Meat intake, 'mate' drinking and renal cell cancer in Uruguay: a case-control study

Abstract

SummaryIn the period January 1988-December 1995. a case-control study of diet and renal cell carcinoma (RCC) risk involving 121 cases and 243 hospitalized controls was carried out in Montevideo, Uruguay. After adjusting for major covariates, red meat intake was associated with a 3.4 increase in risk for the highest category of intake, with a significant dose-response pattem. Also, barbecued meat, protein and heterocyclic amine intakes were associated with significant increases in risk of RCC. The consumption of the beverage known as 'mate' (a local tea derived from the herb Ilex paraguariensis) was associated with an increased risk of 3.0 for heavy drinkers. by tx-o trained social wvorkers using a standard routine questionnaire. designed to obtain information on risk factors for all cancers and non-neoplastic conditions. The database so created. from which the study subjects were obtained. has also been used for a study of luncg cancer (De Stefani et al. 1996). In this particular instance. all patients w-ith RCC admitted to the Instituto Nacional de Oncologia in the time period 1988-95 and successfully interviewed were included in the case series. The response rate for cases was high (92.7%7). All cases were histologically verified as having RCC. Most had RCC of the clear cell variant (85%7c). The remaining, 15%7 had RCC of the eosinophilic cell variant.In the same period. 5295 patients with a variety of other disorders. both neoplastic and non-neoplastic. were admitted to the same institution. The oxerall response rate for these patients was 93.0%c. From this pool of patients. potential controls were randomly selected excluding the following conditions: (1) malignancies. (2) smoking-related conditions. (3) conditions related to mate' consumption (see hst above) and (4) digestive diseases or disorders associated Awith a long-term modification of diet. Cases were frequency matched with controls on age. sex and residence.

A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

“…Ecological studies have shown positive associations between per-capita consumption of fat and protein intake with kidney cancer mortality rates. 2,3 Case-control studies have also found positive associations between risk of renal cell carcinoma and a high intake of energy, [4][5][6][7][8][9] protein and fat, particularly from animal foods, 4,6,7,10 and negative associations with polyunsaturated fat intake. 11,12 However, the evidence from prospective studies is sparse and the World Cancer Research Fund concluded that there is no consistent support for any foods or nutrients with renal cell carcinoma risk.…”

No Association Between Tea Consumption and Risk of Renal Cell Carcinoma: A Meta-analysis of Epidemiological Studies

“…The present study included twelve epidemiological studies (ten case-control (McLaughlin et al, 1984;Goodman et al, 1986;Talamini et al, 1990;Kreiger et al, 1993;Mellemgaard et al, 1994;De Stefani et al, 1998;Bianchi et al, 2000;Hu et al, 2009;Montella et al, 2009;Wang et al, 2012) and two cohort studies (Lee Table 1. Of the ten case-control studies, five were conducted in the USA/Canada (McLaughlin et al, 1984;Goodman et al, 1986;Kreiger et al, 1993;Bianchi et al, 2000;Hu et al, 2009), and the remaining five were conducted in Denmark (Mellemgaard et al, 1994), Italy (Montella et al, 2009), Uruguay (De Stefani et al, 1998), and China (Wang et al, 2012).…”

“…Of the ten case-control studies, five were conducted in the USA/Canada (McLaughlin et al, 1984;Goodman et al, 1986;Kreiger et al, 1993;Bianchi et al, 2000;Hu et al, 2009), and the remaining five were conducted in Denmark (Mellemgaard et al, 1994), Italy (Montella et al, 2009), Uruguay (De Stefani et al, 1998), and China (Wang et al, 2012). Of the two cohort studies, one was conducted in UK (Allen et al, 2011), and the other one was conducted in the USA (Lee et al, 2007).…”

“…Figure 1 is a flow diagram of the procedure used to identify the relevant studies. A total of 12 articles were finally included in the meta-analysis (McLaughlin et al, 1984;Goodman et al, 1986;Talamini et al, 1990;Kreiger et al, 1993;Mellemgaard et al, 1994;De Stefani et al, 1998;Bianchi et al, 2000;Lee et al, 2007;Hu et al, 2009;Montella et al, 2009;Allen et al, 2011;Wang et al, 2012).…”

“…One case-control study reported that a higher consumption of tea significantly increased the risk of renal cell carcinoma (De Stefani et al, 1998), whereas seven case-control studies showed a non-significant positive association (McLaughlin et al, 1984;Goodman et al, 1986;Talamini et al, 1990;Kreiger et al, 1993;Mellemgaard et al, 1994;Bianchi et al, 2000;Hu et al, 2009), and two case-control studies showed a nonsignificant negative association between tea consumption and renal cell carcinoma (Montella et al, 2009;Wang et al, 2012). In contrast, one prospective cohort study reported that higher tea consumption could decrease the risk of renal cell carcinoma (Lee et al, 2007), while the other cohrot study showed that there was no significant association (Allen et al, 2011).…”