastric wall, need to be addressed. Developing a comprehensive multiphysics model of the stomach that allows studying the interactions between these phenomena remains one of the greatest challenges in biomechanics. A coupled multiphysics model of the human stomach would enable detailed in‐silico studies of the digestion of food in the stomach in health and disease. Moreover, it has the potential to open up unprecedented opportunities in numerous fields such as computer‐aided medicine and food design. This review article summarizes our current understanding of the mechanics of the human stomach and delineates the challenges in mathematical and computational modeling which remain to be addressed in this emerging area.

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A finite element approach for gastrointestinal tissue mechanics

Panda

Buist

2019

Numer Methods Biomed Eng

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The biomechanical properties of gastrointestinal (GI) tissue play a significant role in the normal functioning of the organ. GI soft tissues exhibit a highly nonlinear rate‐ and time‐dependent stress‐strain behaviour. In recent years, many constitutive relations have been proposed to characterize these properties. However, a constitutive relation is not sufficient to analyse the biomechanics at the organ level with complex loading and boundary conditions. Hence, for a refined mechanical analysis, a finite element (FE) implementation of the constitutive relation is needed. Here, we propose an FE implementation of a finite nonlinear hyperviscoelastic model suitable for soft biological tissues. The FE model has been validated at first by comparing its results with the analytical solutions of a standard linear solid, and then it has been used to recreate experimental observations performed on tissue strips obtained from different animals. We have also proposed a method, in this work, to construct a residually stressed FE model so that the consequences of residual stresses on GI mechanics can be examined. Our FE formulation was able to capture the nonlinear soft tissue properties and also demonstrated that the addition of residual stresses reduces stress concentrations and the stress gradient in the GI wall.

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Mechanical characterization of stomach tissue under uniaxial tensile action

Cited by 45 publications

References 20 publications

In Situ Mechanical Characterization of Multilayer Soft Tissue Using Ultrasound Imaging

In Situ Mechanical Characterization of Multilayer Soft Tissue Using Ultrasound Imaging

Mechanics of the stomach: A review of an emerging field of biomechanics

A finite element approach for gastrointestinal tissue mechanics

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