Mechanical and microscopical characterisation of bilayer hydrogels strengthened by TiO2 nanoparticles as a cartilage replacement candidate

Mostakhdemin, Mohammad; Nand, Ashveen V.; Arjmandi, Mohammadreza; Ramezani, Maziar

doi:10.1016/j.mtcomm.2020.101279

Cited by 11 publications

(6 citation statements)

References 15 publications

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“…While most individuals from the exploiter network can get a handle on the significance of nanotechnology and can expertly dispatch and deal with a reasonable item on the market, they are restricted in their applied comprehension of this logical order and the unpredictable internal activities behind the item’s usefulness [ 94 ]. Those engaged in scientific research perceive that nanomedicine is a development of nanotechnology, yet their business mastery required to advance an item in business is very low [ 99 ]. Participation is hence required between the two groups in a quest to lead nanomedicine-based innovations to an effective showcase position.…”

Section: Nanomaterials For Biomedical Applicationsmentioning

confidence: 99%

“…Tissue malfunctioning has become a noteworthy medical issue in the United States and most other geographical areas around the world. It was reported that only the United States has around 89000 patients who need tissue or organ transplantation [ 99 ]. Recently, a brilliant interdisciplinary field was able to solve the issue of tissue and organ replacement, which is called nanomedicine.…”

Section: Nanomaterials For Biomedical Applicationsmentioning

confidence: 99%

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Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

et al. 2021

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Designing of nanomaterials has now become a top-priority research goal with a view to developing specific applications in the biomedical fields. In fact, the recent trends in the literature show that there is a lack of in-depth reviews that specifically highlight the current knowledge based on the design and production of nanomaterials. Considerations of size, shape, surface charge and microstructures are important factors in this regard as they affect the performance of nanoparticles (NPs). These parameters are also found to be dependent on their synthesis methods. The characterisation techniques that have been used for the investigation of these nanomaterials are relatively different in their concepts, sample preparation methods and obtained results. Consequently, this review article aims to carry out an in-depth discussion on the recent trends on nanomaterials for biomedical engineering, with a particular emphasis on the choices of the nanomaterials, preparation methods/instruments and characterisations techniques used for designing of nanomaterials. Key applications of these nanomaterials, such as tissue regeneration, medication delivery and wound healing, are also discussed briefly. Covering this knowledge gap will result in a better understanding of the role of nanomaterial design and subsequent larger-scale applications in terms of both its potential and difficulties.

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Section: Nanomaterials For Biomedical Applicationsmentioning

confidence: 99%

Section: Nanomaterials For Biomedical Applicationsmentioning

confidence: 99%

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

et al. 2021

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“…Seddiki et al [ 133 ] reported that TiO 2 NPs and a high dosage of crosslinking agents (15%) are vital factors affecting swelling ratio. Furthermore, it has been reported that carboxyl groups formed complexes with TiO 2 NPs via different methods to crosslink polymer chains [ 192 ].…”

Section: Strengthening Of Hydrogels With Nanoparticlesmentioning

confidence: 99%

Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches—A Review

2021

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The design and manufacture of artificial tissue for knee joints have been highlighted recently among researchers which necessitates an apt approach for its assessment. Even though most re-searches have focused on specific mechanical or tribological tests, other aspects have remained underexplored. In this review, elemental keys for design and testing artificial cartilage are dis-cussed and advanced methods addressed. Articular cartilage structure, its compositions in load-bearing and tribological properties of hydrogels, mechanical properties, test approaches and wear mechanisms are discussed. Bilayer hydrogels as a niche in tissue artificialization are presented, and recent gaps are assessed.

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“…12 Polymeric hydrogel is an ideal candidate for replacing damaged articular cartilage. 13,14 Owing to its good biocompatibility and hydrophilicity, the hydrogel has been extensively investigated and widely applied in the biomedical field. 15,16 Similar to cartilage, hydrogels possess a three-dimensional network structure and exhibit solidliquid two-phase properties.…”

Section: Introductionmentioning

confidence: 99%

“…Polymeric hydrogel is an ideal candidate for replacing damaged articular cartilage 13,14 . Owing to its good biocompatibility and hydrophilicity, the hydrogel has been extensively investigated and widely applied in the biomedical field 15,16 .…”

Section: Introductionmentioning

confidence: 99%

Construction and tribological properties of poly acrylic acid‐poly(3‐(methacryloylamino)propyl) dimethyl(3‐sulfopropyl)ammonium hydroxide hydrogel coatings embedded with SiO₂ nanoparticles on Ti6Al4V substrate

Deng,

Nie,

et al. 2024

J of Applied Polymer Sci

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The development of highly effective bio‐lubricant coatings for arthritis treatment is extremely demanded. Herein, inspired by the efficient lubrication of articular cartilage, acrylic acid (AA) with (3‐(methacryloylamino) propyl) dimethyl (3‐sulfopropyl) ammonium hydroxide (MPDSAH) hydrogel coatings containing nanoparticles on Ti6Al4V substrate were designed and fabricated via UV grafting technology. SiO2 and SiO2 grafted with PAA polymer brushes (SiO2‐g‐PAA) were separately doped into the PAA‐PMPDSAH hydrogel. The PAA‐PMPDSAH/SiO2‐g‐PAA exhibits good tensile and compressive properties compared with PAA‐PMPDSAH/SiO2 hydrogel, with an enhancement of 183.4% in tensile modulus and 60.8% in compressive modulus. The PAA‐PMPDSAH/SiO2‐g‐PAA hydrogel coatings exhibit a low wear volume, 2.9 ± 0.16 × 106 μm3, representing a decline of 32.1% and 61.3% compared with the PAA‐PMPDSAH and PAA‐PMPDSAH/SiO2 hydrogel coatings, respectively. The antiwear performance has obviously improved. The hydrophilic PAA polymer brushes prevent the agglomeration of nanoparticles and promote homogeneously dispersion within the hydrogel. The three‐dimensional crosslinked network structure of hydrogel effectively protects the structural integrity of the polymer brushes, thereby facilitating enduring lubrication properties. This work provides a strategy for promising artificial joint lubrication in biomedical fields.

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Mechanical and microscopical characterisation of bilayer hydrogels strengthened by TiO2 nanoparticles as a cartilage replacement candidate

Cited by 11 publications

References 15 publications

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches—A Review

Construction and tribological properties of poly acrylic acid‐poly(3‐(methacryloylamino)propyl) dimethyl(3‐sulfopropyl)ammonium hydroxide hydrogel coatings embedded with SiO₂ nanoparticles on Ti6Al4V substrate

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Mechanical and microscopical characterisation of bilayer hydrogels strengthened by TiO2 nanoparticles as a cartilage replacement candidate

Cited by 11 publications

References 15 publications

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches—A Review

Construction and tribological properties of poly acrylic acid‐poly(3‐(methacryloylamino)propyl) dimethyl(3‐sulfopropyl)ammonium hydroxide hydrogel coatings embedded with SiO2 nanoparticles on Ti6Al4V substrate

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Product

Resources

About

Construction and tribological properties of poly acrylic acid‐poly(3‐(methacryloylamino)propyl) dimethyl(3‐sulfopropyl)ammonium hydroxide hydrogel coatings embedded with SiO₂ nanoparticles on Ti6Al4V substrate