Mechanical characterization of injection-molded macro porous bioceramic bone scaffolds

Vivanco, Juan; Aiyangar, Ameet; Araneda, Aldo; Ploeg, Heidi‐Lynn

doi:10.1016/j.jmbbm.2012.02.003

Cited by 45 publications

(21 citation statements)

References 86 publications

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“…In spite of that, most of existing studies have focused on the evaluation of the compressive behavior of scaffolds [19–24], without much information regarding their flexural performance. Indeed, there are only a few studies on this topic, dealing mostly with nearly dense ceramic samples [25–28] or randomly porous structures [14,15,29,30], but none in the case of the promising polymer/ceramic robocast structures.…”

Section: Introductionmentioning

confidence: 99%

Effect of Polymer Infiltration on the Flexural Behavior of β-Tricalcium Phosphate Robocast Scaffolds

et al. 2014

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The influence of polymer infiltration on the flexural strength and toughness of β-tricalcium phosphate (β-TCP) scaffolds fabricated by robocasting (direct-write assembly) is analyzed. Porous structures consisting of a tetragonal three-dimensional lattice of interpenetrating rods were impregnated with biodegradable polymers (poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL)) by immersion of the structure in a polymer melt. Infiltration increased the flexural strength of these model scaffolds by a factor of 5 (PCL) or 22 (PLA), an enhancement considerably greater than that reported for compression strength of analogue materials. The greater strength improvement in bending was attributed to a more effective transfer of stress to the polymer under this solicitation since the degree of strengthening associated to the sealing of precursor flaws in the ceramic rod surfaces should remain unaltered. Impregnation with either polymer also improved further than in compression the fracture energy of the scaffolds (by more than two orders of magnitude). This increase is associated to the extraordinary strengthening provided by impregnation and to a crack bridging toughening mechanism produced by polymer fibrils.

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Section: Introductionmentioning

confidence: 99%

Effect of Polymer Infiltration on the Flexural Behavior of β-Tricalcium Phosphate Robocast Scaffolds

et al. 2014

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“…In addition, it is important to know that the scaffold mechanical properties will decrease with the scaffold degradation. Thus, if the scaffolds have sufficient mechanical properties at the time of implantation, the change of their mechanical properties during the degradation could be expected and affected on the function within the tissue defect [107,108].…”

Section: Challengesmentioning

confidence: 99%

Bioceramic Scaffolds

Amin¹,

Ewais²

2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Millions of peoples in the world suffer from their bone damage tissues by disease or trauma. Every day, thousands of surgical procedures are performed to replace or repair these tissues. The availability of these tissues is a big problem, and their costs are expensive. The repair of these defects has become a major clinical and socioeconomic need with the increase of aging population and social development. The emerge of tissue engineering (TE) is considered as a glimmer of hope to contribute in solving this problem. It aims at the regeneration of damaged tissues with restoring and maintaining the function of human bone tissues using the combination of cell biology, materials science, and engineering principles. In this chapter, the current state of the tissue engineering in particular bioceramic scaffolds was discussed. Concept of tissue engineering was explored. Bioceramic scaffold materials, their processing techniques, challenges taken into consideration the design of the scaffolds, and their in-vitro and in-vivo studies were highlighted. The scaffolds with extra-functionalities such as drug release ability and clinical applications were mentioned.

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“…Porosities in the range of 60-95% (Oh et al, 2007) are generally suitable, but also lower porosities of 50% have been used (Vivanco et al, 2012). Ideally, the scaffolds have a high porosity containing a high ratio of interconnected pores.…”

Section: Regeneration Of Critical Size Defects By Tissue Engineeringmentioning

confidence: 99%

“…Fused deposition modelling and the similar precision extruding deposition generate three-dimensional (3D) porous structures by depositing lines of melted polymer on a motor-driven x-y-z-table (Weigel et al, 2006). Diameters in the range of 200-500 mm can be performed, resulting in a high material fraction and thus low porosities between 50% and 75% (Vivanco et al, 2012;Weigel et al, 2006). Using CAD, one can produce scaffolds with pore sizes of 200-500 mm with a 100% ratio of interconnected pores.…”

Section: Scaffolds For Bone Tissue Engineeringmentioning

confidence: 99%

Embroidery technology for hard-tissue scaffolds

Breier

2015

Biomedical Textiles for Orthopaedic and Surgical Applications

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Mechanical characterization of injection-molded macro porous bioceramic bone scaffolds

Cited by 45 publications

References 86 publications

Effect of Polymer Infiltration on the Flexural Behavior of β-Tricalcium Phosphate Robocast Scaffolds

Effect of Polymer Infiltration on the Flexural Behavior of β-Tricalcium Phosphate Robocast Scaffolds

Bioceramic Scaffolds

Embroidery technology for hard-tissue scaffolds

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