Mechanical biocompatibility of highly deformable biomedical materials

Guidelines for standardization of bioprinting: a systematic study of process parameters and their effect on bioprinted structures

“…Unauthenticated Download Date | 5/9/18 10:01 PM will be in the intended implantation site. Furthermore, the importance of a correct match of the deformation behavior of the implant material and the underlying tissue has recently been shown [8]. These properties are a function of the material itself, as well as bioprinting process parameters ( Figure 1B).…”

Mechanical properties and permeability of porous chitosan–poly(p-dioxanone)/silk fibroin conduits used for peripheral nerve repair

“…In the case of long-gap nerve repair, necessitated conduits must be able to withstand perigraft tissue compression arisen from muscle contraction, joint movement and body weight for a required period of time (Mazza and Ehret, 2015). Thus, suitable conduits need to resist degradation to some extent while maintaining certain compressive strength and a Concentration of lysozyme in degradation media was 4 mg/ml; samples were measured at 40% strain.…”

Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering

“…These studies characterized hydrogels in terms of stiffness and strength, while no information was provided on their kinematic response or cyclic evolution of mechanical properties. These aspects have been proposed as important factors determining mechanical biocompatibility [19] and are expected to influence the manipulation of the bio-engineered skin construct on behalf of surgeons [14].…”

“…Final achievable collagen concentrations, expressed in weight per volume, can reach 1.5% with the cell-mediated contraction [10] and can range from 5% to 20-25% with the plastic compression [16,17]. Collagen amount and crosslink concentration determine the mechanisms of deformation and the stiffness of the resulting network [10,18], and the paradigm of mechanical biocompatibility [19] indicates that similarity of the deformation behavior of an implant and that of the underlying or surrounding native tissue is crucial for a successful integration. In fact, it has been shown that an increasing density of the collagen matrix correlates with enhanced fibroblast motility and proliferation [20,21], until an upper limit is reached [10,22].…”