Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering

Pensalfini, Marco; Ehret, Alexander E.; Stüdeli, Silvia; Marino, Daniela; Kaech, Andres; Ernst, Rolf; Mazza, Edoardo

doi:10.1016/j.jmbbm.2016.12.004

Cited by 32 publications

(14 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Skin SWE is an objective, noninvasive tool that would be convenient to observe the process of skin aging and diseases with solidity changing, such as photo-aging, [18] scar, [19] systemic sclerosis, [20] lymphoma, and the other skin cancers. [12] In this study, we obtained high reproducibility in tested areas when minimize the influence of muscle and bone.…”

Section: Resultsmentioning

confidence: 99%

Reproducibility analysis on shear wave elastography (SWE)-based quantitative assessment for skin elasticity

Sun¹,

Liang³

et al. 2017

Medicine

View full text Add to dashboard Cite

Shear Wave Elastography (SWE) is an objective and non-invasive method widely used to quantify the tissue solidity. However, there are concerns about the accuracy of the skin SWE results due to the low signal-to-noise ratio (SNR) caused by subcutaneous fat, muscle and bone. This article analyzed the reproducibility of the result for skin SWE and therefore evaluated the availability of SME for skin elasticity involved diseases. Thirty volunteers (mean age: 37 ± 12 years) were selected. SWE were taken on the skin of abdomen and the middle tibia in order to assess the impact of fat, muscle and bone on SWE results. Skin in the area of anterior and lateral tibia marked with seven parallel lines, and each line indicated an identical thickness of the subcutaneous fat from 1–7 mm. Intra-class correlation coefficients (ICC) were used to evaluate the intra-observer and inter-observer reproducibility. The solidity of abdominal skin showed soft and small individual differences (12.4 ± 2.7 kPa), whereas high shear moduli (25–48 kPa) were observed in the skin above tibia and tibialis anterior muscle. When the subcutaneous fat was thicker than 3 mm (≥3), we obtained excellent intra-observer reproducibility (ICC range 0.78–0.98) and inter-observer reproducibility (ICC range 0.75–0.98). The thickness of subcutaneous fat could affect the reproducibility of skin SWE. The further study on skin SWE standardization should be taken.

show abstract

Section: Resultsmentioning

confidence: 99%

Reproducibility analysis on shear wave elastography (SWE)-based quantitative assessment for skin elasticity

Sun¹,

Liang³

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

“…Plastic compression correlated to a dense material, with thickness and excess of water. The observed characteristics are relevant in terms of biocompatibility to obtain a skin-like behavior to maintain the surface of the wound wet, promote epithelialization and rehydrate dry wounds (Correa et al, 2005;Gainza et al, 2015;Pensalfini et al, 2017).…”

Section: In Vivo Healing Evaluationmentioning

confidence: 99%

Efficacy of application of Equisetum pyramidale Goldm. hydrogel for tissue restoration of induced skin lesions in Wistar rats

et al. 2020

View full text Add to dashboard Cite

Abstract Medicinal plants, such as E. pyramidale, are alternatives against infections and assist in the healing process of wounds. We evaluated the effects of Hydrogel of E. pyramidale on the healing of cutaneous wounds in animal models by morphological, morphometric and histological analyses, and elucidated major components. The ethanolic extract of E. pyramidale shoots was submitted to phytochemical analysis. For cicatrizing activity assay, Wistar rats were used, and the groups evaluated were hydrogel containing ethanolic extract of E. pyramidale at 2% compared to control groups. The treatment periods were 3, 7 and 21 days, and macroscopic and microscopic analyses were performed. Data were submitted to Analysis of Variance (p <0.05). Phytochemistry and quantification evidenced that flavonoids are main constituents and that they were evidenced by thin layer chromatography (TLC), high efficiency (HPLC) and infrared (IR) methods. In TLC, using flavonoid patterns, we observed pinocembrin. The hydrogel containing ethanolic extract of E. pyramidale at 2% was effective in wound regression. E. pyramidale can be used for the treatment of second intention wounds, and the effective healing may be due to a high flavonoid content.

show abstract

“…Hydrogels are three dimensional, porous, hydrophilic, physical and chemical crosslinking networks that swell thousands time of their dry weight in the vicinity of water [1]. These materials can respond to specific changes in their environment such as temperature, pH, magnetic field, and the electric field which determines their application in the fields of medicine, tissue engineering [2], wound dressing [3], biosensors [4], pharmaceutical [5], agriculture [6]and adsorption [7]. Hydrogels have found a special place in the field of wastewater treatments.…”

Section: Implementation Of Carboxymethyl Cellulose/acrylic Acid/ Titamentioning

confidence: 99%

Implementation of Carboxymethyl cellulose/Acrylic acid/ Titanium dioxide Nanocomposite Hydrogel in Remediation of Cd(II), Zn(II) and Pb(II) for Water treatment application

Hendy¹,

Khozamy²,

Mahmoud

et al. 2019

Egypt. J. Chem.

View full text Add to dashboard Cite

I N THIS study Acrylic acid/ Carboxymethylcellulose/Titanium dioxide (AAc/CMC-TiO 2) hydrogel nanocomposite was synthesized by free-radical crosslinking copolymerization via gamma irradiation. It was characterized using FT-IR and swelling properties. The swelling percentage increases with increasing time until reaches a certain limiting value after 6h. The synthesized nanocomposite was used as an adsorbent for remediation of Cd(II), Zn(II) and Pb(II) from aqueous solutions by the static adsorption technique. It was found that the optimum pH for the adsorption is 5 and the sorption process is carried out at fast operating time, 30-40 min, for all investigated metal ions. It was also found that the metal ions sorption capacity decreases with increasing the dosage of AAc/CMC-TiO 2 from 5 to 150 mg. A progressive increase in the metal ions sorption capacity was obtained with increasing the initial metal ion concentration from 0.01 to 0.05 mol L-1 and the saturation of the sorbent active sites was done at initial metal ions concentration at 0.1 mol L-1. No significant interference on the removal of Pb (II) in the presence of NaCl, Na-acetate, KCl, KNO 3 and NH 4 Cl ions while a slight decrease in removal of Cd (II)and Zn(II) was done. The pseudo-second order kinetic model and Freundlich adsorption model describe well the kinetic and isotherm, respectively, of the adsorption process of the investigated ions.

show abstract

Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering

Cited by 32 publications

References 47 publications

Reproducibility analysis on shear wave elastography (SWE)-based quantitative assessment for skin elasticity

Reproducibility analysis on shear wave elastography (SWE)-based quantitative assessment for skin elasticity

Efficacy of application of Equisetum pyramidale Goldm. hydrogel for tissue restoration of induced skin lesions in Wistar rats

Implementation of Carboxymethyl cellulose/Acrylic acid/ Titanium dioxide Nanocomposite Hydrogel in Remediation of Cd(II), Zn(II) and Pb(II) for Water treatment application

Contact Info

Product

Resources

About